LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space

Clinical and Experimental Immunology

Volumn 135, Issue 3, 2004, Pages 519-527

  Pace, E ^a   Profita, M ^a   Melis, M ^a   Bonanno, A ^a   Paterno A ^b   Mody, C H ^c   Spatafora, M ^b   Ferraro, M ^a   Siena, L ^a   Vignola, A M ^a,b   Bonsignore, G ^a   Gjomarkaj, M ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

LTB4; Neutrophils; Pleura

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; LEUKOCYTE ELASTASE; LEUKOTRIENE; LEUKOTRIENE B4; MESSENGER RNA; LIPOPOLYSACCHARIDE; PANCREATIC ELASTASE;

ADULT; AGED; ARTICLE; CANCER; CANCER CELL; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LOBAR PNEUMONIA; LUNG TUBERCULOSIS; LYMPHOCYTE; MACROPHAGE; MESOTHELIUM CELL; NEUTROPHIL; PLEURA CAVITY; PLEURA EFFUSION; PLEURA FLUID; PRIORITY JOURNAL; BIOSYNTHESIS; ENZYMOLOGY; EPITHELIUM; GENE EXPRESSION; GENETICS; HEAT; IMMUNOLOGY; MACROPHAGE ACTIVATION; METABOLISM; MIDDLE AGED; NEOPLASM; NEUTROPHIL CHEMOTAXIS; PNEUMONIA;

ADULT; AGED; ARACHIDONATE 5-LIPOXYGENASE; CHEMOTAXIS, LEUKOCYTE; EPITHELIUM; GENE EXPRESSION; HEAT; HUMANS; LEUKOTRIENE B4; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MIDDLE AGED; NEOPLASMS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PANCREATIC ELASTASE; PLEURAL EFFUSION; PNEUMONIA; RNA, MESSENGER; TUBERCULOSIS, PULMONARY;

EID: 1542269348     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2003.02387.x     Document Type: Article

References (31)

1. Kroegel C, Antony VB. Immunobiology of pleural inflammation: potential implications for pathogenesis, diagnosis and therapy. Eur Respir J 1997; 10:2411-8.
2. Antony VB, Godbey SW, Kunkel SL et al. Recruitment of inflammatory cells to the pleural space. Chemotactic cytokines, IL-8, and monocyte chemotactic peptide-1 in human pleural fluids. J Immunol 1993; 151:7216-23.
3. Pace E, Gjomarkaj M, Melis M et al. Interleukin-8 induces lymphocytes chemotaxis into the pleural space: role of pleural macrophages. Am J Respir Crit Care Med 1999; 159:1592-9.
4. Courtney Broaddus V, Hebert CA, Vitangcol RV, Hoeffel JM, Bernstein V, Boylan AM. Interleukin-8 is a major neutrophil chemotactic factor in pleural liquid of patients with empyema. Am Rev Respir Dis 1992; 146:825-30.
5. Miller EJ, Idell S. Interleukin-8: an important neutrophil chemotaxin in some cases of exudative pleural effusions. Exp Lung Res 1993; 19:589-601.
6. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH. Leukotriene B. a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980; 286:264-5.
7. Borgeat P, Naccache PH. Biosynthesis and biological activity of leukotriene B4. Clin Biochem 1990; 23:459-68.
8. Rankin JA, Sylvester I, Smith S, Yoshimura T, Leonard EJ. Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/ activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan. J Clin Invest 1990; 86:1556-64.
9. Aoki Y, Qiu D, Zhao GH, Kao PN. Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells. Am J Physiol 1998; 274:1030-9.
10. Nourshargh S. Mechanisms of neutrophil and eosinophil accumulation in vivo. Am Rev Respir Dis 1993; 148 (Suppl.):S60-S64.
11. Light RW, Erozan YS, Ball CW. Cells in the pleural fluid. Their value in differential diagnosis. Arch Intern Med 1973; 132:854-60.
12. Queiroz C, Barral-Netto M, Bacchi CE. Characterizing subpopulations of neoplastic cells in serous effusions. The role of immunocytochemistry. Acta Cytol 2001; 45:18-22.
13. Comin CE, Novelli L, Boddi V, Paglierani M, Dini S. Calretinina, Thrombomodulin, CEA, and CD15: a useful combination of immunohistochemical markers for differentiate pleural epithelial mesothelioma from pulmonary adenocarcinoma. Hum Pathol 2001; 32:529-36.
14. Cruikshank WW, Long A, Tarpy RE et al. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics. Am J Respir Cell Mol Biol 1995; 13:738-47.
15. Bellia V, Bonanno A, Cibella F et al. Urinary leukotriene E4 in the assessment of nocturnal asthma. J Allergy Clin Immunol 1996; 97:735-41.
16. Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA. Cloning of the cDNA for human 5-lipoxygenase. Proc Natl Acad Sci USA 1988; 85:416-20.
17. Gjomarkaj M, Pace E, Melis M et al. Phenotypic and functional characterization of normal rat pleural macrophages in comparison with autologous peritoneal and alveolar macrophages. Am J Resp Cell Mol Biol 1999; 20:135-42.
18. Veena BA, Hott JW, Kunkel SL, Godbey SW, Burdick MD, Strieter RM. Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin 8) chemokines. Am J Respir Cell Mol Biol 1995; 12:581-8.
19. Doring G. The role of neutrophil elastase in chronic inflammation. Am J Respir Crit Care Medical 1994; 150:8114-5117.
20. Segura RM, Alegre J, Varela E et al. Interleukin-8 and markers of neutrophil degranulation in pleural effusions. Am J Respir Crit Care Med 1998; 157:1565-72.
21. Lukacs NW, Strieter RM, Kunkel SL. Leukocyte infiltration in allergic airway inflammation. Am J Respir Cell Mol Biol 1995; 13:1-6.
22. Koyama S, Sato E, Masubuchi T et al. Human lung fibroblasts release chemokinetic activity for monocytes constitutively. Am J Physiol 1998; 275:L223-L230.
23. Hommes DW, Meenan J, de Haas M et al. Soluble Fc gamma receptor III (CD 16) and eicosanoid concentrations in gut lavage fluid from patients with inflammatory bowel disease: reflection of mucosal inflammation. Gut 1996; 38:564-7.
24. Klosterhalfen B, Peters KM, Tons C, Hauptmann S, Klein CL, Kirkpatrick CJ. Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. J Trauma 1996; 40:372-8.
25. Mikami M, Llewellyn JC, Bayley D, Hill SL, Stockley RA. The chemotactic activity of sputum from patients with bronchiectasis. Am J Respir Crit Care Med 1998; 157:723-8.
26. Sampson AP, Spencer DA, Green CP, Piper PJ, Price JF. Leukotrienes in the sputum and urine of cystic fibrosis children. Br J Clin Pharmacol 1990; 30:861-9.
27. Abe M, Matsuki H, Domae M et al. Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2. Am J Respir Cell Mol Biol 1996; 15:565-73.
28. Nasreen N, Mohammed KA, Sanders KL et al. Pleural mesothelial cells modulate polymorphonuclear leukocyte apoptosis in empyema. J Clin Immunol 2003; 23:1-10.
29. McCain RW, Holden EP, Blackwell TR, Christman JW. Leukotriene B4 stimulates human polymorphonuclear leukocytes to synthesize and release interleukin-8 in vitro. Am J Respir Cell Mol Biol 1994; 10:651-7.
30. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000; 192:421-31.
31. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARa-leukotriene B4 pathway to inflammation control. Nature 1996; 384:39-43.