메뉴 건너뛰기




Volumn 124, Issue 3-4, 1998, Pages 191-198

5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma: A multicentric randomized study

Author keywords

5 fluorouracil; Advanced colon cancer; Biochemical modulation; Immunotherapy; Interferon 2a

Indexed keywords

ALPHA2A INTERFERON; FLUOROURACIL;

EID: 15144344797     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050154     Document Type: Article
Times cited : (15)

References (50)
  • 1
    • 0027412002 scopus 로고
    • Folinic acid improve 5-fluorouracil activity in vivo. Results of a phase III study comparing 5-fluorouracil to 5-fluorouracil and folinic acid in advanced colon cancer patients
    • Bobbio Pallavicini E, Porta C, Moroni M, Spaghi A, Casagranda I, Nastasi G (1993) Folinic acid improve 5-fluorouracil activity in vivo. Results of a phase III study comparing 5-fluorouracil to 5-fluorouracil and folinic acid in advanced colon cancer patients. J Chemother 5:52-55
    • (1993) J Chemother , vol.5 , pp. 52-55
    • Bobbio Pallavicini, E.1    Porta, C.2    Moroni, M.3    Spaghi, A.4    Casagranda, I.5    Nastasi, G.6
  • 2
    • 0022373581 scopus 로고
    • A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma
    • Buroker TR, Moertel CG, Fleming TR, Everson LK, Cullinan SA, Krook JE et al. (1985) A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma. J Clin Oncol 3:1624-1631
    • (1985) J Clin Oncol , vol.3 , pp. 1624-1631
    • Buroker, T.R.1    Moertel, C.G.2    Fleming, T.R.3    Everson, L.K.4    Cullinan, S.A.5    Krook, J.E.6
  • 4
    • 0025043811 scopus 로고
    • Interaction of interferon and 5-fluorouracil in the H630 human colon carcinoma cell line
    • Chu E, Zinn S, Boarman D, Allegra CJ (1990) Interaction of interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res 50:5834-5840
    • (1990) Cancer Res , vol.50 , pp. 5834-5840
    • Chu, E.1    Zinn, S.2    Boarman, D.3    Allegra, C.J.4
  • 5
    • 0027416220 scopus 로고
    • Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma
    • Chu E, Voeller DM, Johnston PG, Allegra CJ (1993) Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. Mol Pharmacol 43:527-533
    • (1993) Mol Pharmacol , vol.43 , pp. 527-533
    • Chu, E.1    Voeller, D.M.2    Johnston, P.G.3    Allegra, C.J.4
  • 6
    • 0027403409 scopus 로고
    • Phase I and pharmacokinetic study of infusional fluorouracil combined with recombinant interferon alpha-2b in patients with advanced cancer
    • Danhauser LL, Freimann JH, Gilchrist TL, Gutterman JU, Hunter CY, Yeomans AC, Markowitz AB (1993) Phase I and pharmacokinetic study of infusional fluorouracil combined with recombinant interferon alpha-2b in patients with advanced cancer. J Clin Oncol 11:751-761
    • (1993) J Clin Oncol , vol.11 , pp. 751-761
    • Danhauser, L.L.1    Freimann, J.H.2    Gilchrist, T.L.3    Gutterman, J.U.4    Hunter, C.Y.5    Yeomans, A.C.6    Markowitz, A.B.7
  • 7
    • 15144359350 scopus 로고
    • 5-Fluorouracil alone versus high dose folinic acid and 5-FU in advanced colorectal cancer. A randomized trial of the Italian Oncology Group for Clinical Research
    • Di Costanzo F, Bartolucci R, Sofra M (1989) 5-Fluorouracil alone versus high dose folinic acid and 5-FU in advanced colorectal cancer. A randomized trial of the Italian Oncology Group for Clinical Research. Proc ASCO 8:109
    • (1989) Proc ASCO , vol.8 , pp. 109
    • Di Costanzo, F.1    Bartolucci, R.2    Sofra, M.3
  • 8
    • 34547933906 scopus 로고
    • High dose folinic acid (FA) and 5FU alone or combined with hydroxyurea (HU) in advanced colorectal cancer (CRC): A randomized trial of the Italian Oncology Group for Clinical Research (GOIRC)
    • Di Costanzo F, Bartolucci R, Piccinini L, Sabbatini R, Leonardi F, Corgna E, Figoli F, Passalacqua R, Algeri R, Finardi C (1992) High dose folinic acid (FA) and 5FU alone or combined with hydroxyurea (HU) in advanced colorectal cancer (CRC): a randomized trial of the Italian Oncology Group for Clinical Research (GOIRC). Ann Oncol 3 [Suppl 5]:190
