Unexpected formation of etheno-2′-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: Evidence for a bis-hydroperoxide intermediate

Chemical Research in Toxicology

Volumn 18, Issue 3, 2005, Pages 599-610

  Jian, Wenying ^a   Lee, Seon Hwa ^a   Arora, Jasbir S ^a   Elipe, Maria V Silva ^b   Blair, Ian A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,N2 ETHENO 2' DEOXYGUANOSINE; 3 (2' DEOXY BETA DEXTRO ERYTHROPENTAFURANOSYL)IMIDAZO 7 (5''CARBOXYPENTA 2'' ONE) 9 OXO[1,2 A]PURINE; 4 HYDROPEROXY 2 NONENAL; 4 OXO 2 NONENAL; 5 CARBOXY 2 PENTANONE 1,N2 ETHENO 2' DEOXYGUANOSINE; 5,8 DIOXOOCTENOIC ACID; 6 CARBOXY 3 HYDROXY 1 HEXENE 1,N2 ETHENO 2' DEOXYGUANOSINE; ARACHIDONATE 5 LIPOXYGENASE; ASCORBIC ACID; CARBOXYLIC ACID DERIVATIVE; DEOXYGUANOSINE; ETHENO 2' DEOXYGUANOSINE; FERRIC ION; FERROUS ION; HYDROPEROXIDE DERIVATIVE; HYDROPEROXY 6,8,11,14 EICOSATETRAENOIC ACID; HYDROPEROXYICOSATETRAENOIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; DNA ADDUCT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PEROXIDATION; REACTION ANALYSIS;

DEOXYGUANOSINE; DNA ADDUCTS; LEUKOTRIENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 15344343865     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049693d     Document Type: Article

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