Determination of N-nitrosodiethanolamine in cosmetic products by LC-MS-MS

Analytical and Bioanalytical Chemistry

Volumn 381, Issue 3, 2005, Pages 681-685

  Schothorst, R C ^a   Somers, H H J ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Cosmetics; LC MS MS; N nitrosamine; NDELA; The Netherlands

Indexed keywords

LIQUID CHROMATOGRAPHY; MARKETING; MASS SPECTROMETRY;

COSMETICS; FOAM BATHS; N-NITROSODIETHANOLAMINE (NDELA); SHOWER GELS;

AMINES;

BIS(2 HYDROXYETHYL)NITROSAMINE; COSMETIC; SHAMPOO; SOAP; WATER;

ACCURACY; ARTICLE; DILUTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; REPRODUCIBILITY; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; COSMETICS; DIETHYLNITROSAMINE; INDICATORS AND REAGENTS; MASS SPECTROMETRY; METHYLENE CHLORIDE; NETHERLANDS; REPRODUCIBILITY OF RESULTS;

EID: 15044349055     PISSN: 16182642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00216-004-2914-5     Document Type: Article

References (14)

1. Report on Carcinogens (2002) U.S. Department of Health and Human Services, 10th edn. Public Health Service, National Toxicology Program
2. Tricker AR (1997) N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. Eur J Cancer Prev 6:226-268
3. Krul CAM, Zeilmaker MJ, Schothorst RC, Havenaar R (2004) Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions. Food Chem Toxicol 42:51-63
4. Ellen G (1997) Exposure to performed N-Nitroso compounds. In: Eisenbrand G, Bozler G, Nicolai HV (eds) The significance of N-nitrosation of Drugs. Gustav Fischer Verlag, Stuttgart, pp 19-46
5. Ellen G, Egmond E, van Loon JW, Sahertian ET, Tolsma K (1990) Dietary intakes of some essential and non-essential trace elements, nitrate, nitrite and N-nitrosamines by Dutch adults: estimated via a 24-hour duplicate portion study. Food Addit Contam 7:207-221
6. Stephany RW, Schuller PL (1980) Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in The Netherlands using the duplicate portion sampling technique. Oncology 37:203-210
7. Havery DC, Chou HJ (1994) N-Nitrosamines in cosmetic products. Cosmetics Toiletries 109:53-62
8. Commission Directive 92/86/EEC (1992) Off J Eur Comm L325:18-22
9. Schothorst RC, Stephany RW (2001) Occurrence of N-nitrosodiethanolamine (NDELA) in cosmetics from the Dutch market. Int J Cosmetic Sci 23:109-114
10. Verhoef A, Schouten A (2002) Analysis of NDELA in rinse-off cosmetic products. TNO report V4685, Zeist
11. Commission decision of 12 August 2002 implementing council directive 96/23/ec concerning the performance of analytical methods and the interpretation of results - 2002/657/ec (2002) Off J Eur Comm L221:8-36
12. Matyska MT, Pesek JJ, Yang L (2000) Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography. J Chromatogr A 887:487-503
13. Billedeau SM, Heinze TM, Wilkes JG, Thompson HC Jr (1994) Application of the particle beam interface to high-performance liquid chromatography-thermal energy analysis and electron impact mass spectrometry for the detection of non-volatile N-nitrosamines. J Chromatogr A 688:55-65
14. Meyer TA, Powell JB (1991) Quantification of the nitrosamine 2-ethylhexyl-4-(N-methyl-N-nitrosamino) benzoate (NPA-BAO) in sunscreen products. J Assoc Off Anal Chem 74:766-771