Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange

Medical Hypotheses

Volumn 64, Issue 5, 2005, Pages 1027-1029

  McCarty, Mark F ^a  

^a Pantox Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM ION; MARINOBUFAGENIN; NATRIURETIC FACTOR; SODIUM ION; UNCLASSIFIED DRUG;

ARTICLE; DIET; ESSENTIAL HYPERTENSION; HUMAN; KIDNEY TUBULE; NATRIURESIS; NEPHROLITHIASIS; NONHUMAN; OSTEOPOROSIS; PLASMA VOLUME; PRIORITY JOURNAL; RISK ASSESSMENT; SALT LOADING; SODIUM CALCIUM EXCHANGE;

EID: 15244343723     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.10.033     Document Type: Article

References (42)

1. MacGregor G.A. Salt - more adverse effects. Am. J. Hypertens. 10:1997;37S-41S
2. de Wardener H.E., MacGregor G.A. Harmful effects of dietary salt in addition to hypertension. J. Hum. Hypertens. 16:2002;213-223
3. Goulding A. Fasting urinary sodium/creatinine in relation to calcium/creatinine and hydroxyproline/creatinine in a general population of women. New Zeal. Med. J. 93:1981;294-297
4. Goulding A., Campbell D. Dietary NaCl loads promote calciuria and bone loss in adult oophorectomized rats consuming a low calcium diet. J. Nutr. 113:1983;1409-1414
5. McParland B.E., Goulding A., Campbell A.J. Dietary salt affects biochemical markers of resorption and formation of bone in elderly women. BMJ. 299:1989;834-835
6. Zarkadas M., Gougeon-Reyburn R., Marliss E.B., Block E., Alton-Mackey M. Sodium chloride supplementation and urinary calcium excretion in postmenopausal women. Am. J. Clin. Nutr. 50:1989;1088-1094
7. Goulding A., McParland B.E. Fasting and 24-h urinary sodium/creatinine values in young and elderly women on low-salt and salt-supplemented regimens. J. Cardiovasc. Pharmacol. 16(Suppl 7):1990;S47-S49
8. Cirillo M., Ciacci C., Laurenzi M., Mellone M., Mazzacca G., De Santo N.G. Salt intake, urinary sodium, and hypercalciuria. Miner. Electrolyte Metab. 23:1997;265-268
9. Martini L.A., Cuppari L., Colugnati F.A., Sigulem D.M., Szejnfeld V.L., Schor N., et al. High sodium chloride intake is associated with low bone density in calcium stone-forming patients. Clin. Nephrol. 54:2000;85-93
10. Sellmeyer D.E., Schloetter M., Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J. Clin. Endocrinol. Metab. 87:2002;2008-2012
11. MacGregor G.A., Cappuccio F.P. The kidney and essential hypertension: a link to osteoporosis? J. Hypertens. 11:1993;781-785
12. Cappuccio F.P., Kalaitzidis R., Duneclift S., Eastwood J.B. Unravelling the links between calcium excretion, salt intake, hypertension, kidney stones and bone metabolism. J. Nephrol. 13:2000;169-177
13. Borghi L., Schianchi T., Meschi T., Guerra A., Allegri F., Maggiore U., et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. New Engl. J. Med. 346:2002;77-84
14. Poujeol P., Chabardes D., Roinel N., De Rouffignac C. Influence of extracellular fluid volume expansion on magnesium, calcium and phosphate handling along the rat nephron. Pflugers Arch. 365:1976;203-211
15. Suki W.N. Calcium and the kidney - from stones to molecules. Verh. K. Acad. Geneeskd. Belg. 52:1990;203-221
16. Coruzzi P., Biggi A., Musiari L., Ceriati R., Mossini G.L., Guerra A., et al. Calcium and sodium handling during volume expansion in essential hypertension. Metabolism. 42:1993;1331-1335
17. Cappuccio F.P., Blackwood A., Sagnella G.A., Markandu N.D., MacGregor G.A. Association between extracellular volume expansion and urinary calcium excretion in normal humans. J. Hypertens. Suppl. 11(Suppl 5):1993;S196-S197
18. Hamlyn J.M., Blaustein M.P. Sodium chloride, extracellular fluid volume, and blood pressure regulation. Am. J. Physiol. 251:1986;F563-F575
19. Kurtz T.W., Al Bander H.A., Morris R.C. Jr. "Salt-sensitive" essential hypertension in men. Is the sodium ion alone important? New Engl. J. Med. 317:1987;1043-1048