    • (1992) Ann Oncol , vol.3 , Issue.5 SUPPL. , pp. 190
    • Di Costanzo, F.1    Bartolucci, R.2    Piccinini, L.3    Sabbatini, R.4    Leonardi, F.5    Corgna, E.6    Figoli, F.7    Passalacqua, R.8    Algeri, R.9    Finardi, C.10
  • 9
    • 0025261244 scopus 로고
    • Prospective randomized comparison of fluorouracil versus fluorouracil and high dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancers in patients previously unexposed to chemotherapy
    • Doroshow JH, Multhauf P, Leong L, Margolin K, Litchlield T, Akamn S (1990) Prospective randomized comparison of fluorouracil versus fluorouracil and high dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancers in patients previously unexposed to chemotherapy. J Clin Oncol 8:491-501
    • (1990) J Clin Oncol , vol.8 , pp. 491-501
    • Doroshow, J.H.1    Multhauf, P.2    Leong, L.3    Margolin, K.4    Litchlield, T.5    Akamn, S.6
  • 11
    • 0023718558 scopus 로고
    • Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: Antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites
    • Elias L, Crissman HA (1988) Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites. Cancer Res 48:4861-4873
    • (1988) Cancer Res , vol.48 , pp. 4861-4873
    • Elias, L.1    Crissman, H.A.2
  • 12
    • 0024414582 scopus 로고
    • Interferon effects upon fluorouracil metabolism by HL-60 cells
    • Elias L, Sandoval JM (1989) Interferon effects upon fluorouracil metabolism by HL-60 cells. Biochem Biophys Res Commun 163:867-874
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 867-874
    • Elias, L.1    Sandoval, J.M.2
  • 13
    • 0023874456 scopus 로고
    • A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
    • Erlichman C, Fine S, Wong A, Elhakim T (1988) A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 6:469-475
    • (1988) J Clin Oncol , vol.6 , pp. 469-475
    • Erlichman, C.1    Fine, S.2    Wong, A.3    Elhakim, T.4
  • 14
    • 0019415841 scopus 로고
    • Effect of excess of folate and deoxyinosine on the activity and site of action of 5-fluorouracil
    • Evans RM, Laskin GD, Hakala MT (1981) Effect of excess of folate and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res 41:3288-3295
    • (1981) Cancer Res , vol.41 , pp. 3288-3295
    • Evans, R.M.1    Laskin, G.D.2    Hakala, M.T.3
  • 16
    • 0020564133 scopus 로고
    • Inhibition of cell division by interferons. The relationship between changes in utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells
    • Gewert DR, Moore G, Clemens MJ (1983) Inhibition of cell division by interferons. The relationship between changes in utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells. Biochem J 214:983-990
    • (1983) Biochem J , vol.214 , pp. 983-990
    • Gewert, D.R.1    Moore, G.2    Clemens, M.J.3
  • 18
    • 6544226100 scopus 로고
    • Randomized multicenter trial of sequential methotrexate and 5-fluorouracil (5-FU) vs 5-FU alone in metastatic colorectal carcinoma
    • Hermann R, Knutt A, Kleeberg U, et al. (1986) Randomized multicenter trial of sequential methotrexate and 5-fluorouracil (5-FU) vs 5-FU alone in metastatic colorectal carcinoma. Proc ASCO 5:91
    • (1986) Proc ASCO , vol.5 , pp. 91
    • Hermann, R.1    Knutt, A.2    Kleeberg, U.3
  • 21
    • 0026513546 scopus 로고
    • Alfa-2A interferon and 5-fluorouracil for advanced colorectal carcinoma: The Memorial Sloan-Kettering experience
    • Kemeny N, Younes A (1992) Alfa-2A interferon and 5-fluorouracil for advanced colorectal carcinoma: the Memorial Sloan-Kettering experience. Semin Oncol 19:171-175
    • (1992) Semin Oncol , vol.19 , pp. 171-175
    • Kemeny, N.1    Younes, A.2
  • 22
    • 0023790494 scopus 로고
    • Cisplatin + 5-fluorouracil versus 5-fluorouracil alone in advanced colorectal cancer: A randomized study
    • Labianca R, Pancera G, Cesana B, Clerici M, Montinari F, Luporini G (1988) Cisplatin + 5-fluorouracil versus 5-fluorouracil alone in advanced colorectal cancer: a randomized study. Eur J Cancer Clin Oncol 24:1579-1581
