The solution structure of the N-terminal domain of E3L shows a tyrosine confirmation that may explain its reduce affinity to Z-DNA in vitro

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 2712-2717

  Kahmann, Jan D ^a   Wecking, Diana A ^a   Putter, Vera ^a   Lowenhaupt, K ^c   Kim, Yang Gyun ^c,d   Schmieder, Peter ^b   Oschkinat, Hartmut ^b   Rich, Alexander ^c   Schade, Markus ^a  

^a MerLion Pharmaceuticals GmbH   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; DNA Z; NITROGEN 15; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN E3L;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DNA BINDING; DNA VIRUS; ISOTOPE LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POXVIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; VACCINIA VIRUS; VIRUS GENE; VIRUS GENE E3L; VIRUS PATHOGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; DNA, Z-FORM; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RNA-BINDING PROTEINS; SOLUTIONS; TYROSINE; VIRAL PROTEINS;

DNA VIRUSES; POXVIRIDAE; VACCINIA; VACCINIA VIRUS;

EID: 1542267839     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308612100     Document Type: Article

References (17)

1. Cohen, J. (2001) Science 294, 985.
2. Brandt, T. A. & Jacobs, B. L. (2001) J. Virol. 75, 850-856.
3. Kim, Y. G., Lowenhaupt, K., Oh, D. B., Kim, K. K. & Rich, A. (2004) Proc. Natl. Acad. Sci. USA, in press.
4. Kim, Y. G., Muralinath, M., Brandt, T., Pearcy, M., Hauns, K., Lowenhaupt, K., Jacobs, B. L. & Rich, A. (2003) Proc. Natl. Acad. Sci. USA 100, 6974-6979.
5. Schade, M., Turner, C. J., Lowenhaupt, K., Rich, A. & Herbert, A. (1999) EMBO J. 18, 470-479.
6. Schade, M., Behlke, J., Lowenhaupt, K., Herbert, A., Rich, A. & Oschkinat, H. (1999) FEBS Lett. 458, 27-31.
7. Schwartz, T., Rould, M. A., Lowenhaupt, K., Herbert, A. & Rich, A. (1999) Science 284, 1841-1845.
8. Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U. & Rich, A. (2001) Nat. Struct. Biol. 8, 761-765.
9. Schade, M., Turner, C. J., Kuhne, R., Schmieder, P., Lowenhaupt, K., Herbert, A., Rich, A. & Oschkinat, H. (1999) Proc. Natl. Acad. Sci. USA 96, 12465-12470.
10. Cavanagh, J., Fairbrother, W. J., Palmer, A. G. & Skelton, N. J. (1996) Protein NMR Spectroscopy (Academic, San Diego).
11. Goddard, T. D. & Kneller, D. G. (2002) SPARKY 3 (University of California, San Francisco).
12. Markley, J. L., Bax, A., Arata, Y., Hilbers, C. W., Kaptein, R., Sykes, B. D., Wright, P. E. & Wuthrich, K. (1998) J. Mol. Biol. 280, 933-952.
13. Shuker, S. B., Hajduk, P. J., Meadows, R. P. & Fesik, S. W. (1996) Science 274, 1531-1534.
14. Guntert, P., Mumenthaler, C. & Wuthrich, K. (1997) J. Mol. Biol. 273,283-298.
15. Spera, S., Ikura, M. & Bax, A. (1991) J. Biomol. NMR 1, 155-165.
16. Cornilescu, G., Delaglio, F. & Bax, A. (1999) J. Biomol. NMR 13, 289-302.
17. Behe, M. & Felsenfeld, G. (1981) Proc. Natl. Acad. Sci. USA 78, 1619-1623.