New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3- dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: Variations of the dihydrobenzofuran ring

Journal of Medicinal Chemistry

Volumn 41, Issue 7, 1998, Pages 1124-1137

  Janusz, John M ^a   Young, Patricia A ^a   Scherz, Michael W ^a   Enzweiler, Kevin ^a   Wu, Laurence I ^a   Gan, Lixian ^a   Pikul, Stanislaw ^a   McDow Dunham, Kelly L ^a   Johnson, Carl R ^b   Senanayake, C B ^b   Kellstein, David E ^a   Green, Shelley A ^a   Tulich, Julie L ^a   Rosario Jansen, Theresa ^a   Jack Magrisso, I ^a   Wehmeyer, Kenneth R ^a   Kuhlenbeck, Deborah L ^a   Eichhold, Thomas H ^a   Dobson, Roy L M ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; CARRAGEENAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLQUINONE;

ADJUVANT ARTHRITIS; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MAST CELL LEUKEMIA; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAIN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; BENZOFURANS; BLOOD PLATELETS; CARRAGEENAN; CYCLOOXYGENASE INHIBITORS; EDEMA; HUMANS; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY;

EID: 15144351712     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970680p     Document Type: Article

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