Influence of Catabolite Repression and Inducer Exclusion on the Bistable Behavior of the lac Operon

Biophysical Journal

Volumn 86, Issue 3, 2004, Pages 1282-1292

  Santillán, Moisés ^a,b,c   Mackey, Michael C ^a  

^a MCGILL UNIVERSITY   (Canada)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYCLIC AMP; CYCLIC AMP BINDING PROTEIN; GLUCOSE; LACTOSE; MESSENGER RNA; PERMEASE; RNA POLYMERASE;

ARTICLE; BACTERIAL GROWTH; CATABOLITE REPRESSION; COMPUTER MODEL; CONTROLLED STUDY; ENERGY; ESCHERICHIA COLI; HYSTERESIS; LACTOSE OPERON; MATHEMATICAL MODEL; NONHUMAN; PROMOTER REGION; RIBOSOME; RNA DEGRADATION; RNA TRANSCRIPTION; RNA TRANSLATION; TIME; TRANSCRIPTION INITIATION; TRANSLATION INITIATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 1542335822     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(04)74202-2     Document Type: Article

References (36)

1. Ackers, G. K., A. D. Johnson, and M. A. Sea. 1982. Quantitative model for gene regulation by λ phage repressor. Proc. Natl. Acad. Sci. USA. 79:1129-1133.
2. Anderson, W. B., A. B. Schneider, M. Emmer, R. L. Perlman, and I. Pastan. 1971. Purification of and properties of the cyclic adenosine 3′,5′-monophosphate receptor protein which mediates 3′,5′-monophosphate dependent gene transcription in Escherichia coli. J. Biol. Chem. 246:5929-5937.
3. Baker, C. H., S. R. Tomlinson, A. E. García, and J. G. Harman. 2001. Amino acid substitution at position 99 affects the rate of CRP subunit exchange. Biochemistry. 40:12329-12338.
4. Beckwith, J. 1987. The lactose operon. In Escherichia coli and Salmonella thyphymurium: Cellular and Molecular Biology, Vol. 2. F. C. Neidhart, J. L. Ingraham, K. B. Low, B. Magasanik, and H. E. Umbarger, editors. American Society for Microbiology, Washington, DC. 1439-1443.
5. Bremer, H., and P. P. Dennis. 1996. Modulation of chemical composition and other parameters of the cell by growth rate. In Escherichia coli and Salmonella thyphymurium: Cellular and Molecular Biology, Vol. 2. F. C. Neidhart, R. Curtis, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger, editors. American Society for Microbiology, Washington, DC. 1553-1569.
6. Casadesús, J., and R. D'Ari. 2002. Memory in bacteria and phage. Bioessays. 24:512-518.
7. Dean, A. M. 1989. Selection and neutrality in lactose operons of Escherichia coli lactose promoter. Genetics. 123:441-454.
8. Donnelly, C. E., and W. S. Reznikoff. 1987. Mutations in the lac P2 promoter. J. Bacteriol. 169:1812-1817.
9. Draper, D. E. 1996. Translational initiation. In Escherichia coli and Salmonella thyphymurium: Cellular and Molecular Biology, Vol. 1. F. C. Neidhart, R. Curtis, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger, editors. American Society for Microbiology, Washington, DC. 902-908.
10. Epstein, W., L. B. Rothman-Denes, and J. Hesse. 1975. Adenosine 3′:5′-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. Proc. Natl. Acad. Sci. USA. 72:2300-2304.
11. Eschenlauer, A. C., and W. S. Reznikoff. 1991. Escherichia coli catabolite gene activator protein mutants defective in positive control of lac operon transcription. J. Bacteriol. 173:5024-5029.
12. Falcon, C. M., and K. S. Matthews. 2000. Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor protein. Biochemistry. 39:11074-11083.
13. Ferrell, J. E. 2002. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback, and bistability. Curr. Opin. Chem. Biol. 6:140-148.
14. Gilbert, W., and B. Müller-Hill. 1966. Isolation of the lac repressor. Proc. Natl. Acad. Sci. USA. 56:1891-1898.
