Semi-automated 86Y purification using a three-column system

Nuclear Medicine and Biology

Volumn 31, Issue 2, 2004, Pages 297-301

  Park, Luke S ^a   Szajek, Lawrence P ^b   Wong, Karen J ^a   Plascjak, Paul S ^b   Garmestani, Kayhan ^c   Googins, Shawn ^d   Eckelman, William C ^b   Carrasquillo, Jorge A ^a   Paik, Chang H ^a  

^a Nuclear Medicine Department   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

86Y purification; Aminex A5 resin; RE Spec resin; Semi automation; Sr Spec resin

Indexed keywords

HYDROGEN; NITRITE; NITROGEN DERIVATIVE; OXYGEN DERIVATIVE; STRONTIUM; STRONTIUM 86; UNCLASSIFIED DRUG; YTTRIUM; YTTRIUM 86; BIOTIN; DOTA BIOTIN; DOTA-BIOTIN; DRUG DERIVATIVE; ORGANOMETALLIC COMPOUND; RADIOPHARMACEUTICAL AGENT;

ACCURACY; ANALYTIC METHOD; ARTICLE; AUTOMATION; CHEMICAL WASTE; CONCENTRATION RESPONSE; DISSOLUTION; DRUG PURIFICATION; ELUTION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PHASE SEPARATION; PURIFICATION; QUANTITATIVE ANALYSIS; REACTION OPTIMIZATION; SAMPLING; SEQUENTIAL ANALYSIS; SYSTEM ANALYSIS; CHEMISTRY; CHROMATOGRAPHY; EVALUATION; INSTRUMENTATION; ISOLATION AND PURIFICATION; ISOTOPE LABELING; METHODOLOGY; PROTEIN BINDING; ROBOTICS; SYNTHESIS; VALIDATION STUDY;

BIOTIN; CHROMATOGRAPHY; ISOTOPE LABELING; ORGANOMETALLIC COMPOUNDS; PROTEIN BINDING; RADIOPHARMACEUTICALS; ROBOTICS; STRONTIUM ISOTOPES; YTTRIUM RADIOISOTOPES;

EID: 1542285448     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.07.002     Document Type: Article

References (12)

1. Dietz M.L., Horwitz E.P. Improved chemistry for the production of yttrium-90 for medical applications. Appl Radiat Isot. 43:1992;1093-1101.
2. Finn RD, McDevitt M, Ma D, Jurcic J, Scheinberg D, Larson S, Shoner S, Link J, Krohn K, Schlyer D. Low energy cyclotron production and separation of yttrium-86 for evaluation of monoclonal antibody pharmacokinetics and dosimetry. Applications of Accelerators in Research Industry (1999) 991-993
3. Forster G.J., Engelbach M., Brockmann J., Reber H., Buchholz H.G., Macke H.R., Rosch F., Herzog H., Bartenstein P. Preliminary data on biodistribution and dosimetry for therapy planning of somatostatin receptor positive tumours comparison of Y-86-DOTATOC, and In-111-DTPA-octreotide. Eur J Nucl Med. 28:2001;1743-1750.
4. Garmestani K., Milenic D.E., Plascjak P.S., Brechbiel M.W. A new and convenient method for purification of Y-86 using a Sr (II) selective resin, and comparison of biodistribution of Y-86, and In-111 labeled Herceptin (TM). Nucl Med Biol. 29:2002;599-606.
5. Herzog H., Rosch F., Stocklin G., Lueders C., Qaim S.M., Feinendegen L.E. Measurement of pharmacokinetics of yttrium-86 radiopharmaceuticals with PET and radiation-dose calculation of analogous Y-90 radiotherapeutics. J Nucl Med. 34:1993;2222-2226.
6. Lovqvist A., Humm J.L., Sheikh A., Finn R.D., Koziorowski J., Ruan S., Pentlow K.S., Jungbluth A., Welt S., Lee F.T., Brechbiel M.W., Larson S.M. PET imaging of Y-86-labeled anti-Lewis Y monoclonal antibodies in a nude mouse model comparison between Y-86, and In-111 radiolabels. J Nucl Med. 42:2001;1281-1287.
7. Lundqvist H., Lubberink M., Tolmachev V., Lovqvist A., Sundin A., Beshara S., Bruskin A., Carlsson J., Westlin J.E. Positron emission tomography and radioimmunotargeting - general aspects. Acta Oncol. 38:1999;335-341.
8. Palm S., Enmon R.M., Xu S., Matei C., Kolbert K.S., Borchardt P., Zanzonico P.B., Beattie B., Finn R.D., Larson S.M., Koutcher J.A., Sgouros G. Pharmacokinetics of Y-86-Herceptin in an ovarian carcinoma model Correlative micropet, and MR imaging. J Nucl Med. 43:2002;555.
9. Park L.S., Szajek L.P., Wong K.J., Plascjak P.S., Garmestani K., Googins S., Eckelman W.C., Carrasquillo J.A., Paik C.H. Optimization of a semi-automated Y-86 purification method for clinical use. J Nucl Med. 43:2002;1525.
10. Rosch F., Qaim S.M., Stocklin G. Nuclear-data relevant to the production of the positron emitting radioisotope Y-86 via the Sr-86 (P, N)-processes and (NAT)RB(HE-3, XN)-processes. Radiochim Acta. 61:1993;1-8.
11. Rosch F., Qaim S.M., Stocklin G. Production of the positron emitting radioisotope-Y-86 for nuclear medical application. Appl Radiat Isot. 44:1993;677-681.
12. Rosch F., Herzog H., Stolz B., Brockmann J., Kohle M., Muhlensiepen H., Marbach P., Muller-Gartner H.W. Uptake kinetics of the somatostatin receptor ligand [Y-86] DOTA-DPhe(1)-Tyr(3)-octreotide ([Y-86] SMT487) using positron emission tomography in non-human primates, and calculation of radiation doses of the Y-90-labelled analogue. Eur J Nucl Med. 26:1999;358-366.