The impact of mode of donor brain death on cardiac allograft vasculopathy: An intravascular ultrasound study

Journal of the American College of Cardiology

Volumn 43, Issue 5, 2004, Pages 806-810

  Mehra, Mandeep R ^a,b   Uber, Patricia A ^a   Ventura, Hector O ^a   Scott, Robert L ^a   Park, Myung H ^a  

^a OCHSNER MEDICAL CENTER   (United States)

^b OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

CAD; CMV; Coronary artery disease; Cytomegalovirus; EBD; Explosive brain death; HLA; Human leukocyte antigen; International Society for Heart and Lung Transplantation; ISHLT; JNC; Joint National Commission

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE;

ADULT; ARTICLE; BRAIN DEATH; CARDIAC ALLOGRAFT VASCULOPATHY; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY; DISEASE ASSOCIATION; EVALUATION; FEMALE; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HEART TRANSPLANTATION; HUMAN; INTRACRANIAL PRESSURE; INTRAVASCULAR ULTRASOUND; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SUDDEN DEATH; VASCULAR DISEASE;

ADULT; AGED; BRAIN DEATH; CAUSE OF DEATH; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; FEMALE; HEART TRANSPLANTATION; HUMANS; INCIDENCE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 1542271688     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2003.08.059     Document Type: Article

References (21)

1. Novitzky D., Rhodin J., Cooper D.K., Ye Y., Min K.W., DeBault L. Ultrastructure changes associated with brain death in the human donor heart. Transpl Int. 10:1997;24-32.
2. Segel L.D., vonHaag D.W., Zhang J., Follette D.M. Selective overexpression of inflammatory molecules in hearts from brain-dead rats. J Heart Lung Transplant. 21:2002;804-811.
3. Shivalkar B., Van Loon J., Wieland W., et al. Variable effects of explosive or non-explosive increase of intracranial pressure on myocardial structure and function. Circulation. 87:1993;230-239.
4. Mehra M.R. Crossing the vasculopathy bridge from morphology to therapy A single center experience. J Heart Lung Transplant. 19:2000;522-528.
5. Rickenbacher P.R., Pinto F.J., Lewis N.P., et al. Prognostic importance of intimal thickness as measured by intracoronary ultrasound after cardiac transplantation. Circulation. 92:1995;3445-3452.
6. Labarrere C.A., Pitts D., Nelson D.R., Faulk W.P. Vascular tissue plasminogen activator and the development of coronary artery disease in heart-transplant recipients. N Engl J Med. 333:1995;1111-1116.
7. Labarrere C.A., Nelson D.R., Cox C.J., et al. Cardiac-specific troponin I levels and risk of coronary artery disease and graft failure following heart transplantation. JAMA. 284:2000;457-464.
8. Mehra M.R., Ventura H.O., Chambers R., et al. Predictive model to assess risk for cardiac allograft vasculopathy An intravascular ultrasound study. J Am Coll Cardiol. 26:1995;1537-1544.
9. St. Goar F.G., Pinto F.J., Alderman E.L., et al. Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening. Circulation. 85:1992;979-987.
10. Mehra M.R., Ventura H.O., Stapleton D.D., et al. Presence of severe intimal thickening by intravascular ultrasonography predicts cardiac events in cardiac allograft vasculopathy. J Heart Lung Transplant. 14:1995;632-639.
11. 3), activation of the matrix metalloproteinase induction system, and subsequent development of coronary vasculopathy. Circulation. 105:2002;1955-1961.
12. Pethig K, Heublein B, Kutschka, Haverich A. Systemic inflammatory response in cardiac allograft vasculopathy: high sensitivity C-reactive protein is associated with progressive luminal obstruction. Circulation 2000;102 Suppl III:233-6.
13. Anyanwu A.C., Banner N.R., Mitchell A.G., Khaghani A., Yacoub M.H. Low incidence and severity of transplant-associated coronary artery disease in heart transplants from live donors. J Heart Lung Transplant. 22:2003;281-286.
14. Novitzky D., Rose A.G., Cooper D.K. Injury of myocardial conduction tissue and coronary artery smooth muscle following brain death in the baboon. Transplantation. 45:1988;964-966.
15. Takada M., Nadeau K.C., Hancock W.W., et al. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation. 65:1998;1533-1542.
16. Szabo G., Hackert T., Buhmann V., Sebening C., Vahl C.F., Hagl S. Myocardial performance after brain death Studies in isolated hearts. Ann Transplant. 5:2000;45-50.
17. Szabo G., Buhmann V., Bahrle S., Vahl C.F., Hagl S. Brain death impairs coronary endothelial function. Transplantation. 73:2002;1846-1848.
18. Birks E.J., Yacoub M.H., Burton P.S., et al. Activation of apoptotic and inflammatory pathways in dysfunctional donor hearts. Transplantation. 70:2000;1498-1506.
19. Tsai F.C., Marelli D., Bresson J., et al. UCLA Heart Transplant Group. Use of hearts transplanted from donors with atraumatic intracranial bleeds. J Heart Lung Transplant. 21:2002;623-628.
20. Yamani MH, Starling RC, Tuzcu EM, et al. Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: evidence from intravascular ultrasound (abstr). J Heart Lung Transplant 2003;22:S76.
21. Mehra M.R., Ventura H.O., Chambers R.B., Ramireddy K., Smart F.W., Stapleton D.D. The prognostic impact of immunosuppression and cellular rejection on cardiac allograft vasculopathy: time for a reappraisal. J Heart Lung Transplant. 16:1997;743-751.