4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity

Journal of Medicinal Chemistry

Volumn 40, Issue 5, 1997, Pages 754-765

  Carling, Robert W ^a   Leeson, Paul D ^a   Moore, Kevin W ^a   Moyes, Christopher R ^a   Duncton, Matthew ^a   Hudson, Martin L ^a   Baker, Raymond ^a   Foster, Alan C ^a   Grimwood, Sarah ^a   Kemp, John A ^a   Marshall, George R ^a   Tricklebank, Mark D ^a   Saywell, Kay L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 3 PHENYLQUINOLIN 2(1H) ONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; HYDROGEN BOND; METHYLATION; PROTEIN BINDING; SEIZURE; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; ANTICONVULSANTS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, INBRED DBA; MOLECULAR STRUCTURE; N-METHYLASPARTATE; QUINOLONES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15144351047     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9605492     Document Type: Article

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