Synthesis and anti-inflammatory activity of 1-acylaminoalkyl-3,4- dialkoxybenzene derivatives

Farmaco

Volumn 60, Issue 3, 2005, Pages 203-207

  Labanauskas, L ^a   Brukstus, A ^a   Udrenaite, E ^a   Bucinskaite, V ^a   Susvilo, I ^a   Urbelis, G ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

Author keywords

1 Acylaminoalkyl 3,4 dialkoxybenzene derivatives; Anti inflammatory activity; N acylation

Indexed keywords

1 (2 BENZYL 4,5 DIMETHOXYPHENYL)ETHYLAMINE; 1 (2 BROMO 4,5 DIETHOXYPHENYL)ETHYLAMINE; 1 (2 BROMO 4,5 DIMETHOXYPHENYL) 1 ETHANONE; 1 (2 BROMO 4,5 DIMETHOXYPHENYL)ETHYLAMINE; 1 (2 CHLORO 4,5 DIETHOXYPHENYL)ETHYLAMINE; 1 (2 CHLORO 4,5 DIMETHOXYPHENYL) 1 ETHANONE; 1 (2 CHLORO 4,5 DIMETHOXYPHENYL)ETHYLAMINE; 1 (2 ETHYL 4,5 DIMETHOXYPHENYL) 1 ETHANONE; 1 (2 ETHYL 4,5 DIMETHOXYPHENYL)ETHYLAMINE; 1 (7 ETHYL 2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL) 1 ETHANONE; 1 (7 ETHYL 2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL)ETHYLAMINE; ALKOXYBENZENE DERIVATIVE; ANTIINFLAMMATORY AGENT; BENTONITE; CARRAGEENAN; CHLORINE DERIVATIVE; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ACYLATION; AMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AROMATIZATION; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG SAFETY; DRUG SYNTHESIS; LD 50; LETHAL DOSE; MALE; NONHUMAN; PAW EDEMA; PREDICTION; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 15244355254     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2004.12.003     Document Type: Article

References (13)

1. P. Gaidelis, V. Dauksas, E. Udrenaite, and L. Labanauskas Synthesis and anti-inflammatory properties of 8-(3-dimethylamino-propionyl)-1,6-benzodioxokane Arzneim.-Forsch./Drug Res. 45 (II) 11 1995 1202 1206
2. L. Labanauskas, A. Brukstus, V. Kalcas, E. Udrenaite, P. Gaidelis, and V. Dauksas Synthesis of 3-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-5-thiol and 2-amino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole derivatives exhibiting anti-inflammatory activity Pharmazie 56 8 2001 617 619
3. L. Labanauskas, A. Brukstus, Gaidelis, V. Dauksas, and E. Udrenaite Synthesis and anti-inflammatory activity of new 6-benzoyl-1,4-benzodioxane derivatives Pharm. Chem. J. 33 5 1999 33 34 (rus)
4. Yu.V. Borodina, D.A. Filimonov, and V.V. Poroikov Computer-aided prediction of prodrug activity using the PASS system Pharm. Chem. J. (rus) 30 1 1996 39 42
5. P. Gaidelis, V. Dauksas, E. Udrenaite, and V. Kuliesius Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-dimethylaminopropionyl)benzene and their 5-halogeno derivatives Arzneim.-Forsch./Drug Res. 44 (II) 7 1994 835 839
6. J. Shinoda, and S. Sato Synthesis of 3,4-dimethoxy-6-ethylbenzoic acid J. Pharm. Soc. Jap. 548 1927 860 863 (CA, 22 (1928) 772)
7. V. Dauksas, E. Udrenaite, and R. Martinkus Synthesis and properties of 6,7-diethyl-5-acetyl-1,4-benzodioxan Liet. TSR Aukst. Mokyklu Mokslo Darb., Chem. Chem. Technol. 16 1974 181 185 (CA 83 (1975) 206184k)
8. C.A. Winter, E.A. Risley, and G.W. Nuss Carrageenin-induced oedema in hind paw of rat as the assay for antiinflammatory drugs Proc. Soc. Exp. Biol.(N.Y.) 3 1962 544 547
9. J. Marek Bentonite-induced rat oedema as a tool for simultaneous testing of prophylactic and therapeutic effects of anti-inflammatory and other drugs Pharmazie 1981 46 49
10. J.T. Litchfield, and F.J. Wilkoxon A simplified method of evaluating dose-effect experiments Pharmacol. Exp. Ther. 96 1949 99 105
11. V. Poroikov, D. Filimonov. Computer-aided prediction of biological activity spectra. Application for finding and optimization of new leads, in: Rational Approaches to Drug Design. H.-D. Holtje, W. Sippl (Eds). Prous Science, Barcelona. (2001) pp. 403-407
12. D.A. Filimonov, and V.V. Poroikov PASS: Computerized prediction of biological activity spectra for chemical substances. Bioactive Compound Design: Possibilities for Industrial Use 1996 BIOS Scientific Publishers Oxford 47 56
13. http://www.ibmh.msk.su/PASS/Ref.html.