The novel GABA adamantane derivative (AdGABA): Design, synthesis, and activity relationship with gabapentin

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 8, 2005, Pages 2791-2798

  Zoidis, Grigoris ^a   Papanastasiou, Ioannis ^a   Dotsikas, Ioannis ^a   Sandoval, Alejandro ^b   Dos Santos, Raquel Gouvea ^c   Papadopoulou Daifoti, Zeta ^d   Vamvakides, Alexander ^d   Kolocouris, Nicolas ^a   Felix, Ricardo ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR   (Brazil)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

AdGABA; Anticonvulsant; Ca2+ channels; Gabapentin

Indexed keywords

2 AMINOMETHYL 2 TRICYCLO[3.3.1.1 1,7 ]DECANEACETIC ACID; 2 CYANO 2 TRICYCLO[3.3.1.1 1,7 ]DECANEACETIC ACID; ADAMANTANE DERIVATIVE; DECANE; GABAPENTIN; PENTETRAZOLE; SEMICARBAZIDE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG STABILITY; DRUG SYNTHESIS; EMBRYO; GRAND MAL EPILEPSY; HOT PLATE TEST; HUMAN; HUMAN CELL; HYDROGENATION; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; RAT; TONIC SEIZURE;

EID: 15244342944     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.030     Document Type: Article

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