Methodologic pitfalls in measurement of 5-hydroxytriptamine uptake transporters in human platelets by [3H]-paroxetine binding assay

Archives of Medical Research

Volumn 34, Issue 5, 2003, Pages 422-427

  Jurado, Noé ^a   Torner, Carlos ^b   Heinze, Gerhard ^a   López, Guadalupe ^a   Mendoza Sotelo, José ^a   Lazo Langner, Alejandro ^c   Moreno, Julia ^a,d  

^a INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

^b DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

Author keywords

3H Paroxetine; Antidepressive drugs; Binding; Platelets; Serotonin transport complex

Indexed keywords

PAROXETINE; PROTEIN; SEROTONIN TRANSPORTER; CARRIER PROTEIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRITIUM;

ADULT; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; HEALTH STATUS; HUMAN; HUMAN CELL; NORMAL HUMAN; SEROTONIN UPTAKE; TEMPERATURE; THROMBOCYTE MEMBRANE; TIME; VALIDATION PROCESS; CHEMISTRY; METABOLISM; METHODOLOGY; MIDDLE AGED; PROTEIN BINDING; RADIOASSAY; REPRODUCIBILITY; THROMBOCYTE;

ADULT; BLOOD PLATELETS; CARRIER PROTEINS; HUMANS; MIDDLE AGED; PAROXETINE; PROTEIN BINDING; RADIOLIGAND ASSAY; REPRODUCIBILITY OF RESULTS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TEMPERATURE; TRITIUM;

EID: 1542394881     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2003.03.001     Document Type: Article

References (31)

1. Malmgren R.S., Kjellman B.F., Aberg-Wisted A. Platelet serotonergic functions and light therapy in seasonal affective disorders. Psychiatr Res. 78:1998;163-172.
2. Lesch K.P., Wolozin B.L., Murphy D.L., Riederer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem. 60:1993;2319-2322.
3. Da Prada M., Kettler R., Burkard W.P., Lorez H.P., Hafely W. Some basic aspects of reversible inhibitors of monoamine oxidase-A. Acta Psychiatr Scand Suppl. 36:1990;7-12.
4. Cook E.H. Jr., Arora R.C., Anderson G.M., Berry-Kravis E.M., Yan S.-Y., Yeon H.C., Sklena P.J., Charak Bennett D.A., Leventhal L. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sci. 52:1993;2005-2015.
5. Mannion L., Nugent D., Leonard B. Platelet studies in panic disorder: a review. Ir J Psychiatr Med. 14:(4):1997;139-143.
6. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Lish J.D., Csernansky J.G. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry. 53:1996;531-536.
7. Briley M.S., Langer S.L., Raiman R., Sechter D., Zarifian E. Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science. 209:1980;303-305.
8. Raisman R., Sechter D., Briley M.S., Zarifian E., Langer S.Z. High-affinity 3H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers. Psychopharmacology (Berl). 75:(4):1981;368-371.
9. 3H-imipramine bindings to platelets of depressed patients free of previous medication with 5HT uptake inhibitors. Psychopharmacology (Berl). 89:1986;456-461.
10. Maj M., Mastronardi P., Palomba U., Romano M., Ventra C., Kemali D. Platelet 3H-imipramine binding and response to minaprine in patients with major depression. Pharmacopsychiatry. 21:(2):1988;101-104.
11. Arora R.C., Meltzer H.Y. Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatr. 146:1989;730-736.
12. Pandey G.N., Pandey S.C., Janicak P.G., Marks R.C., Davis J. Platelet serotonin-2 receptor sites in depression and suicide. Biol Psychiatry. 28:1990;215-222.
13. 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age. Psychiatr Res. 51:1993;147-155.
14. Sheline Y.I., Bardgett M.E., Jackson J.L., Newcomer J., Csernansky J. Platelet serotonin markers and depressive symptomatology. Biol Psychiatry. 37:1995;442-447.
15. Sheline Y.I., Black K.J., Bardgett M.E., Csernansky J.G. Platelet binding characteristics distinguish placebo responders from nonresponders in depression. Neuropsychopharmacology. 12:1995;315-322.
16. Gentsch C., Lichtsteiner M., Gatspar M., Gatspar G., Feer H. 3H-Imipramine binding sites in platelets of hospitalized psychiatric patients. Psychiatr Res. 14:(3):1985;177-181.
17. Roy A., Everett D., Picar D., Paul S.M. Platelet tritiated imipramine binding and serotonin uptake in depressed patients and controls. Arch Gen Psychiatry. 44:1987;320-327.
18. 3H-paroxetine binding to platelet and neuronal membranes. Eur J Pharmacol. 119:1985;1-8.
19. 2-receptors. J Psychiatr Neurosci. 20:1995;11-19.
20. 2A receptors unchanged by antidepressant treatment. Psychiatr Res. 66:1997;73-86.
21. Löwry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.
22. Scatchard G. The attractions of protein for small molecules and ions. Ann NY Acad Sci. 51:1949;660-672.
23. Bylund D.B., Yamamura H.I. Methods for receptor binding. Yamamura H.I., Enna S.J., Kuhar M.J. Methods in neurotransmitter receptor analysis. 1990;1-35 Raven Press, New York.
24. 3H-paroxetine to human platelet membranes. Eur J Pharmacol. 96:1983;303-309.
25. 3H-paroxetine. Psychopharmacology (Berl). 110:1993;235-239.
26. Nankai M., Yamada S., Yoshimoto S., Watanabe A., Mori H., Asai K., Aoru M. Platelet 3H-paroxetene bindings in control subjects and depressive patient relationship to serotonin uptake and age. Pediatr Res. 51:1994;147-155.
27. 3H-paroxetine binding to human platelets. J Affec Disord. 50:1998;11-15.
28. Bakish D., Cavazzoni P., Chudzik J., Ravindran A., Hrdina P.D. Effects of selective serotonin reuptake inhibitors on platelets serotonin parameters in major depressive disorder. Biol Psychiatry. 41:1997;184-190.
29. 3H-paroxetine binding correlate with recurrence of suicidal behavior. Psychopharmacology (Berl). 132:1997;89-94.
30. 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference. Biol Psychiatry. 28:1990;509-517.
31. Zadina J.E., Hackler L., Ge L.J., Kastin A.J. A potent and selective endogenous agonist to the μ-opiate receptor. Nature. 386:1997;499-502.