Structural identification of extractables from rubber closures used for pre-filled semisolid drug applicator by chromatography, mass spectrometry, and organic synthesis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 34, Issue 5, 2004, Pages 841-849

  Zhang, Fa ^a   Chang, Alan ^a   Karaisz, Ken ^a   Feng, Rong ^b   Cai, Jane ^a  

^a JOHNSON AND JOHNSON   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

2 Bromo 4 (1,1 dimethyl propyl) phenol; Chromatography; Furan 2 yl (5 hydroxymethyl furan 2 yl) methanol; Mass spectrometry; Rubber closures extractables

Indexed keywords

2 BROMO 4 (1,1 DIMETHYLPROPYL)PHENOL; 2,6 DI TERT BUTYL[1,4]BENZOQUINONE; 4 (1,1 DIMETHYLPROPYL)PHENOL; BENZOQUINONE DERIVATIVE; FURAN 2 YL (5 HYDROXYMETHYLFURAN 2 YL)METHANOL; FURAN DERIVATIVE; PHENOL DERIVATIVE; RUBBER; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ANALYSIS; DRUG MANUFACTURE; DRUG STABILITY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

BENZOQUINONES; DRUG CONTAMINATION; DRUG PACKAGING; FURANS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; PHENOL; RUBBER; SULFUR;

EID: 1542272443     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2003.08.003     Document Type: Article

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