    • (1988) Eur J Cancer Clin Oncol , vol.24 , pp. 1579-1581
    • Labianca, R.1    Pancera, G.2    Cesana, B.3    Clerici, M.4    Montinari, F.5    Luporini, G.6
  • 23
    • 0025991253 scopus 로고
    • Folinic acid + 5-fluorouracil (5FU) versus equidose 5FU in advanced colorectal cancer: Phase III study of GISCAD (Italian Group for Study of Digestive Tract Cancer)
    • Labianca R, Pancera G, Aitini E, Barni S, Beretta A, Beretta GD (1991) Folinic acid + 5-fluorouracil (5FU) versus equidose 5FU in advanced colorectal cancer: phase III study of GISCAD (Italian Group for Study of Digestive Tract Cancer). Ann Oncol 2:673-679
    • (1991) Ann Oncol , vol.2 , pp. 673-679
    • Labianca, R.1    Pancera, G.2    Aitini, E.3    Barni, S.4    Beretta, A.5    Beretta, G.D.6
  • 24
    • 0027360285 scopus 로고
    • A randomized, double-blind trial of fluorouracil plus placebo versus fluorouracil plus oral leucovorin in patients with metastatic colorectal cancer
    • Laufman L, Bukowski R, Collier M, Sullivan B, McKinnis R, Clendennin N, Guaspari A, Brenkman W (1993) A randomized, double-blind trial of fluorouracil plus placebo versus fluorouracil plus oral leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 11:1888-1893
    • (1993) J Clin Oncol , vol.11 , pp. 1888-1893
    • Laufman, L.1    Bukowski, R.2    Collier, M.3    Sullivan, B.4    McKinnis, R.5    Clendennin, N.6    Guaspari, A.7    Brenkman, W.8
  • 26
    • 0023896783 scopus 로고
    • A prospective randomized trial of fluorouracil versus fluorouracil plus cisplatin in the treatment of metastatic colorectal cancer: A Hoosier Oncology Group trial
    • Loehrer PJ, Turner S, Kubilis P, Hui S, Correa J, Ansari R, Stephens D, Woodburn R, Meyer S (1988) A prospective randomized trial of fluorouracil versus fluorouracil plus cisplatin in the treatment of metastatic colorectal cancer: a Hoosier Oncology Group trial. J Clin Oncol 6:642-648
    • (1988) J Clin Oncol , vol.6 , pp. 642-648
    • Loehrer, P.J.1    Turner, S.2    Kubilis, P.3    Hui, S.4    Correa, J.5    Ansari, R.6    Stephens, D.7    Woodburn, R.8    Meyer, S.9
  • 27
    • 84910702552 scopus 로고
    • Randomized comparison of 5-FU vs. 5-FU/medium dose leucovorin in metastatic colorectal cancer
    • Loffler T, Korsten FW, Burghard F (1989) Randomized comparison of 5-FU vs. 5-FU/medium dose leucovorin in metastatic colorectal cancer. Eur Conf Clin Oncol O-0628
    • (1989) Eur Conf Clin Oncol
    • Loffler, T.1    Korsten, F.W.2    Burghard, F.3
  • 28
    • 0025381866 scopus 로고
    • Clinical trials with 5-fluorouracil, folinic acid and cisplatin in patients with gastrointestinal malignancies
    • Madajewicz S, Avvento L (1990) Clinical trials with 5-fluorouracil, folinic acid and cisplatin in patients with gastrointestinal malignancies. J Chemother 2 [Suppl 1]:33-37
    • (1990) J Chemother , vol.2 , Issue.1 SUPPL. , pp. 33-37
    • Madajewicz, S.1    Avvento, L.2
  • 29
    • 0026759016 scopus 로고
    • Weekly regimen of 5FU vs 5FU + intermediate dose folinic acid in the treatment of advanced colorectal cancer
    • Martoni A, Cricca A, Guaraldi M, Covizzi M, Farris A, Pannuti F (1992) Weekly regimen of 5FU vs 5FU + intermediate dose folinic acid in the treatment of advanced colorectal cancer. Anticancer Res 12:607-612
    • (1992) Anticancer Res , vol.12 , pp. 607-612
    • Martoni, A.1    Cricca, A.2    Guaraldi, M.3    Covizzi, M.4    Farris, A.5    Pannuti, F.6
  • 31
    • 0020696393 scopus 로고
    • Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originated from neoplastic tissues
    • Miyoshi T, Ogawa S, Kanamori T, et al. (1983) Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originated from neoplastic tissues. Cancer Lett 17:239-247
    • (1983) Cancer Lett , vol.17 , pp. 239-247
    • Miyoshi, T.1    Ogawa, S.2    Kanamori, T.3
  • 32
    • 0021636441 scopus 로고
    • Minimal activity of recombinant clone a interferon in metastatic colon cancer
