Tissue-specific dysregulation of cortisol metabolism in equine laminitis

Equine Veterinary Journal

Volumn 36, Issue 1, 2004, Pages 41-45

  Johnson, P J ^a   Ganjam, V K ^a   Slight, S H ^a   Kreeger, J M ^a   Messer, N T ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

11 hydroxysteroid dehydrogenase; Cortisol; Cortisone; Glucocorticoid; Horse; Integument; Laminitis

Indexed keywords

11 KETOREDUCTASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; HYDROCORTISONE; OXIDOREDUCTASE; STARCH; STEROID; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL TEST; FEMALE; HORMONE METABOLISM; INFLAMMATION; LAMELLAR BODY; LAMINITIS; MALE; MOLECULAR MECHANICS; NASOGASTRIC TUBE; NONHUMAN; PATHOGENESIS; RADIOMETRY; REGULATORY MECHANISM; SKIN; TISSUE SPECIFICITY;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 1542364562     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/0425164044864750     Document Type: Article

References (24)

1. Angeli, A., Masera, R.G., Sartori, M.L., Fortunati, N., Racca, S., Dovio, A., Staurenghi, A. and Frairia, R. (1999) Modulation by cytokines of glucocorticoid action. Ann. NY Acad. Sci. 876, 210-220.
2. Brem, A.S. and Morris, D.J. (1993) Interactions between glucocorticoids and mineralocorticoids in the regulation of renal electrolyte transport. Mol. Cell. Endocrinol. 97, C1-C5.
3. Eyre, P., Elmes, P.J. and Strickland, S. (1979) Corticosteroid- potentiated vascular responses of the equine digit: a possible pharmacologic basis for laminitis. Am. J. vet. Res. 40, 135-138.
4. Fontaine, G.L., Belknap, J.K., Allen, D., Moore, J.N. and Kroll, D.L. (2001) Expression of interleukin-1beta in the digital laminae of horses in the prodromal stage of experimentally induced laminitis. Am. J. vet. Res. 62, 714-720.
5. Funder, J.W., Pearce, P.T., Smith, R. and Smith, A.I. (1988) Mineralocorticoid action: target-tissue specificity is enzyme, not receptor, mediated. Science 242, 583-585.
6. Funder, J.W., Pearce, P.T., Myles, K. and Roy, L.P. (1990) Apparent mineralocorticoid excess, pseudohypoaldosteronism and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action. FASEB J. 4, 3234-3238.
7. Ganjam, V.K., Zhou, M.Y., Johnson, P.J., Chen, Y.J. and Gomez-Sanchez, C.E. (1999) 11-beta-hydroxysteroid dehydrogenase in the horse. In: Proceedings of the 81st Annual Meeting of the Endocrine Society, San Diego, California (Abstr. No. P2-263).
8. Ganjam, V.K., Chen, Y., Johnson, P.J., Gomez-Sanchez, E.P. and Gomez-Sanchez, C.E. (2000) A novel high affinity 11β-hydroxysteroid oxidoreductase in the horse liver. In: Proceedings of the 82nd Annual Meeting of the Endocrine Society, Toronto, Canada (Abstr. No. 1548).
9. Garner, H.E., Coffman, J.R., Hahn, A.W., Salem, C. and Johnson, J.A. (1975) Equine laminitis of alimentary origin: an experimental model. Am. J. vet. Res. 36, 441-444.
10. Johnson, P.J., Slight, S.H., Ganjam, V.K. and Kreeger, J.M. (2002) Glucocorticoids and laminitis in the horse. Vet. Clin. N. Am.: Equine Pract. 18, 219-236.
11. Johnson, P.J., Tyagi, S.C., Katwa, L.C., Ganjam, V.K., Moore, L.A., Kreeger, J.M. and Messer, N.T. (1998) Activation of extracellular matrix metalloproteinases in equine laminitis. Vet. Rec. 142, 392-396.
12. Katwa, L.C., Johnson, P.J., Ganjam, V.K., Kreeger, J.M. and Messer, N.T. (1999) Expression of endothelin in equine laminitis. Equine vet. J. 31, 243-247.
13. Masuzaki, H., Paterson, J., Shinyama, H., Morton, N.M., Mullins, J.J., Seckl, J.R. and Flier, J.S. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294, 2166-2170.
14. Mellor, D.J., Stafford, K.J., Todd, S.E., Lowe, T.E., Gregory, N.G., Bruce, R.A. and Ward, R.N. (2002) A comparison of catecholamine and cortisol responses of young lambs and calves to painful husbandry procedures. Aust. vet. J. 80, 228-233.
15. Monder, C. (1991) Corticosteroids, kidneys, sweet roots and dirty drugs. Mol. Cell. Endocrinol. 78, C95-C98.
16. Obel, N. (1948) Studies on the Histopathology of Acute Laminitis, Almqvist and Wiksells, Boktryckeri ab Uppsala.
17. Penning, T.M. (1997) Molecular endocrinology of hydroxysteroid dehydrogenase. Endocr. Rev. 18, 281-305.
18. Pollitt, C.C. (1996) Basement membrane pathology: a feature of acute equine laminitis. Equine vet. J. 28, 38-46.
19. Rask, E., Olsson, T., Soderberg, S., Andrew, R., Livingstone, D.E.W., Johnson, O. and Walker, B.R. (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J. Clin. Endocrinol. Metabol. 86, 1418-1421.
20. Roberts, E.D., Ochoa, R. and Haynes, P.F. (1980) Correlation of dermal-epidermal laminar lesions of equine hoof with various disease conditions. Vet. Pathol. 17, 656-666.
21. Seckl, J.R. and Chapman, K.E. (1997) The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action. Eur. J. Biochem. 249, 361-364.
22. Stewart, P.M. and Krozowski, Z.S. (1999) 11β-hydroxysteroid dehydrogenase. Vitamins Hormones 57, 249-324.
23. White, P.C., Mune, T. and Agarwal, A.K. (1997) 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocrin. Rev. 18, 135-156.
24. Yang, K. and Yu, M. (1994) Evidence for distinct isoforms of 11 beta-hydroxysteroid dehydrogenase in the ovine liver and kidney. J. Steroid Biochem. Mol. Biol. 49, 245-250.