The prognostic value of pathological and molecular margins marked by p53 and el4E in laryngeal carcinoma

Chinese-German Journal of Clinical Oncology

Volumn 4, Issue 1, 2005, Pages 56-60

  Xia, Liangping ^a   Zeng, Jian ^b   Guo, Zhuming ^a   Rao, Huilan ^a   Zeng, Jing ^a   Zeng, Zongyuan ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b Guangzhou Tumor Hospital   (China)

Author keywords

Eukaryotic translation initiation factor 4E; Laryngeal neoplasm squamous cell carcinoma; Molecular margin; P53; Prognosis

Indexed keywords

BIOCHEMICAL MARKER; INITIATION FACTOR 4E; MONOCLONAL ANTIBODY; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNGECTOMY; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; NECK DISSECTION; PATHOPHYSIOLOGY; PROGNOSIS; PROTEIN EXPRESSION; RECURRENCE RISK;

EID: 15344350868     PISSN: 16101979     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10330-004-0241-0     Document Type: Article

References (22)

1. Snijder RJ, Brutel de la Riviere A, Elbers HJ, et al. Survival in resected stage I lung cancer with residual tumor at the bronchial resection margin. Ann Thorac Surg, 1998, 65: 212-216.
2. Higashiyama M, Kodama K, Yokouchi H, et al. A novel test of the surgical margin in patients with lung cancer undergoing limited surgery: lavage cytologic technique. J Thorac Cardiovasc Surg, 2000, 120: 412-413.
3. Law S, Arcilla C, Chu KM, et al. The significance of histologically infiltrated resection margin after esophagectomy for esophageal cancer. Am J Surg, 1998, 176: 286-290.
4. Casson AG, Darnton SJ, Subramanian S, et al. What is the optimal distal resection margin for esophageal carcinoma? Ann Thorac Surg, 2000, 69: 205-209.
5. Cianchi F, Messerini L, Palomba A, et al. Character of the invasive margin in colorectal cancer: Does it improve prognostic information of Dukes staging? Dis Colon Rectum, 1997, 40: 1170-1176.
6. Peiffert D, Bey P, Pernot M, et al. Conservative treatment by irradiation of epidermoid carcinomas of the anal margin. Int J Radiat Oncol Biol Phys, 1997, 39: 57-66.
7. Peterson ME, Schultz DJ, Reynolds C, et al. Outcomes in breast cancer patients relative to margin status after treatment with breast-conserving surgery and radiation therapy: The University of Pennsylvania experience. Int J Radiat Oncol Biol Phys, 1999, 43: 1029-1035.
8. Luu HH, Otis CN, Reed WP Jr, et al. The unsatisfactory margin in breast cancer surgery. Am J Surg, 1999, 178: 362-366.
9. Jacobs JR, Ahmad K, Casiano R, et al. Implications of positive surgical margins. Laryngoscope, 1993, 103: 64-68.
10. Solano J, Esteban F, Delgado M, et al. Histopathological malignancy and prognosis of laryngeal cancer. Acta Otorrinolaringol Esp, 1997, 48: 375-382.
11. Zeng Z, Xia L, Chen F, et al. Value of surgical margin in directing the treatment of early laryngeal carcinoma after partial laryngectomy. Chin J Otorhinolarygol (Chinese), 2001, 36: 250-253.
12. Xu GP, Zeng ZY, Xia LP, et al. Surgical margin to direct the treatment and predict the prognosis of laryngeal carcinoma after partial laryngectomy. Cancer (Chinese), 2002, 21: 200-203.
13. Nees M, Homann N, Discher H, et al. Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: A possible molecular basis for the development of multiple tumors. Cancer Res, 1993, 53: 4189-4196.
14. Wan B, Dong M, Ma J, et al. Immunohistochemical study of safe resection margin in the surgical treatrent of laryngeal carcinoma. J Clin Otolaryngol (Chinese), 1999, 13: 394-396.
15. Wei B, Tang P, Tu G. The status of protein p16 and p53 in the surgical margins of laryngeal carcinoma and the associction with local recurrence. Chin J Otorhinolarygol (Chinese), 2000, 35: 461-463.
16. Maestro R, Dolcetti R, Gasparotto D, et al. High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene, 1992, 7: 1159-1166.
17. Field JK, Spandidos DA, Malliri A, et al. Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck. Br J Cancer, 1991, 64: 573-577.
18. Nathan CA, Sanders K, Abreo FW, et al. Correlation of p53 and the proto-oncogene eIF4E in larynx cancers: Prognostic implications. Cancer Res, 2000, 60: 3599-3604.
19. Franklin S, Pho T, Abreo FW, et al. Detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers. Arch Otolaryngol Head Neck Surg, 1999, 125: 177-182.
20. Nathan CA, Liu L, Li BD, et al. Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene, 1997, 15: 579-584.
21. Xia LP, Zeng ZY, Wei MW, et al. The univariate and multivariate analysis of the factors affecting the survival rate of laryngeal carcinoma. Bull Chin Cancer, 2002, 11: 655-657.
22. Bauer WC, Lesinski SG, Ogura JH. The significance of positive margins in hemilaryngectomy specimens. Laryngoscope, 1975, 85: 1-13.