PADMA 28: A multi-component herbal preparation with retinoid-like dermal activity but without epidermal effects

Journal of Investigative Dermatology

Volumn 124, Issue 3, 2005, Pages 524-529

  Aslam, Muhammad Nadeem ^a   Fligiel, Helene ^a   Lateef, Humaira ^a   Fisher, Gary J ^a   Ginsburg, Isaac ^b   Varani, James ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Fibroblasts; Keratinocytes; Matrix metalloproteinase; Procollagen; Skin

Indexed keywords

INTERSTITIAL COLLAGENASE; PADMA 28; PROCOLLAGEN; RETINOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELL HYPERPLASIA; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DERMIS; DRUG EFFECT; DRUG FORMULATION; DRUG SYNTHESIS; EPIDERMIS; FIBROBLAST; HERBAL MEDICINE; HUMAN; HUMAN CELL; KERATINOCYTE; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN IRRITATION;

EID: 15044343772     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23596.x     Document Type: Article

References (60)

1. rh) induced by retinoids. J Invest Dermatol 82:632-635, 1984
2. Bhagavathula N, Nerusu K, Ellis CN, et al: Rosiglitzone inhibits biological responses in keratinocytes and signaling events that underlie responsiveness. J Invest Dermatol 122:130-139, 2004
3. Bolego C, Poli A, Cignarella A, Paoletti R: Phytoestrogens: Pharmacological and therapeutic perspectives. Current. Drug Targets 4:77-87, 2003
4. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-771, 1988
5. Braverman IM, Fonferko E: Studies in cutaneous aging: The elastic fiber network. J Invest Dermatol 78:434-443, 1982
6. Chen O, Ostowski J, Whiting G, Hammer L, Currier SJ, Reczek PR: Retinoic acid gamma receptor medites topical retinoid efficacy and irritation in animal models. J Invest Dermatol 104:779-783, 1995
7. Drabaek H, Mehlsen J, Himmelstrup H, Winther K: A botanical compound, PAD-MA 28, increases walking distance in stable intermittent claudication. Angiology 44:863-867, 1993
8. Elder JT, Cromie MA, Griffiths CE, Chambon P, Voorhees JJ.: Stimulus-selective induction of CRABP-II mRNA: A marker for retinoic acid action in human skin. J Invest Dermatol 100:356-359, 1993
9. Fisher GJ, Datta SC, Talwar HS, Wang Z-Q, Varani J, Kang S, Voorhees JJ: The molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature (London) 379:335-338, 1996
10. Fisher GJ, Esmann J, Griffiths CEM, Nickloloff BJ, Voorhees JJ: Cellular, immunological and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 96:699-707, 1991
11. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138:1462-1470, 2002
12. Fisher GJ, Wang Z-Q, Datta SC, Varani J, Kang S, Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. New Engl J Med 337:1419-1428, 1997
13. Gibbs DF, Apel IJ, Warner RO, Weiss SJ, Johnson KJ, Varani J: Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am J Respir Cell Molecular Biol 20:1136-1144, 1999
14. Ginsburg I, Sadovnik M, Sallon S, et al: PADMA-28, a traditional Tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids. Inflammapharmacology 7:47-62, 1999
15. rGya mtsho sDS: Gsoba rig pa' bsten bcos smen bla' dgongs rgyen rgyud bzhi' gsal byed be dur snogpo' mallika zhes bya bu bzhugs so-Smed cha, (Commentary to the rgyud bzhi, The Blue Beryll-volume II). Dharamsala: Tibetan Medical & Astro Institute, 1994
16. Griffiths CEM, Russman G, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ: Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). New Engl J Med 329:530-534, 1993
17. Kang S, Duell EA, Fisher GJ, et al: Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid-binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 105:549-556, 1995
