Targeting hepatocytes with liposomal interferon-alpha: Effect on metallothionein gene induction

Research Communications in Molecular Pathology and Pharmacology

Volumn 112, Issue 1-4, 2002, Pages 50-58

  Polikandritou Lambros, M ^a   Ali Abbas, S ^b   Dunn, S T ^b   Raja, T ^c   Pento, T ^b  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SOUTHEAST   (United States)

Author keywords

Chang liver cells; Dimyristoylphosphatidyl glycerol (DMPG); Dimyristoylphosphatidylcholine (DMPC); Dioleyl phosphatidyl ethanolamine (DOPE); Encapsulation; Hepatitis B; Hybridization; Interferon ; Liposomes; Metallothionein gene (MT IIA); Northern blot

Indexed keywords

ALPHA INTERFERON; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; MESSENGER RNA; METALLOTHIONEIN;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; GENE EXPRESSION; GENE INDUCTION; HEPATITIS B; HUMAN; HUMAN CELL; LIVER CELL; METALLOTHIONEIN GENE; NORTHERN BLOTTING; PRIORITY JOURNAL; RNA EXTRACTION; RNA ISOLATION;

ANIMALS; BLOTTING, NORTHERN; CELL LINE; DNA PROBES; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; HEPATOCYTES; INTERFERON-ALPHA; LIPOSOMES; METALLOTHIONEIN; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 1542426559     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Chomczynski, P., Sacchi, n. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.
2. Finter, N.B., Chapman, S., Dowd, P., Johnston, J.M., Manna, V, Sarantis, N., Sheron, N., Scott, G., Phua S., and Tatum, P.B. (1991) The use of interferon-α in virus infections. Drugs. 2, 749-765.
3. Friedman, L.R., Manly, S.P., McMahon, M., Kerr, I.M., Stark, G.R. (1984). Transcriptional and post-transcriptional regulation of interferon-induced gene expression in human cells. Cell, 38, 745-755.
4. Friedman, L.R., Stark, G.R. (1985). Alpha-interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature, 314, 637-639.
5. Jonhson, P.C., Wheat, L.J., Cloud, G.A., Golman, M., Lancaster, D., Bamberger, D.M., Powderly, W.G., Hafner R., Kauffman, C.A. and Dismukes, W.E. (2002). Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS. Ann Intern Med. 137, 105-9.
6. Kaewprasert, S., Okada, M., and Aoyama, Y. (2002). Metallothionein mRNA levels are influenced by dietary cyclodextrins in rats. J. Nutr. Biochem. 13, 219-225.
7. Lazo, J.S., Pitt, B.R.(1995) Metallothioneins and cell death by anticancer drugs. Ann. Rev. Pharmacol. Toxicol. 35, 635-653.
8. Leyshon-Sorland K., Morkrid, L., and Rugstad, H.E. (1993). Metallothionein: a protein conferring resistance in vitro to tumor necrosis factor. Cancer Res. 53, 4874-4880.
9. Liu, J., Liu, Y.P., Sendelback, L.E., and Claassen, C.D. (1991). Endotoxin induction of hepatic metallothionein is mediated through cytokines. Toxicol. Appl. Pharm. 109, 235-240.
10. McAlister, V.C., Al-Jazerim A., and Wright J.R. Jr. (2002) Liposomal encapsulation significantly enhances the immunosuppressive effect of tacrolimus in a discordant islet xenotransplant model. Transplantation. 73, 710-713.
11. McKenna, I.M., Bare, R.M., Waalkes, M.P. (1996) Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium. Toxicol. 107, 121-130.
12. Nishimura, N., Miyabara, Y., Suzuki, J.S., Sato, M., Aoki, Y., Satoh, M., Yonemoto, J., Tohyama, C (2001) Induction of metallothionein in the livers of female Sprague-Dawley rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Life Sciences 69, 1291-1303.
13. Rizkalla, K.S., and Cherian, M.G. (1997). Metallothionein: a potential marker for differentiating benign and neoplastic gastrointestial lymphoid infiltrates. Pathology 29, 141-146.
14. Taylor, J. L. and Grossberg S.E. (1990): Recent progress in interferon research: molecular mechanisms of regulation, action, and virus circumvention. Virus Res. 15, 1-26.