The paediatric cytarabine syndrome can be viewed as a drug-induced cytokine release syndrome

British Journal of Haematology

Volumn 124, Issue 5, 2004, Pages 691-

  Ek, Torben ^a   Abrahamsson, Jonas ^a  

^a QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

Author keywords

Cytarabine induced fever; Cytokines; Interferon ; Interleukin 6; Tumour necrosis factor

Indexed keywords

C REACTIVE PROTEIN; CYTARABINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL PAIN; ADOLESCENT; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTARABINE SYNDROME; CYTOKINE RELEASE; DATA ANALYSIS; DRUG INDUCED DISEASE; DRUG MEGADOSE; EVALUATION; FEVER; HUMAN; INFUSION; LABORATORY TEST; LETTER; MALAISE; MYALGIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; RASH; REMISSION; SIDE EFFECT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADOLESCENT; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; CYTARABINE; CYTOKINES; FEVER; HUMANS; INFANT; SYNDROME;

EID: 1542269658     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.04822.x     Document Type: Letter

References (3)

1. Andersson, B.S., Luna, M.A., Yee, C., Hui, K.K., Keating, M.J. & McCredie, K.B. (1990) Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia. Cancer, 65, 1079-1084.
2. Chng, W.J. (2003) Cytarabine syndrome revisited. British Journal of Haematology, 122, 875.
3. Ek, T., Jarfelt, M., Mellander, L. & Abrahamsson, J. (2001) Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children. Medical and Pediatric Oncology, 37, 459-464.