18. Klenerman L, McCabe C, Cogley D, Crerand S, Laing P, White M: Screening for patients at risk of diabetic foot ulceration in a general diabetic outpatient clinic. Diabetic Med 13:561-563, 1996
19. Kligman AM, Balin AK: Aging of human skin. In: Balin AK, Kligman AM (eds). Aging and the Human Skin. New York: Raven Press, 1989; p 1-11
20. Kligman AM, Grove GL, Hirose R, Leyden JJ: Topical tretinoin for photoaged skin. J Am Acad Dermatol 15:836-859, 1986
21. Laing P: The development and complications of diabetic foot ulcers. Amer J Surg 176 (Suppl. 2A):11s-19s, 1998
22. Lavker RM: Structural alterations in exposed and unexposed aged skin. J Invest Dermatol 73:559-566, 1979
23. Lavker RM: Cutaneous aging: Chronologic versus photoaging. In: Gilchrest BA (ed). Photoaging. Cambridge, MA: Blackwell Science, 1995; p 123-135
24. Lovell CR, Smolenski KA, Duance VC, Light ND, Young S, Dysons M: Type I and III collagen content in normal human skin during ageing. Br J Dermatol 419-428, 1987
25. Margolis D, Hoffstad O: Diabetic Neuropathic Foot Ulcers. Diabetes Care 25:10, 2002
26. Margolis DJ, Kantor J, Berlin JA: Healing of diabetic neuropathic foot ulcers receiving standard treatment: A meta-analysis. Diabetes Care 22:692-695, 1999
27. Matzner Y, Sallon S: The effect of Padma 28, a traditional Tibetan herbal preparation, on human neutrophil function. J Clin Lab Immunol 46:13-23, 1995
28. McMichael AJ, Griffiths CEM, Talwar HA, Finkel LJ, Rafal ES, Hamilton TA, Voorhees JJ: Concurrent application of tretinoin (retinoic acid) partially protects against corticosteroid-induced epidermal atrophy. Brit J Dermatol 135:60-64, 1996
29. Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG: Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in a macrophage cell line. Can J Physiol Pharmacol 78:861-866, 2000
30. Montagna W, Kirchner S, Carlisle K: Histology of sun-damaged human skin. J Am Acad Dermatol 21:907-918, 1989
31. Oikrinen A, Kallioinen M: A biochemical and immunohistochemical study of collagen in sun-exposed and protected skin. Photodermatology 6:24-31, 1989
32. Prakash A, Pundit PN, Sharma KL: Studies on wound healing in experimental diabetes. Int Surg 59:25-30, 1974
33. Quan T, He T, Kang S, Voorhees JJ, Fisher GJ: Connective tissue growth factor: Expression in human skin in vivo and inhibition by ultraviolet irradiation. J Invest Dermatol 118:402-408, 2002
34. Reiber GE: The epidemiology of diabetic foot problems. Diabetic Med 13:S6-S11, 1998
35. Reichle F: Das Wissen vom Heilen. Zurich: Oesch Verlag, 2003
36. Sallon S, Beer G, Rosenfeld J, et al: The efficacy of PADMA 28, a herbal preparation, in the treatment of intermittent claudication: A controlled double-blind pilot study with objective assessment of chronic occlusive arterial disease patients. J Vasc Invest 4:129-136, 1998
37. Samochowiec L, Wojcicki J, Kosmider K, Dadej R, Smulski H: Wirksamkeitsprüfung von PADMA 28 bei der Behandlung von Patienten mit chronischen arteriellen Durchblutungsstörungen. Herba Pol 33:29-41, 1987
38. Schräder R, Nachbur B, Mahler F: Wirksamkeit von PADMA 28 auf die Claudicatio intermittens bei chronischer peripherer arterieller Verschlusskrankheit: Kontrollierte Doppelblindstudie. Schweiz med Wochenschr 115/22:752-756, 1985
39. Schwartz E, Cruickshank FA, Christensen CC, Perlish JS, Lebwohl M: Collagen alterations in chronically sun-damaged human skin. Photochem Photobiol 58:841-844, 1993
40. Schwartz E, Cruickshank FA, Perlish JS, Fleischmajer R: Alterations in dermal collagen in ultraviolet irradiated hairless mice. J Invest Dermatol 93:142-146, 1989
