Synthesis of novel 2-nitroimidazole-tethered tricyclic quinolines, bearing a second heteroatom, and their in vitro evaluation as hypoxia-selective cytotoxins and radiosensitizers

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 6, 2004, Pages 1523-1525

  Papadopoulou, Maria V ^a   Rosenzweig, Howard S ^a   Bloomer, William D ^a  

^a EVANSTON NORTHWESTERN HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 [3 (2 NITROIMIDAZOLYL)PROPYLAMINO] 2 METHYL 1,2,3,4 TETRAHYDROBENZO[B] 1,6 NAPHTHYRIDINE; 10 [3 (2 NITROIMIDAZOLYL)PROPYLAMINO] 3,4 DIHYDRO 1H THIOPYRANO[4,3 B]QUINOLINE; 9 [3 (2 NITRO 1 IMIDAZOLYL)PROPYLAMINO] 1,2,3,4 TETROACRIDINE; CYTOTOXIN; RADIOSENSITIZING AGENT; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; GENE TARGETING; HYPOXIA; INTERCALATION COMPLEX; LUNG FIBROBLAST; NONHUMAN;

ANIMALS; CELL HYPOXIA; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS; INTERCALATING AGENTS; NITROIMIDAZOLES; QUINOLINES; RADIATION-SENSITIZING AGENTS;

EID: 1542314923     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.102     Document Type: Article

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