Immunodetection of PrP(Sc) in spleens of some scrapie-infected sheep but not BSE-infected cows

Journal of General Virology

Volumn 78, Issue 9, 1997, Pages 2389-2396

  Somerville, Robert A ^a   Birkett, Christopher R ^a   Farquhar, Christine F ^a   Hunter, Nora ^a   Goldmann, Wilfred ^a   Dornan, Jaqueline ^a   Grover, Diana ^a   Hennion, Ruth M ^a   Percy, Claire ^a   Foster, James ^a   Jeffrey, Martin ^b  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b Lasswade Veterinary Laboratory   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CONTROLLED STUDY; MOLECULAR WEIGHT; NERVOUS SYSTEM; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SCRAPIE; SHEEP; SPLEEN;

ANIMALIA; BOS TAURUS; BOVINAE; GALLUS GALLUS; OVIS ARIES;

EID: 15144352811     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-9-2389     Document Type: Article

References (39)

1. Akita, E. M. & Nakai, S. (1992). Immunoglobulins from egg yolk: isolation and purification. Journal of Food Science 57, 629-634.
2. Akita, E. M. & Nakai, S. (1993). Production and purification of Fab' fragments from chicken egg-yolk immunoglobulin-Y (IgY). Journal of Immunological Methods 162, 155-164.
3. Bruce, M. E., McBride, P. A. & Farquhar, C. F. (1989). Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie. Neuroscience Letters 102, 1-6.
4. Dickinson, A. G. (1976). Scrapie in sheep and goats. Frontiers of Biology 44, 209-241.
5. Endo, T., Groth, D., Prusiner, S. B. & Kobata, A. (1989). Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein. Biochemistry 28, 8380-8388.
6. Farquhar, C. F., Somerville, R. A. & Ritchie, L. A. (1989). Post-mortem immunodiagnosis of scrapie and bovine spongiform encephalopathy. Journal of Virological Methods 24, 215-221.
7. Farquhar, C. F., Dornan, J., Somerville, R. A., Tunstall, A. M. & Hope, J. (1994). Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie. Journal of General Virology 75, 495-504.
8. Farquhar, C. F., Dornan, J., Moore, R. C., Somerville, R. A., Tunstall, A. M. & Hope, J. (1996). Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy. Journal of General Virology 77, 1941-1946.
9. Foster, J. D. & Dickinson, A. G. (1988). The unusual properties of CH1641, a sheep-passaged isolate of scrapie. Veterinary Record 123, 5-8.
10. Foster, J. D., Hope, J. & Fraser, H. (1993). Transmission of bovine spongiform encephalopathy to sheep and goats. Veterinary Record 133, 339-341.
11. Foster, J. D., Bruce, M., McConnell, I., Chree, A. & Fraser, H. (1996). Detection of BSE infectivity in brain and spleen of experimentally infected sheep. Veterinary Record 138, 546-548.
12. Fraser, H. & Foster, J. (1993). Transmission to mice, sheep and goats and bioassay of bovine tissues. In Transmissible Spongiform Encephalopathies, pp. 145-159. Edited by R. Bradley & B. Marchant. Brussels, Belgium: Commission of the European Communities.
13. Goldmann, W., Hunter, N., Martin, T., Dawson, M. & Hope, J. (1991). Different forms of the bovine PrP gene have five or six copies of a short G-C-rich element within the protein-coding exon. Journal of General Virology 72, 201-204.
14. Goldmann, W., Hunter, N., Smith, G., Foster, J. & Hope, J. (1994). PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. Journal of General Virology 75, 989-995.
15. Hadlow, W. J., Kennedy, R. C. & Race, R. E. (1982). Natural infection of Suffolk sheep with scrapie virus. Journal of Infectious Diseases 146, 657-664.
16. Hope, J., Morton, L. J. D., Farquhar, C. F., Multhaup, G., Beyreuther, K. & Kimberlin, R. H. (1986). The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge-distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP). EMBO Journal 5, 2591-2597.
17. Hunter, N., Goldmann, W., Smith, G. & Hope, J. (1994a). The association of a codon-136 PrP gene variant with the occurrence of natural scrapie. Archives of Virology 137, 171-177.
18. Hunter, N., Goldmann, W., Smith, G. & Hope, J. (1994b). Frequencies of PrP gene variants in healthy cattle and cattle with BSE in Scotland. Veterinary Record 135, 400-403.
