Nociceptive spinal neurons expressing NK1 and GABAB receptors are located in lamina I

Brain Research

Volumn 1003, Issue 1-2, 2004, Pages 77-85

  Castro, Ana Rita ^a   Pinto, Marta ^a   Lima, Deolinda ^a   Tavares, Isaura ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b Institute of Histology and Embryology   (Portugal)

Author keywords

c fos; GABA; Pain; Pain modulation: anatomy and physiology; Rat; Sensory systems; Spinal cord; Substance P; Triple immunostaining

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; NEUROKININ 1 RECEPTOR; PROTEIN FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; IMMUNODETECTION; IMMUNOHISTOCHEMISTRY; MALE; MECHANICAL STIMULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; RAT; SKIN STIMULATION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINDLE CELL;

ANIMALS; IMMUNOHISTOCHEMISTRY; MALE; PAIN; PAIN MEASUREMENT; POSTERIOR HORN CELLS; RATS; RATS, WISTAR; RECEPTORS, GABA-B; RECEPTORS, NEUROKININ-1; SPINAL NERVES;

EID: 1542298862     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2003.12.027     Document Type: Article

References (57)

1. A receptors and excitatory amino acids in the mouse spinal cord. J. Pharmacol. Exp. Ther. 248:1989;1034-1038.
2. Almeida A., Lima D. Activation by cutaneous or visceral noxious stimulation of spinal neurons projecting to the medullary dorsal reticular nucleus in the rat: a c-fos study. Eur. J. Neurosci. 9:1997;686-695.
3. Barker J.L., Nicoll R.A. Gamma-aminobutyric acid: role in primary afferent depolarization. Science. 175:1972;1043-1045.
4. Basbaum A.I. Distinct neurochemical features of acute and persistent pain. Proc. Natl. Acad. Sci. 96:1999;7739-7743.
5. Bowery N.G., Price G.W., Hudson A.L., Hill D.R., Wilkin G.P., Turnbull M.J. GABA receptor multiplicity - visualization of different receptor types in the mammalian CNS. Neuropharmacology. 23:1984;219-231.
6. B receptor site distribution in the rat central nervous system. Neuroscience. 20:1987;365-383.
7. Björkman R., Hallman K.M., Hedner J., Hedner T., Henning M. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain. 57:1994;259-264.
8. B receptors in the rat olfactory bulb. Neurosci. Lett. 274:1999;195-198.
9. B receptor-mediated events to inflammatory pain processing: carrageenan oedema and associated spinal c-fos expression in the rat. Neuroscience. 73:1996;487-496.
10. Castro A.R., Bowery N., Castro-Lopes J. Baclofen and midazolam alter c-fos induction by peripheral noxious or innocuous stimulation in the spinal cord of normal and monoarthritic rats. Neuropharmacology. 38:1999;1775-1788.
11. B- receptors in the rat. Abstracts of the 10th World Congress on Pain. 2002;519 IASP Press, Seattle.
12. B2 subunits in rat brain spinal cord and dorsal root ganglion. Neuroscience. 106:2001;447-467.
13. Cheunsuang O., Morris R. Spinal lamina I neurons that express neurokinin 1 receptors: morphological analysis. Neuroscience. 97:2000;335-345.
14. Cheunsuang O., Maxwell D., Morris R. Spinal lamina I neurones that express neurokinin 1 receptors: II. Electrophysiological characteristics, responses to primary afferent stimulation and effects of a selective mu-opioid receptor agonist. Neuroscience. 111:2002;423-434.
15. Donovick J.P. A metachromatic stain for neural tissue. Stain Technol. 49:1974;49-51.
16. Doyle C.A., Hunt S.P. Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: a c-fos study in rat. Neuroscience. 89:1999;17-28.
17. Eccles J.C., Schmidt R., Willis W.D. Pharmacological studies on presynaptic inhibition. J. Physiol. 168:1964;500-530.
18. Everitt B.S. The Analysis of Contingency Tables. 1977;Chapman & Hall, New York.
19. Gamboa-Esteves F.O., Kaye J.C., McWilliam P.N., Lima D., Batten T.F.C. Immunohistochemical profiles of spinal lamina I neurones retrogradely labelled from the nucleus tractus solitarii in the rat suggest excitatory projections. Neuroscience. 104:2001;523-538.
20. B receptor subunits in rat visual cortex. J. Comp. Neurol. 431:2001;182-197.
21. Hammond D.L., Drower E.J. Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold. Eur. J. Pharmacol. 103:1984;121-125.
22. Hammond D.L., Washinghton J.D. Antagonism of L-baclofen-induced antinociception by CGP35348 in the spinal cord of the rat. Eur. J. Pharmacol. 234:1993;255-262.
23. Han Z.S. Nociceptive and thermoreceptive lamina I neurons are anatomically distinct. Nat. Neurosci. 1:1998;218-225.
24. Henry J.L. Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 114:1976;439-451.
25. Hunt S.P. Pain control: breaking the circuit. TIPS. 21:2000;284-286.
