Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments.

Methods in molecular medicine

Volumn 90, Issue , 2004, Pages 279-301

  Schepelmann, Silke ^a   Spooner, Robert ^a   Friedlos, Frank ^a   Marais, Richard ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 ((2 CHLOROETHYL)(2 MESYLOXYETHYL)AMINO)BENZOYLGLUTAMIC ACID; 4-((2-CHLOROETHYL)(2-MESYLOXYETHYL)AMINO)BENZOYLGLUTAMIC ACID; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 5-(1-AZIRIDINYL)-2,4-DINITROBENZAMIDE; ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; CHLORMETHINE DERIVATIVE; GAMMA GLUTAMYL HYDROLASE; GLUTAMIC ACID DERIVATIVE; NITROREDUCTASE; PRODRUG;

ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL FRACTIONATION; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; OVARY TUMOR; SUICIDE TRANSGENE;

ANTINEOPLASTIC AGENTS; AZIRIDINES; BYSTANDER EFFECT; CELL SURVIVAL; FEMALE; GAMMA-GLUTAMYL HYDROLASE; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GLUTAMATES; HUMANS; NITROGEN MUSTARD COMPOUNDS; NITROREDUCTASES; OVARIAN NEOPLASMS; PRODRUGS; SUBCELLULAR FRACTIONS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 1542467512     PISSN: 15431894     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)