15. Hudson, J. M., and M. G. Fried. 1991. The binding of cyclic AMP receptor protein to two lactose promoter sites is not cooperative in vitro. J. Bacteriol. 173:59-66.
16. Jobe, A., and S. Bourgeois. 1972. lac repressor-operator interaction. VI. The natural inducer of the lac operon. J. Mol. Biol. 69:397-408.
17. Kennell, D., and H. Riezman. 1977. Transcription and translation initiation frequencies of the Escherichia coli lac operon. J. Mol. Biol. 114:1-21.
18. Knorre, W. A. 1968. Oscillation of the rate of synthesis of β-galactosidase in Escherichia coli ML 30 and ML 308. Biochem. Biophys. Res. Commun. 30:1248-1290.
19. Laurent, M., and N. Kellershohn. 1999. Multistability: a major means of differentiation and evolution in biological systems. Trends Biochem. Sci. 24:418-422.
20. Lolkema, J., N. Carrasco, and H. Kaback. 1991. Kinetic analysis of lactose exchange in proteoliposomes reconstituted with purified lac permease. Biochemistry. 30:1284-1290.
21. Malan, T. P., A. Kolb, H. Buc, and W. R. McClure. 1984. Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter. J. Mol. Biol. 180:881-909.
22. Mandelstam, J. 1957. Turnover of protein in starved bacteria and its relationship to the induced synthesis of enzyme. Nature. 179:1179-1181.
23. Martínez-Bilbao, M., R. E. Holdsworth, R. A. Edwards, and R. E. Huber. 1991. A highly reactive β-galactosidase (Escherichia coli) resulting from a substitution of an aspartic acid for Gly-794. J. Biol. Chem. 266:4979-4986.
24. Notley, L., and T. Ferenci. 1995. Differential expression of mal genes under cAMP and endogenous inducer control in nutrient-stressed Escherichia coli. Mol. Microbiol. 16:121-129.
25. Novick, A., and M. Wiener. 1957. Enzyme induction as an all-or-none phenomenon. Proc. Natl. Acad. Sci. USA. 43:553-566.
26. Oehler, S., M. Amouyal, P. Kolkhof, B. von Wilcken-Bergmann, and B. Müller-Hill. 1994. Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J. 13:3348-3355.
27. Peterson, M. L., and W. S. Reznikoff. 1985. Properties of lac P2 in vivo and in vitro. An overlapping RNA polymerase binding site within the lactose promoter. J. Mol. Biol. 185:535-543.
28. Pyles, E. A., and J. C. Lee. 1996. Mode of selectivity in cyclic AMP receptor protein-dependent promoters in Escherichia coli. Biochemistry. 35:1162-1172.
29. Reznikoff, W. S. 1992. The lactose operon-controlling elements: a complex paradigm. Mol. Microbiol. 6:2419-2422.
30. Savageau, M. A. 1999. Design of gene circuitry by natural selection: analysis of the lactose catabolic system in Escherichia coli. Biochem. Soc. Trans. 27:264-270.
31. von Hippel, P. H., A. Revzin, C. A. Gross, and A. C. Wang. 1974. Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspects. Proc. Natl. Acad. Sci. USA. 71:4808-4812.
32. Vossen, K. M., D. F. Stickle, and M. G. Fried. 1996. The mechanisms of CAP-lac repressor binding cooperativity at the E. coli lactose promoter. J. Mol. Biol. 255:44-54.
33. Winkler, H., and T. Wilson. 1967. Inhibition of β-galactosidase transport by substrates of the glucose transport system in Escherichia coli. Biochim. Biophys. Acta. 135:1030-1051.
34. Wong, P., S. Gladney, and J. D. Keasling. 1997. Mathematical model of the lac operon: inducer exclusion, catabolite repression, and diauxic growth on glucose and lactose. Biotechnol. Prog. 13:132-143.
35. Yagil, G., and E. Yagil. 1971. On the relation between effector concentration and the rate of induced enzyme synthesis. Biophys. J. 11: 11-27.
36. Yildirim, N., and M. C. Mackey. 2003. Feedback regulation in the lactose operon: a mathematical modeling study and comparison with experimental data. Biophys. J. 84:2841-2851.