    • Neefe JR, Sigals R, Ayoob M, Schein PS (1984) Minimal activity of recombinant clone A interferon in metastatic colon cancer. J Biol Response Mod 3:366-370
    • (1984) J Biol Response Mod , vol.3 , pp. 366-370
    • Neefe, J.R.1    Sigals, R.2    Ayoob, M.3    Schein, P.S.4
  • 33
    • 0024200604 scopus 로고
    • A randomized trial of 5-fluorouracil and high dose leucovorin in untreated advanced colorectal cancer patients
    • Nobile MT, Canobbio L, Sobrero A, Galligioni E, Vidili MG, Fassio T (1988) A randomized trial of 5-fluorouracil and high dose leucovorin in untreated advanced colorectal cancer patients. Adv Exp Med Biol 244:213-218
    • (1988) Adv Exp Med Biol , vol.244 , pp. 213-218
    • Nobile, M.T.1    Canobbio, L.2    Sobrero, A.3    Galligioni, E.4    Vidili, M.G.5    Fassio, T.6
  • 34
    • 0025937453 scopus 로고
    • Combined 5-fluorouracil and recombinant alpha-2a interferon vs. 5-fluorouracil alone in metastatic colorectal carcinoma: A multicenter randomized study
    • Palmeri S, Gebbia V (1991) Combined 5-fluorouracil and recombinant alpha-2A interferon vs. 5-fluorouracil alone in metastatic colorectal carcinoma: a multicenter randomized study. J Surg Oncol Suppl 2:134-136
    • (1991) J Surg Oncol , Issue.2 SUPPL. , pp. 134-136
    • Palmeri, S.1    Gebbia, V.2
  • 35
    • 0025241955 scopus 로고
    • 5-Fluorouracil and recombinant alpha-interferon-2a in the treatment of advanced colorectal carcinoma: A dose-optimization study
    • Palmeri S, Gebbia V, Rausa L (1990) 5-Fluorouracil and recombinant alpha-interferon-2a in the treatment of advanced colorectal carcinoma: a dose-optimization study. J Chemother 2:327-330
    • (1990) J Chemother , vol.2 , pp. 327-330
    • Palmeri, S.1    Gebbia, V.2    Rausa, L.3
  • 36
    • 0024385167 scopus 로고
    • The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial
    • Petrelli N, Douglass HO, Herrera L, Russell D, Stablein DM, Bruckner HW (1989) The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. J Clin Oncol 7:1419-1426
    • (1989) J Clin Oncol , vol.7 , pp. 1419-1426
    • Petrelli, N.1    Douglass, H.O.2    Herrera, L.3    Russell, D.4    Stablein, D.M.5    Bruckner, H.W.6
  • 37
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, Burke P, Creaven P, Stule J (1987) A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559-1565
    • (1987) J Clin Oncol , vol.5 , pp. 1559-1565
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3    Burke, P.4    Creaven, P.5    Stule, J.6
  • 38
    • 0021284687 scopus 로고
    • Interferon inhibition of thymidine incorporation into DNA through effects on thymidine transport and uptake
    • Pfeffer LM, Tamm I (1984) Interferon inhibition of thymidine incorporation into DNA through effects on thymidine transport and uptake. J Cell Physiol 121:431-436
    • (1984) J Cell Physiol , vol.121 , pp. 431-436
    • Pfeffer, L.M.1    Tamm, I.2
  • 40
    • 0029055178 scopus 로고
    • Treatment of advanced colorectal cancer with 5-fluorouracil and interferon-α: An overview of clinical trials
    • Raderer M, Scheithauer W (1995) Treatment of advanced colorectal cancer with 5-fluorouracil and interferon-α: an overview of clinical trials. Eur J Cancer 31:1002-1008
    • (1995) Eur J Cancer , vol.31 , pp. 1002-1008
    • Raderer, M.1    Scheithauer, W.2
  • 41
    • 0026600296 scopus 로고
    • Stimulation of 5-fluorouracil metabolic activation by interferon-a in human colon carcinoma cells
    • Schwartz EL, Hoffman M, O'Connor CJ, Wadler S (1992) Stimulation of 5-fluorouracil metabolic activation by interferon-a in human colon carcinoma cells. Biochem Biophys Res Commun 182:1232-1239
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1232-1239
    • Schwartz, E.L.1    Hoffman, M.2    O'Connor, C.J.3    Wadler, S.4
  • 42
    • 0024414365 scopus 로고
    • Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: A randomized trial
