A Prospective Randomized Study on Two Dose Fractionation Regimens of High-Dose-Rate Brachytherapy for Carcinoma of the Uterine Cervix: Comparison of Efficacies and Toxicities between Two Regimens

Journal of Korean Medical Science

Volumn 19, Issue 1, 2004, Pages 87-94

  Nam, Taek Keun ^a   Ahn, Sung Ja ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Brachytherapy; Cervix neoplasms; Dose fractionation; Prospective studies

Indexed keywords

CISPLATIN; FLUOROURACIL;

ABDOMINAL PAIN; ADULT; AGED; ANEMIA; ARTICLE; BLADDER DISEASE; BRACHYTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTOVAGINAL FISTULA; DIARRHEA; DYSURIA; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; INTERMETHOD COMPARISON; LEUKOPENIA; MAJOR CLINICAL STUDY; NAUSEA; NEUTROPENIA; PELVIS RADIOGRAPHY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; RECTOVAGINAL FISTULA; RECTUM DISEASE; RECTUM HEMORRHAGE; SAFETY; SURVIVAL RATE; TOXICITY; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA; VOMITING;

EID: 1542350063     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2004.19.1.87     Document Type: Article

References (30)

1. Ministry of Health and Welfare. Annual report of the Korea Central Cancer Registry Program: Based on registered data from 134 hospitals, January-December, 2001. Korea, 2002.
2. Fu KK, Phillips TL. High-dose-rate versus low-dose-rate intracavitary brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1990; 19: 791-6.
3. Patel FD, Sharma SC, Negi PS, Ghoshal S, Gupta BD. Low dose rate vs. high dose rate brachytherapy in the treatment of carcinoma of the uterine cervix: a clinical trial. Int J Radiat Oncol Biol Phys 1994; 28: 335-41.
4. Huh SJ. Current status of high dose rate brachytherapy in cervical cancer in Korea and optimal treatment schedule. J Korean Soc Ther Radiol Oncol 1998; 16: 357-66.
5. Nag S, Erickson B, Thomadsen B, Orton C, Demanes JD, Petereit D. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys 2000; 48: 201-11.
6. Lee SW, Suh CO, Chung EJ, Kim GE. Dose optimization of fractionated external radiation and high-dose-rate intracavitary brachytherapy for FIGO stage IB uterine cervical carcinoma. Int J Radiat Oncol Biol Phys 2002; 52: 1338-44.
7. Sood BM, Gorla G, Gupta S, Garg M, Deore S, Runowicz CD, Fields AL, Goldberg GL, Anderson PS, Vikram B. Two fractions of high-dose-rate brachytherapy in the management of cervix cancer: clinical experience with and without chemotherapy. Int J Radiat Oncol Biol Phys 2002; 53: 702-6.
8. Ferrigno R, dos Santos Novaes PE, Pellizzon AC, Maia MA, Fogarolli RC, Gentil AC, Salvajoli JV. High-dose-rate brachytherapy in the treatment of uterine cervix cancer. Analysis of dose effectiveness and late complications. Int J Radiat Oncol Biol Phys 2001; 50: 1123-35.
9. Le Pechoux C, Akine Y, Sumi M, Tokuuye K, Ikeda H, Yajima M, Yamada T, Tanemura K, Tsunematsu R, Ohmi K. High dose rate brachytherapy for carcinoma of the uterine cervix: comparison of two different fractionation regimens. Int J Radiat Oncol Biol Phys 1995; 31: 735-41.
10. Wong FC, Tung SY, Leung TW, Sze WK, Wong VY, Lui CM, Yuen KK, O SK. Treatment results of high-dose-rate remote afterloading brachytherapy for cervical cancer and retrospective comparison of two regimens. Int J Radiat Oncol Biol Phys 2003; 55: 1254-64.
11. Chatani M, Matayoshi Y, Masaki N, Teshima T, Inoue T. A prospective randomized study concerning the point A dose in high-dose rate intracavitary therapy for carcinoma of the uterine cervix. The final results. Strahlenther Onkol 1994; 170: 636-42.
12. Dale RG. The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol 1985; 58: 515-28.
13. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989; 62: 679-94.
14. ICRU Report 38. Dose and volume specification for reporting intracavitary therapy in gynecology. International commission on radiation units and measurements 1985: 1-20.
15. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-6.
16. Stitt JA, Fowler JF, Thomadsen BR, Buchler DA, Paliwal BP, Kinsella TJ. High dose rate intracavitary brachytherapy for carcinoma of the cervix: the Madison system: I. Clinical and radiobiological considerations. Int J Radiat Oncol Biol Phys 1992; 24: 335-48.
17. Orton CG. High-dose-rate brachytherapy may be radiobiologically superior to low-dose rate due to slow repair of late-responding normal tissue cells. Int J Radiat Oncol Biol Phys 2001; 49: 183-9.
18. Nag S, Orton C, Young D, Erickson B. The American brachytherapy society survey of brachytherapy practice for carcinoma of the cervix in the United States. Gynecol Oncol 1999; 73: 111-8.
19. Petereit DG, Pearcey R. Literature analysis of high dose rate brachytherapy fractionation schedules in the treatment of cervical cancer: is there an optimal fractionation schedule? Int J Radiat Oncol Biol Phys 1999; 43: 359-66.
20. Nag S, Gupta N. A simple method of obtaining equivalent doses for use in HDR brachytherapy. Int J Radiat Oncol Biol Phys 2000; 46: 507-13.
21. Clark BG, Souhami L, Roman TN, Chappell R, Evans MD, Fowler JF. The prediction of late rectal complications in patients treated with high dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1997; 38: 989-93.
22. Toita T, Kakinohana Y, Ogawa K, Adachi G, Moromizato H, Nagai Y, Maehama T, Sakumoto K, Kanazawa K, Murayama S. Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: analysis of dose and fractionation schedule. Int J Radiat Oncol Biol Phys 2003; 56: 1344-53.
23. Ogino I, Kitamura T, Okamoto N, Yamasita K, Aikawa Y, Okajima H, Matsubara S. Late rectal complication following high dose rate intracavitary brachytherapy in cancer of the cervix. Int J Radiat Oncol Biol Phys 1995; 31: 725-34.
24. Potter R, Van Limbergen E, Gerstner N, Wambersie A. Survey of the use of the ICRU 38 in recording and reporting cervical cancer brachytherapy. Radiother Oncol 2001; 58: 11-8.
25. Kapp KS, Stuecklschweiger GF, Kapp DS, Poschauko J, Pickel H, Hackl A. Carcinoma of the cervix: analysis of complications after primary external beam radiation and Ir-192 HDR brachytherapy. Radiother Oncol 1997; 42: 143-53.
26. Van Lancker M, Storme G. Prediction of severe late complications in fractionated, high dose-rate brachytherapy in gynecological applications. Int J Radiat Oncol Biol Phys 1991; 20: 1125-9.
27. Uno T, Itami J, Aruga M, Kotaka K, Fujimoto H, Sato T, Minoura S, Ito H. High dose rate brachytherapy for carcinoma of the cervix: risk factors for late rectal complications. Int J Radiat Oncol Biol Phys 1998; 40: 615-21.
28. Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, Clarke-Pearson DL, Insalaco S. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 1999; 340: 1144-53.
29. Whitney CW, Sause W, Bundy BN, Malfetano JH, Hannigan EV, Fowler WC Jr., Clarke-Pearson DL, Liao SY. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 1999; 17: 1339-48.
30. Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, Rotman M, Gershenson DM, Mutch DG. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 1999; 340: 1137-43.