Myocardial injury occurs earlier than myocardial inflammation in acute experimental viral myocarditis

Experimental and Molecular Medicine

Volumn 37, Issue 1, 2005, Pages 51-57

  Lim, Byung Kwan ^a   Shin, Jae Ok ^a   Choe, Seong Choon ^b   Choi, Si Wan ^c   Jeong, Jin Ok ^c   Seong, In Whan ^c   Kim, Duk Kyung ^a   Jeon, Eun Seok ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Sanofi Synthelabo Korea ^*  (South Korea)

^c Chungnam National University College of Medicine   (South Korea)

Author keywords

Inflammation; Mocardial injury; Toponin; Viral myocarditis

Indexed keywords

TROPONIN T;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART MUSCLE BIOPSY; HEART MUSCLE INJURY; MOUSE; NONHUMAN; VIRUS MYOCARDITIS;

EID: 15344346903     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2005.7     Document Type: Article

References (21)

1. Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ Jr, Olsen EG, Schoen FJ. Myocarditis: A histopathologic definition and classification. Am J Cardiovasc Pathol 1987;1:3-14
2. Bachmaier K, Mair J, Offner F, Pummerer C, Neu N. Serum cardiac troponin T and creatine kinase-MB elevations in murine autoimmune myocarditis. Circulation 1995;92:1927-32
3. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU. Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med 1999;5:320-6
4. Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000; 343:1388-98
5. Fowles RE, Mason JW. Role of cardiac biopsy in the diagnosis and management of cardiac disease. Prog Cardiovasc Dis 1984;27:153-72
6. Hamm CW, Ravkilde J, Gerhardt W, Jorgensen P, Peheim E, Ljungdahl L, Goldmann B, Katus HA. The prognostic value of serum troponin T in unstable angina. N Engl J Med 1992;327:146-50
7. Jung HW, La SJ, Kim JY, Heo SK, Kim JY, Wang S, Kim KK, Lee KM, Cho HR, Lee HW, Kwon B, Kim BS, Kwon BS. High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases. Exp Mol Med 2003;35:501-8
8. Jung HW, Choi SW, Choi JI, Kwon BS. Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 2004; 36:13-22
9. Kawai C. From myocarditis to cardiomyopathy: Mechanism of inflammation and cell death: learning from the past for the future. Circulation 1999;99:1091-100
10. Katus HA, Looser S, Hallermayer K, Remppis A, Scheffold T, Borgya A, Essig U, Geuss U. Development and in vitro characterization of a new immunoassay of cardiac troponin T. Clin Chem 1992;38:386-93
11. Knowlton KU, Jeon ES, Berkley N, Wessely R, Huber SA. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol 1996;70:7811-8
12. Knowlton KU, Badorff C. The immune system in viral myocarditis: maintaining the balance. Circ Res 1999;85:559-61
13. Lauer B, Niederau C, Kuhl U, Schannwell M, Pauschinger M, Strauer BE, Schultheiss HP. Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 1997;30:1354-9
14. Li Y, Bourlet T, Andreoletti L, Mosnier JF, Peng T, Yang Y, Archard LC, Pozzetto B, Zhang H. Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulaton 2000;101:231-4
15. Mason JW, O'Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, Moon TE. A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med 1995; 333:269-75
16. McCarthy RE 3rd, Boehmer JP, Hruban RH, Hutchins GM, Kasper EK, Hare JM, Baughman KL. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N Engl J Med 2000;342:690-5
17. Parrillo JE, Aretz HT, Palacios I, Fallon JT, Block PC. The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure. Circulation 1984;69:93-101
18. Seong IW, Choe SC, Jeon ES. Fulminant coxsackieviral myocarditis. N Engl J Med 2001;345:379
19. Smith SC, Laden JH, Mason JW, Jaffe AS. Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Circulation 1997;95:163-8
20. Straub V, Rafael JA, Chamberlain JS, Campbell KP. Animal models for muscular dystrophy show different patterns of sarcolemmal disruption. J Cell Biol 1997;139:375-85
21. Van Houten N, Bouchard PE, Moraska A, Huber SA. Selection of an attenuated coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen. J Virol 1991;65:1286-90