Salbutamol pMDI gives less protection to methacholine induced airway obstruction than salbutamol via spacer or DPI

European Journal of Clinical Pharmacology

Volumn 60, Issue 12, 2005, Pages 837-841

  Broeders, Mariëlle E A C ^a   Molema, Johan ^a   Hop, Wim C J ^b   Folgering, Hans T M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Inhalation therapy; Methacholine challenge test; Salbutamol

Indexed keywords

METHACHOLINE; SALBUTAMOL;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DRUG EFFECT; DRUG EFFICACY; DRY POWDER; DYSPNEA; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INSPIRATORY CAPACITY; LUNG FUNCTION; MALE; METERED DOSE INHALER; OPEN STUDY; PEAK EXPIRATORY FLOW; POWDER INHALER; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ALBUTEROL; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; BRONCHODILATOR AGENTS; FEMALE; HUMANS; MALE; METERED DOSE INHALERS; METHACHOLINE CHLORIDE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS;

EID: 15244363483     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0844-y     Document Type: Article

References (11)

1. Waldeck B (2002) beta-Adrenoceptor agonists and asthma-100 years of development. Eur J Pharmacol 445(1-2):1-12
2. Ganderton D (1997) General factors influencing drug delivery to the lung. Respir Med 91(Suppl A):13-16
3. Selroos O, Pietinhalho A, Riska H (1996) Delivery devices for inhaled asthma medication. Clinical implications of differences in effectiveness. Clin Immunother 6(4):273-299
4. Prime D, Grant AC, Slater AL et al (1999) A critical comparison of the dose delivery characteristics of four alternative inhalation devices delivering salbutamol: pressurized metered dose inhaler, Diskus inhaler, Diskhaler inhaler, and Turbuhaler inhaler. J Aerosol Med 12:75-84
5. Smith KJ, Chan H-K, Brown KF (1998) Influence of flow rate on aerosol particle size distributions from pressurized and breath-actuated inhalers. J Aerosol Med 11(4):231-245
6. Juniper E, Cockcroft D, Hargreave F (1999) Histamine and methacholine inhalation tests: tidal breathing method, laboratory procedure and standardisation. Canadian Thoracic Society, Sweden, AB Draco, Lund
7. Bisgaard H, Klug B, Sumby BS et al (1998) Fine particle mass from the Diskus inhaler and Turbuhaler inhaler in children with asthma. Eur Respir J 11(5):1111-1115
8. Derom E, Borgstrom L, Van Schoor J et al (2001) Lung deposition and protective effect of terbutaline delivered from pressurized metered-dose inhalers and the turbuhaler in asthmatic individuals. Am J Respir Crit Care Med 164(8):1398-1402
9. Giannini D, Di Franco A, Bacci E et al (2000) The protective effect of salbutamol inhaled using different devices on methacholine bronchoconstriction. Chest 117:1319-1322
10. Berne RM, Levy MN (1998) Physiology, 4th edn. St. Louis, USA
11. Taube C, Lehnigk B, Paasch K et al (2000) Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 162(1):216-220