Pergolide, Terguride and N,N′-spacer-linked Oligomers of Both Interact with 5-HT2A Receptors of Rat Tail Artery

Physiological Research

Volumn 53, Issue 1, 2004, Pages 35-43

  Křen, Vladimír ^a   Eich, E ^b   Pertz, H H ^b  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

5 HT2A receptors; Contraction; Oligomers of pergolide and terguride; Pergolide; Rat tail artery; Terguride

Indexed keywords

DIMER; KETANSERIN; NITROGEN; OLIGOMER; PERGOLIDE; SEROTONIN 2A RECEPTOR; TERGURIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; TAIL ARTERY;

ANIMALS; ARTERIES; DIMERIZATION; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LISURIDE; MALE; PEPTIDE FRAGMENTS; PERGOLIDE; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN; TAIL; VASOCONSTRICTION;

EID: 1542346060     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. 2 receptors. Life Sci 49: 925-930, 1991.
2. FURCHGOTT RF: The classification of adrenoceptors (adrenergic receptors) An evaluation from the standpoint of receptor theory. In: Catecholamines. H BLASCHKO, E MUSCHOLL (eds), Handbook of Experimental Pharmacology Vol 33, Springer, Berlin, 1972, pp 283-335.
3. 2 cortical receptors. Biol Signals 3: 223-229, 1994.
4. 1B/1D agonists. J Med Chem 39: 4920-4927, 1996.
5. KŘEN V, WEIGNEROVA L, KUZMA M, JEGOROV A, SEDMERA P: Semisynthetic dimers of antiparkinsonic ergot alkaloids. Heterocycles 55: 1045-1056, 2001.
6. KŘEN V, FIŠEROVA A, WEIGNEROVÁ L, STIBOR I, HALADA P, PǨIKRYLOVÁ V, SEDMERA P, POSPÍŠIL M: Clustered ergot alkaloids modulate cell-mediated cytotoxity. Bioorg Med Chem 10: 415-424, 2002.
7. MARANO M, KAUMANN AJ: On the statistics of drug-receptor constants for partial agonists J Pharmacol Exp Ther 198: 518-525, 1976.
8. 1B/1D receptor subtypes. Bioorg Med Chem Lett 8: 1407-1412, 1998.
9. PERTZ H, EICH E: Ergot alkaloids and their derivatives as ligands for serotoninergic, dopaminergic, and adrenergic receptors. In: Ergot, the Genus Claviceps. V KŘEN, L CVAK (eds), Harwood Academic Publishers, Amsterdam, 1999, pp 411-440.
10. 2A receptor affinity. J Med Chem 42: 659-668, 1999.
11. PORTOGHESE PS: Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists. Trends Pharmacol Sci 10: 230-235, 1989.
12. PORTOGHESE PS: The role of concepts in structure-activity relationship studies of opioid ligands. J Med Chem 35: 1927-1937, 1992.
13. RINNE UK: Dopamine agonists as primary treatment in Parkinson's disease. Adv Neurol 45: 519-523, 1987.
14. STANDAERT DG, YOUNG AB: Treatment of central nervous system degenerative disorders. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, 1995, pp 503-519.
15. 2 partial agonist, terguride. Behav Pharmacol 1: 521-529, 1990.