20. Blaustein M.P., Hamlyn J.M. Pathogenesis of essential hypertension. A link between dietary salt and high blood pressure. Hypertension. 18:1991;III184-III195
21. Fedorova O.V., Bagrov A.Y. Inhibition of Na/K ATPase from rat aorta by two Na/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different α-subunit isoforms. Am. J. Hypertens. 10:1997;929-935
22. Bagrov A.Y., Fedorova O.V., Dmitrieva R.I., French A.W., Anderson D.E. Plasma marinobufagenin-like and ouabain-like immunoreactivity during saline volume expansion in anesthetized dogs. Cardiovasc. Res. 31:1996;296-305
23. Bagrov A.Y., Dmitrieva R.I., Fedorova O.V., Kazakov G.P., Roukoyatkina N.I., Shpen V.M. Endogenous marinobufagenin-like immunoreactive substance. A possible endogenous Na, K-ATPase inhibitor with vasoconstrictor activity. Am. J. Hypertens. 9:1996;982-990
24. Fedorova O.V., Doris P.A., Bagrov A.Y. Endogenous marinobufagenin-like factor in acute plasma volume expansion. Clin. Exp. Hypertens. 20:1998;581-591
25. Dmitrieva R.I., Bagrov A.Y., Lalli E., Sassone-Corsi P., Stocco D.M., Doris P.A. Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that Is independent of cholesterol side-chain cleavage. Hypertension. 36:2000;442-448
26. Fedorova O.V., Lakatta E.G., Bagrov A.Y. Endogenous Na, K pump ligands are differentially regulated during acute NaCl loading of Dahl rats. Circulation. 102:2000;3009-3014
27. Fedorova O.V., Kolodkin N.I., Agalakova N.I., Lakatta E.G., Bagrov A.Y. Marinobufagenin, an endogenous α-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats. Hypertension. 37:2001;462-466
28. Fedorova O.V., Talan M.I., Agalakova N.I., Lakatta E.G., Bagrov A.Y. Endogenous ligand of α(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension. Circulation. 105:2002;1122-1127
29. +, K(+)-ATPase inhibitors, marinobufagenin and ouabain, on isolated rat aorta. Eur. J. Pharmacol. 274:1995;151-158
30. +-pump in human mesenteric arteries. J. Hypertens. 16:1998;1953-1958
31. Jayakumar A., Cheng L., Liang C.T., Sacktor B. Sodium gradient-dependent calcium uptake in renal basolateral membrane vesicles. Effect of parathyroid hormone. J. Biol. Chem. 259:1984;10827-10833
32. Dominguez J.H., Juhaszova M., Feister H.A. The renal sodium-calcium exchanger. J. Lab. Clin. Med. 119:1992;640-649
33. 2+ exchanger of rat proximal tubule: gene expression and subcellular localization. Am. J. Physiol. 263:1992;F945-F950
34. 2+ exchanger into liposomes. J. Biol. Chem. 260:1985;15473-15476
35. 2+ exchange in distal convoluted tubule cells. Am. J. Physiol. 271:1996;F560-F570
36. 2+ pump in the basal-lateral plasma membranes of kidney cortex during compensatory renal growth. Biochim. Biophys. Acta. 1022:1990;265-272
37. 2+ efflux in immortalized proximal tubule cells. J. Gen. Physiol. 109:1997;217-228
38. Farman N. Na, K-pump expression and distribution in the nephron. Miner. Electrolyte Metab. 22:1996;272-278
39. Lucking K., Nielsen J.M., Pedersen P.A., Jorgensen P.L. Na-K-ATPase isoform (α3, α2, α1) abundance in rat kidney estimated by competitive RT-PCR and ouabain binding. Am. J. Physiol. 271:1996;F253-F260
40. Seok J.H., Hong J.H., Jeon J.R., Hur G.M., Sung J.Y., Lee J.H. Aldosterone directly induces Na, K-ATPase α1-subunit mRNA in the renal cortex of rat. Biochem. Mol. Biol. Int. 47:1999;251-254
41. Hayward A.L., Hinojos C.A., Nurowska B., Hewetson A., Sabatini S., Oefner P.J., et al. Altered sodium pump α and γ subunit gene expression in nephron segments from hypertensive rats. J. Hypertens. 17:1999;1081-1087
42. Chang C.S., Kirk R.G., Lee P. Presence of immunoreactive α3 subunit isoform of Na, K-ATPase in mitochondria of kidney. Kidney Int. 54:1998;457-463