    • The Nordic Gastrointestinal Tumor Adjuvant Therapy Group (1989) Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial. J Clin Oncol 7:1437-1446
    • (1989) J Clin Oncol , vol.7 , pp. 1437-1446
  • 43
    • 0005086073 scopus 로고
    • Cytotoxicity of 5-fluoro-2′deoxyuridylate: Requirement for reduced folate cofactors and antagonism by methotrexate
    • Ulmann B, Lee M, Martin DW, Santi DW (1978) Cytotoxicity of 5-fluoro-2′deoxyuridylate: requirement for reduced folate cofactors and antagonism by methotrexate. Proc Natl Acad Sci USA 75:980-983
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 980-983
    • Ulmann, B.1    Lee, M.2    Martin, D.W.3    Santi, D.W.4
  • 44
    • 0024342059 scopus 로고
    • Treatment of patients with advanced colorectal carcinoma with fluorouracil alone, high dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group
    • Valone FH, Friedman MA, Wittlinger PS, Drakes T, Eisenberg PD, Malec M, Hannigan JF, Brown BW (1989) Treatment of patients with advanced colorectal carcinoma with fluorouracil alone, high dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group. J Clin Oncol 7:1427-1436
    • (1989) J Clin Oncol , vol.7 , pp. 1427-1436
    • Valone, F.H.1    Friedman, M.A.2    Wittlinger, P.S.3    Drakes, T.4    Eisenberg, P.D.5    Malec, M.6    Hannigan, J.F.7    Brown, B.W.8
  • 46
    • 0025052138 scopus 로고
    • Interaction of fluorouracil and interferon in human colon cancer cell lines: Cytotoxic and cytokinetic effects
    • Wadler S, Wersto R, Weinberg V, Thompson D, Schwartz EL (1990) Interaction of fluorouracil and interferon in human colon cancer cell lines: cytotoxic and cytokinetic effects. Cancer Res 50:5735-5739
    • (1990) Cancer Res , vol.50 , pp. 5735-5739
    • Wadler, S.1    Wersto, R.2    Weinberg, V.3    Thompson, D.4    Schwartz, E.L.5
  • 47
    • 0025945855 scopus 로고
    • Phase II trial of fluorouracil and recombinant interferon alpha-2a in patients with advanced colorectal carcinoma: An Eastern Cooperative Oncology, Group Study
    • Wadler S, Lambersky B, Atkins M, Kirkwood J, Petrelli N (1991) Phase II trial of fluorouracil and recombinant interferon alpha-2a in patients with advanced colorectal carcinoma: an Eastern Cooperative Oncology, Group Study. J Clin Oncol 9:1806-1810
    • (1991) J Clin Oncol , vol.9 , pp. 1806-1810
    • Wadler, S.1    Lambersky, B.2    Atkins, M.3    Kirkwood, J.4    Petrelli, N.5
  • 48
    • 0019971555 scopus 로고
    • Enhancement of 5-fluorouracil antimetabolic activity by leucovorin, menadione and α-tocopherol
    • Waxman S, Bruckner H (1982) Enhancement of 5-fluorouracil antimetabolic activity by leucovorin, menadione and α-tocopherol. Eur J Cancer Clin Oncol 18:685-692
    • (1982) Eur J Cancer Clin Oncol , vol.18 , pp. 685-692
    • Waxman, S.1    Bruckner, H.2
  • 49
    • 0026525426 scopus 로고
    • Treatment of metastatic colorectal carcinoma with a combination of fluorouracil and recombinant interferon alpha-2b: Preliminary data of a phase II study
    • Weh HJ, Platz D, Braumann D, Buggisch P, Schmiegel WH, Drescher S (1992) Treatment of metastatic colorectal carcinoma with a combination of fluorouracil and recombinant interferon alpha-2b: preliminary data of a phase II study. Semin Oncol 19 [Suppl 2]:180-184
    • (1992) Semin Oncol , vol.19 , Issue.2 SUPPL. , pp. 180-184
    • Weh, H.J.1    Platz, D.2    Braumann, D.3    Buggisch, P.4    Schmiegel, W.H.5    Drescher, S.6
  • 50
    • 0026490284 scopus 로고
    • Decreased catabolism of 5-fluorouracil in peripheral blood mononuclear cells during therapy with 5-fluorouracil, leucovorin and interferon α-2a
    • Yee LK, Allegra CJ, Steinberg SM, Grem JL (1992) Decreased catabolism of 5-fluorouracil in peripheral blood mononuclear cells during therapy with 5-fluorouracil, leucovorin and interferon α-2a. J Natl Cancer Inst 84:1820-1825
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1820-1825
    • Yee, L.K.1    Allegra, C.J.2    Steinberg, S.M.3    Grem, J.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.