A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes

Psychiatric Genetics

Volumn 8, Issue 3, 1998, Pages 175-181

  Millar, J K ^a   Brown, J ^b   Maule, J C ^a   Shibasaki, Y ^a   Christie, S ^a   Lawson, D ^a   Anderson, S ^a   Wilson Annan, J C ^a   Devon, R S ^a   St Clair, D M ^b   Blackwood, D H R ^a,c   Muir, W J ^a   Porteous, D J ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ROYAL EDINBURGH HOSPITAL   (United Kingdom)

Author keywords

Gene identification; Long range restriction map; Schizophrenia; Translocation

Indexed keywords

ARTICLE; CHROMOSOME 11; CHROMOSOME TRANSLOCATION; CPG ISLAND; GENE EXPRESSION; HUMAN; HUMAN CELL; MENTAL DISEASE; PEDIGREE; PRIORITY JOURNAL; RESTRICTION MAPPING; SCHIZOPHRENIA; UNITED KINGDOM;

EID: 15144357926     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199800830-00007     Document Type: Article

References (22)

1. Arveiler B (1994). Construction of chromosome-specific libraries of yeast artificial chromosome recombinants from somatic hybrid cell lines. In: Chromosome analysis protocols. Gosden Jr (editor). Totowa, NJ: Humana Press, pp. 379-402.
2. Brookes AJ, Slorach EM, Evans KL, Thomson ML, Gosden CM, Muir WJ, Porteous DJ (1995). Identifying genes within microdissected genomic DNA: isolation of brain expressed genes from a translocation region associated with inherited mental illness. Mamm Genome 6:257-262.
3. Burke DT, Carle GF, Olson MV (1987). Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236:806-812.
4. Devon RS, Evans KL, Maule JC, Christie S, Anderson S, Brown J et al. (1997). Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia. Am J Med Genet 74:82-90.
5. Evans KL, Brown J, Shibasaki Y, Devon RS, He L, Arveiler B et al. (1995). A contiguous clone map over 3 Mb on the long arm of chromosome 11 across a balanced translocation associated with schizophrenia. Genomics 28:420-428.
6. Fantes J, Redeker B, Breen M, Boyle S, Brown J, Fletcher J et al. (1995). Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype. Hum Mol Gen 4:415-422.
7. Fletcher JM, Evans K, Baillie D, Byrd P, Hanratty D, Leach S et al. (1993). Schizophrenia-associated chromosome 11q21 translocation - identification of flanking markers and development of chromosome 11q fragment hybrids as cloning and mapping resources. Am J Hum Genet 52:478-490.
8. Kirov G, Murray R (1997). The molecular genetics of schizophrenia: progress so far. Mol Med Today 3:124-130.
9. Lehrach H, Drmanac R, Hoheisel J, Larin Z, Lennon G. Monaco AP et al. (1990). Hybridization fingerprinting in genome mapping and sequencing in genome analysis. In: Genetic and physical mapping. Davies KE, Tilghman SM (editors). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 39-81.
10. Maule JC (1997). Physical mapping by pulsed-field gel electrophoresis. In: Boultwood J ed. Gene isolation and mapping. Totowa, NJ: Humana Press, pp. 93-121.
11. Maule JC, Porteous DJ, Brookes AJ (1994). An improved method for recovering intact pulsed field gel purified DNA of at least 1.6 megabases. Nucl Acids Res 22:3245-3246.
12. McGuffin P, Owen MJ, Farmer AE (1995). Genetic basis of schizophrenia. Lancet 346:678-682.
13. Muir WJ, Gosden CM, Brookes AJ, Fantes J, Evans KL, Maguire SM et al. (1995). Direct microdissection and microcloning of a translocation breakpoint region. t(1;11)(q42.2;q21), associated with schizophrenia. Cytogenet Cell Genet 70:35-40.
14. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF (1995). Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mellb melatonin receptor. Proc Natl Acad Sci 92:8734-8738.
15. Rosier M-F, Reguigne-Arnould I, Couillin P, Devignes M-D, Auffray C (1995). Regional assignment of 68 new human gene transcripts on chromosome 11. Genome Res 5:60-70.
16. Sambrook J, Fritsch EF, Maniatis T (1989). Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
17. Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K et al. (1996). A gene map of the human genome. Science 274:540-546.
18. Shibasaki Y, Maule JC, Devon RS, Slorach EM, Gosden JR, Porteous DJ, Brookes AJ (1995). Catch-linker +PCR labelling - a simple method to generate fluorescence in-situ hybridization probes from yeast artificial chromosomes. PCR Methods Appl 4:209-211.
19. St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G et al. (1990). Association within a family of a balanced autosomal translocation with major mental-illness. Lancet 336:13-16.
20. Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P et al. (1992). A second-generation linkage map of the human genome. Nature 359:794-801.
21. Wilson-Annan JC, Blackwood DHR, Muir W, Millar JK, Porteous DJ (1997) An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) which co-segregates with mental illness. Psychiatr Genet. 7:171-174.
22. Wirth J (1996). Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum Genet 97:186-193.