Dose responses for the formation of hemoglobin adducts and urinary metabolites in rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-14C]-butadiene

Chemico-Biological Interactions

Volumn 147, Issue 2, 2004, Pages 213-232

  Booth, Ewan D ^a   Kilgour, Joanne D ^a   Watson, William P ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Butadiene; Hemoglobin adducts; Species differences; Urinary metabolites

Indexed keywords

1 (N ACETYLCYSTEIN S YL) 2 HYDROXYBUT 3 ENE; 1,2 EPOXY 3 BUTENE; 1,3 BUTADIENE DERIVATIVE; 2 (N ACETYLCYSTEIN S YL) 1 HYDROXYBUT 3 ENE; 4 (N ACETYLCYSTEIN S YL) 1,2 DIHYDROXYBUTANE; ALKENE DERIVATIVE; BUTANE; CARBON 14; EPOXIDE HYDROLASE; GLUTATHIONE; HEMOGLOBIN; N (1,2,3 TRIHYDROXYBUT 4 YL)VALINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE; GAS CHROMATOGRAPHY; HYDROLYSIS; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RADIOACTIVITY; RAT; RAT STRAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINARY EXCRETION;

ADMINISTRATION, INHALATION; ANIMALS; BUTADIENES; CARBON RADIOISOTOPES; CARCINOGENS, ENVIRONMENTAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HEMOGLOBINS; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY; SCINTILLATION COUNTING; SPECIES SPECIFICITY; VALINE;

ANIMALIA;

EID: 1542375854     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.01.002     Document Type: Article

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