26. Hunt S.P., Manthy P.W. The molecular dynamics of pain control. Nat. Rev., Neurosci. 2:2001;83-91.
27. Kangrga I., Jiang M., Randic M. Actions of (-)-baclofen on rat dorsal horn neurons. Brain Res. 562:1991;265-275.
28. Lima D. Functional anatomy of spinofugal nociceptive pathways. Pain Rev. 4:1997;1-19.
29. Lima D., Coimbra A. The neuronal population of the marginal zone (laminaI) of the rat spinal cord, A study based on reconstructions of serially sectioned cells. Anat. Embryol. 167:1983;273-288.
30. Lima D., Coimbra A. A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord. J. Comp. Neurol. 244:1986;53-71.
31. Lin Q., Peng Y.B., Willis W.D. Role of GABA receptors subtypes in inhibition of primate spinothalamic tract neurons: difference between spinal and periaqueductal gray inhibition. J. Neurophysiol. 75:1996;109-123.
32. Littlewood N.K., Todd A.J., Spike R.C., Watt C., Shehab S.A.S. The types of neurons in spinal dorsal horn which possess neurokinin-1 receptors. Neuroscience. 66:1995;597-608.
33. Liu H., Brown J.L., Jasmin L., Maggio J.E., Vigna S.R., Mantyh P.W., Basbaum A.I. Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc. Natl. Acad. Sci. U. S. A. 91:1994;1009-1013.
34. Malcangio M., Bowery N.G. Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro. J. Pharmacol. Exp. Ther. 266:1993;1490-1496.
35. Malcangio M., Bowery N.G. GABA and its receptors in the spinal cord. TIPS. 17:1996;457-462.
36. B antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. Br. J. Pharmacol. 103:1991;1303-1308.
37. Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked. Science. 257:1992;1276-1279.
38. Mantyh P.W., Demaster E., Malhotra A., Ghilard J.R., Rogers S.D., Mantyh C.R., Liu H., Basbaum A.I., Vigna S.R., Maggio J.E., Simone D.A. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 268:1995;1629-1632.
39. B receptors in the rat central nervous system. J. Comp. Neurol. 405:1999;299-321.
40. Marshall G.E., Shehab S.A.S., Spike R.C., Todd A.J. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat. Neuroscience. 72:1996;255-263.
41. Molander C., Xu Q., Grant G. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J. Comp. Neurol. 230:1984;133-141.
42. B, μ-opioid and NK1-receptors. Eur. J. Neurosci. 17:2003;1393-1402.
43. Randic M., Miletic V. Effect of substance P in cat dorsal horn neurones activated by noxious stimuli. Brain Res. 128:1977;164-169.
44. Ren K., Dubner R. Descending modulation in persistent pain: an update. Pain. 100:2002;1-6.
45. Ren K., Zhuo M., Willis W.D. Multiplicity and plasticity of descending modulation of nociception: implications for persistent pain. Devor M., Rowbotham M.C., Wiesenfeld-Hallin Z. Proceedings of the 9th World Congress on Pain. 2000;387-400 IASP Press, Seattle.
46. A receptor activation. Neuroscience. 103:2001;725-737.
47. Salter M.W., Henry J.L. Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin. Neuroscience. 43:1991;601-610.
48. Sawynok J., LaBella F.S. On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine. Neuropharmacology. 21:1982;397-403.
49. Snijdelaar D.G., Dirksen R., Slappendel R., Crul B.J.P. Substance P. Eur. J. Pain. 4:2000;121-135.
50. Susuki R., Morcuende S., Webber M., Hunt S.P., Dickenson A. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat. Neurosci. 5:2002;1319-1326.
51. Tavares I., Lima D., Coimbra A. Neurons in the superficial dorsal horn of the rat spinal cord projecting to the medullary ventrolateral reticular formation express c-fos after noxious stimulation of the skin. Brain Res. 623:1993;278-286.
52. Tavares I., Albino-Teixeira A., Lima D. Hypertension inhibits noxious-evoked c-fos expression in the rat spinal cord. NeuroReport. 6:1995;1664-1668.
53. Todd A.J., McGill M.M., Shehab A.S. Neurokinin 1 receptor expression by neurons in Laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur. J. Neurosci. 12:2000;689-700.
54. Todd A.J., Puskár Z., Spike R.C., Hughes C., Watt C., Forrest L. Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance P-containing afferents and respond to noxious stimulation. J. Neurosci. 22:2002;4103-4113.
55. Traub R.J. The spinal contribution of substance P to the generation and maintence of inflammatory hyperalgesia in the rat. Pain. 67:1996;151-161.
56. Yashpal K., Dam T.V., Quirion R. Effects of dorsal rhizotomy on neurokinin receptor sub-types in the rat spinal cord: a quantitative autoradiographic study. Brain Res. 552:1991;240-247.
57. Yu X.H., Zhang E.T., Craig A.D. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. J. Neurosci. 19:1999;3545-3555.