Investigation of the hypothalamopituitary-adrenal axis by low-dose (1 μg) adrenocorticotrophic hormone test and metyrapone test in patients with chronic fatigue syndrome

Endocrinologist

Volumn 15, Issue 2, 2005, Pages 89-92

  Izgi, H B ^a   Gokce C ^a   Calis M ^a   Turan, T ^a   Kirnap, M ^a   Sofuoglu S ^a   Durak, A C ^a   Tutus A ^a   Kelestimur F ^a,b  

^a Department of Psychiatrics ^*  (Turkey)

^b ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

CFS; HPA axis; Low dose ACTH test; Metyrapone test

Indexed keywords

CORTICOTROPIN; CORTODOXONE; HYDROCORTISONE; METYRAPONE;

ADRENAL GLAND; ADULT; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DISEASE DURATION; DIZZINESS; FEMALE; HORMONE ACTION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; MALE; PROVOCATION TEST; SIDE EFFECT; THICKNESS;

EID: 15244350171     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ten.0000157885.71463.43     Document Type: Article

References (27)

1. Fukuda K, Straus SE, Hickie I, et al. The Chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121:953-959.
2. Buchwald D, Umali P, Umali J, et al. Chronic fatigue and chronic fatigue syndrome: prevalence in a Pacific Northwest health care system. Ann Intern Med. 1995;123:81-88.
3. Wessely S. The epidemiology of chronic fatigue syndrome. Epidemiol Rev. 1995;17:139-151.
4. Neeck G, Crafford LJ. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am. 2000;26:989-1002.
5. Demitrack M, Dale J, Laue L, et al. Evidence for impaired activation of the hypothalamic-pituitary- adrenal axis in chronic fatigue syndrome. J Clin Endocrinol Metab. 1991;72:773-778.
6. Parker ASR, Wessely S, Cleare AJ, et al. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med. 2001;31:1331-1345.
7. Dickstein G, Spigel D, Arad E, et al. One microgram is the lowest ACTH dose to cause maximal cortisol response. There is no diurnal variation of cortisol response to submaximal ACTH stimulation. Eur J Endocrinol. 1997;137:172-175.
8. Dökmetaş HS, Çolak R, Keleştimur F, et al. A comparison between the 1-μg adrenocorticotropin (ACTH) test, the short ACTH (250 μg) test, and the insulin tolerance test in assessment of hypothalamo-pituitary-adrenal axis immediately after pituitary surgery. J Clin Endocrinol Metab. 2000;85:3713-3719.
9. Rasmuson S, Olsson T, Hagg E. A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol. 1997;44:151-156.
10. Kirnap M, Çolak R, Eser C, et al. A comparison between low-dose (1 μg), standard-dose (250 μg) ACTH stimulation tests and insulin tolerance test in the evaluation of the hypothalamo-pituitary-adrenal axis in primary fibromyalgia syndrome. Clin Endocrinol. 2001;55:455-459.
11. Steiner H, Bahr V, Exner P, et al. Pituitary function tests: comparison of ACTH and 11-deoxy-cortisol responses in the metyrapone test with the insulin hypoglycemia test. Exp Clin Endocrinol. 1994;102:33-38.
12. Fiad TM, Kirby JM, Cunningham SK, et al. The overnight single-dose metyrapone test is a simple and reliable index of the hypothalamic-pituitary- adrenal axis. Clin Endocrinol. 1994;40:603-669.
13. Huebener KH, Treugut H. Adrenal cortex dysfunction. CT findings. Radiology. 1984;150:195-199.
14. Karstaedt N, Sagel SS, Stanley RJ, et al. Computed tomography of the adrenal gland. Radiology. 1978;129:723-730.
15. Vincent JM, Morrison ID, Armstrong P. The size of normal adrenal glands on computed tomography. Clin Radiol. 1994;49:453-455.
16. Cleare AJ, Bearn J, Allain T, et al. Contrasting neuroendocrine response in depression and chronic fatigue syndrome. J Affect Disord. 1995;35:283-289.
17. Scott LV, Dinan TG. Urinary free cortisol secretion in chronic fatigue syndrome, major depression and in healthy volunteers. J Affect Disord. 1998;47:49-54.
18. Scott LV, Medbak S, Dinan TG. Blunted adrenocorticotropin and cortisol response to corticotropin releasing hormone stimulation in chronic fatigue syndrome. Acta Psychiatr Scand. 1998;97:450-457.
19. Strickland P, Morris R, Wearden A, et al. A comparison of salivary cortisol in chronic fatigue syndrome, community depression and healthy controls. J Affect Disord. 1998;47:191-194.
20. Young AH, Sharpe M, Clements A, et al. Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia). Biol Psychiatry. 1998;43:236-237.
21. Wood B, Wessely S, Papadopoulos A, et al. Salivary cortisol profiles in chronic fatigue syndrome. Neuropsychobiology. 1997;37:1-4.
22. Cleare AJ, Miell J, Heap E, et al. Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. J Clin Endocrinol Metab. 2001;86:3545-3554.
23. Scott LV, Reznek R, Martin A, et al. Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study. Psychoneuroendocrinology. 1999;24:759-768.
24. Cunningham SK, Moore A, Mc Kenna TJ, et al. Normal cortisol response to corticotropin in patients with secondary adrenal failure. Arch Intern Med. 1983;143:2276-2279.
25. Orth DN, Kovacs WJ. Metyrapone test: the pituitary response to hypocortisolemia. In: Wilson JD, et al., eds. Williams Textbook of Endocrinology. Philadelphia: WB Saunders; 1998:620-621.
26. Keleştimur F, Ünlü Y, Özesmi M, et al. A hormonal and radiological evaluation of adrenal gland in patients whit acute or chronic pulmonary tuberculosis. Clin Endocrinol. 1994;41:53-56.
27. Gülmez İ, Keleştimur F, Durak AC, et al. Changes in the size of adrenal glands in acute pulmonary tuberculosis with therapy. Endocr J. 1996;43:573-576.