41. Smith JG, Davidson EA, Sams WM, Clark RD: Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol 39:347-350, 1962
42. Smulski HS, Wojcicki J: Placebo controlled, double blind trial to determine the efficacy of the Tibetan plant preparation PADMA 28 for intermittent claudication. Altern Ther Health Med 1:44-49, 1995
43. Standeven AM, Johnson AT, Escobar M, Chandraratna RAS: Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol 138:169-175, 1996
44. Stadelmann WK, Digenis AG, Tobin GR: Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176 (Suppl 2A):26s-38s, 1998
45. Strigini L, Ryan T: Wound healing in elderly human skin. Clin Dermatol 14:197-206, 1996
46. Stoll SW, Elder JT: Retinoid regulation of heparin-binding EGF-like growth factor expression in human keratinocytes and skin. Exp Dermatol 7:391-397, 1998
47. Suter M, Richter C: Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation. Redox Rep 5:17-22, 2000
48. Talwar HS, Griffiths CEM, Fisher GJ, Hamilton TA, Voorhees JJ: Reduced type I and type III procollagens in photodamaged adult human skin. J Invest Dermatol 105:285-290, 1995
49. Uitto J, Paul JL, Brockly K, Pearce RH, Clark JG: Elastic fibers in human skin: Quantitation of elastic fibers by computerized digital image analysis and radioimmunoassay of desmosine. Lab Invest 49:499-505, 1983
50. Varani J, Fligiel SEG, Schuger L, Perone P, Inman DR, Griffiths CEM, Voorhees JJ: Effects of all-trans retinoic acid and Ca2+ on human skin in organ culture. Am J Pathol 142:189-198, 1993
51. Varani J, Mitra RS, Gibbs D, Phan SH, Nickoloff BJ, Voorhees JJ: All-frans retinoic acid stimulates extracellular matrix production in growth-inhibited cultured human skin fibroblasts. J Invest Dermatol 794:717-723, 1990a
52. Varani J, Nickoloff BJ, Dixit VM, Mitra RS, Voorhees JJ: All-trans retinoic acid stimulates growth of adult human keratinocytes cultured in growth factor-deficient medium, inhibits production of fibronectin and reduces adhesion. J Invest Dermatol 93:449-454, 1989
53. Varani J, Perone P, Griffiths C, Inman D, Fligiel S, Voorhees J: All-trans retinoic acid stimulates events in organ cultured human skin that underlie repair. J Clin Invest 94:1747-1756, 1994
54. Varani J, Shayevitz J, Perry D, Mitra RS, Nickoloff BJ, Voorhees JJ: Retinoic acid stimulation of human dermal fibroblast proliferation is dependent on suboptimal extracellular Ca2+ concentration. Am. J Pathol 136:1275-1281, 1990b
55. Varani J, Warner RL, Gharaee-Kermani M, et al: Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 114:480-486, 2000
56. Varani J, Zeigler ME, Dame MK, et al: HB-EGF activation of keratinocyte ErbB receptors mediates epidermal hyperplasia following retinoid treatment: A prominent side effect of retinoid therapy. J Invest Dermatol 117:1335-1343, 2001
57. Weiss JS, Ellis CN, Voorhees JJ: Topical tretinoin improves photoaged skin: A double blind, vehicle-controlled study. JAMA 259:527-532, 1988
58. Weseler A, Saller R, Reichling J: Comparative investigation of the antimicrobial activity of PADMA 28 and selected European herbal drugs. Forsch Komplementarmed Klass Naturheilkd 9/6:346-351, 2002
59. Winther K, Kharazmi A, Himmelstrup H, Drabaek H, Mehlsen J: PADMA 28, a botanical compound, decreases the oxidative burst response of monocytes and improves fibrinolysis in patients with stable intermittent claudication. Fibrinolysis 8 (Suppl. 2):47-49, 1994
60. Xiao JH, Feng XW, Peng ZH, Li LA, Chambon P, Voorhees JJ: Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. EMBO J 18:1539-1548, 1999