Effect of early phase adjuvant arthritis on hepatic P450 enzymes and pharmacokinetics of verapamil: An alternative approach to the use of an animal model of inflammation for pharmacokinetic studies

Drug Metabolism and Disposition

Volumn 33, Issue 4, 2005, Pages 579-586

  Ling, Spencer ^a   Jamali, Fakhreddin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 3A; LIVER ENZYME; NITRITE; TUMOR NECROSIS FACTOR ALPHA; VERAPAMIL;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATION; MALE; MYCOBACTERIUM BUTYRICUM; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RAT STRAIN;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOOD PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; INFLAMMATION; INJECTIONS, INTRAVENOUS; MALE; MICROSOMES, LIVER; MYCOBACTERIUM; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; VERAPAMIL;

ANIMALIA; MYCOBACTERIUM BUTYRICUM;

EID: 15344338966     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.002360     Document Type: Article

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