19. Hunter, N., Foster, J. D., Goldmann, W., Stear, M. J. Hope, J. & Bostock, C. (1996). Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Archives of Virology 141, 809-824.
20. Ikeqami, Y., Ito, M., Isomura, H., Momotani, E., Sasaki, K., Muramatsu, Y., Ishiguro, N. & Shinagawa, M. (1991). Pre-clinical and clinical diagnosis of scrapie by detection of PrP protein in tissues of sheep. Veterinary Record 128, 271-275.
21. Jensenius, J. C., Andersen, I., Hau, J., Crone, M. & Koch, C. (1981). Eggs: conveniently packaged antibodies. Methods for purification of yolk IgG. Journal of Immunological Methods 46, 63-68.
22. Meyer, R. K., McKinley, M. P., Bowman, K. A., Braunfeld, M. B., Barry, R. A. & Prusiner, S. B. (1986). Separation and properties of cellular and scrapie prion proteins. Proceedings of the National Academy of Sciences, USA 83, 2310-2314.
23. Mohri, S., Farquhar, C. F., Somerville, R. A., Jeffrey, M., Foster, J. & Hope, J. (1992). Immunodetection of a disease specific PrP fraction in scrapie-affected sheep and BSE-affected cattle. Veterinary Record 131, 537-539.
24. Sc in sheep at the preclinical stage of scrapie and its significance for diagnosis of insidious infection. Archives of Virology 134, 427-432.
25. Neville, D. M. (1971). Molecular weight determination of protein-dodecyl sulphate complexes by gel electrophoresis in a discontinuous buffer system. Journal of Biological Chemistry 246, 6328-6334.
26. Sc mainly in Suffolk sheep. Journal of Veterinary Medical Science 56, 627-632.
27. Race, R., Ernst, D., Jenny, A., Taylor, W., Sutton, D. & Caughey, B. (1992). Diagnostic implications of detection of proteinase K-resistant protein in spleen, lymph nodes and brain of sheep. American Journal of Veterinary Research 53, 883-889.
28. Rubenstein, R., Merz, P. A., Kascsak, R. J., Carp, R. I, Scalici, C. L., Fama, C. L. & Wisniewski, H. M. (1987). Detection of scrapie-associated fibrils (SAF) and SAF proteins from scrapie-affected sheep. Journal of Infectious Diseases 156, 36-42.
29. Schreuder, B. E. C., van Keulen, L. J. M., Vromans, M. E. W., Langeveld, J. P. M. & Smits, M. A. (1996). Pre-clinical test for prion diseases. Nature 381, 563.
30. Shinagawa, M., Muramatsu, Y., Onodera, A., Matsui, T., Horiuchi, M., Ishiguro, N. & Nakagawa, M. (1993). Familial scrapie cases with shortened incubation periods. Journal of Veterinary Medical Science 55, 665-667.
31. Sc in Icelandic sheep naturally infected with scrapie. Annals of the New York Academy of Sciences 724, 304-309.
32. Somerville, R. A. (1991). The transmissible agent causing scrapie must contain more than protein. Reviews in Medical Virology 1, 131-139.
33. Somerville, R. A. & Ritchie, L. A. (1990). Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. Journal of General Virology 71, 833-839.
34. Somerville, R. A., Ritehie, L. A. & Gibson, P. H. (1989). Structural and biochemical evidence that scrapie-associated fibrils assemble in vivo. Journal of General Virology 70, 25-35.
35. Towbin, H., Staëhelin, T. & Gordon, J. (1979). Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, USA 76, 4350-4354.
36. van Keulen, L. J. M., Schreuder, B. E. C., Melöen, R. H., Mooijharkes, G., Vromans, M. E. W. & Langeveld, J. P. M. (1996). Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. Journal of Clinical Microbiology 34, 1228-1231.
37. Wells, G. A. H., Dawson, M., Hawkins, S. A. C., Green, R. B., Dexter, I., Francis, M. E., Simmons, M. M., Austin, A. R. & Horigan, M. W. (1994). Infectivity in the ileum of cattle challenged orally with bovine spongiform encephalopathy. Veterinary Record 35, 40-41.
38. Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., Poser, S., Pocchiari, M., Hofman, A. & Smith, P. G. (1996). A new variant of Creutzfeldt Jakob disease in the UK. Lancet 347, 921-925.
39. Yokoyama, H., Peralta, R. C., Horikoshi, T., Hiraoka, J., Ikemori, Y., Kuroki, M. & Kodama, Y. (1993). A two-step procedure for purification of hen egg yolk immunoglobulin G: utilisation of hydroxypropylmethyl cellulose phthalate and synthetic affinity ligand gel (Avid AL). Poultry Science 72, 275-281.