Effects in post-menopausal women of transdermal estrogen associated with progestin upon the removal from the plasma of a microemulsion that resembles low-density lipoprotein (LDL)

Maturitas

Volumn 50, Issue 4, 2005, Pages 275-281

  Melo, Nilson R ^a   Latrilha, Maria C ^a   Santos, Raul D ^a   Pompei, Luciano M ^a   Maranhão, Raul C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hormone replacement therapy; Lipid emulsions; Menopause

Indexed keywords

CHOLESTEROL OLEATE; ESTRADIOL; ESTROGEN; GESTAGEN; ISOTOPE; LIPID EMULSION; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MEDROXYPROGESTERONE ACETATE;

ARTICLE; CATABOLISM; CHOLESTEROL BLOOD LEVEL; DIET RESTRICTION; FEMALE; HORMONE SUBSTITUTION; HUMAN; MICROEMULSION; POSTMENOPAUSE; PROTEIN BINDING; PROTEIN STRUCTURE;

EID: 14944378293     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2004.05.009     Document Type: Article

References (28)

1. Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science. 232:1986;34-47
2. Handley D.A., Arbeeny C.M., Eder H.A., et al. Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 alpha-ethinylestradiol. J. Cell Biol. 90:1981;778-787
3. Walsh B.W., Schiff I., Rosner B., et al. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N. Eng. J. Med. 325:1991;1196-1204
4. Lobo R.A. Effects of hormonal replacement on lipids and lipoproteins in postmenopausal women. J. Clin. Endocrinol. Metab. 73:1991;925-930
5. Connel E.B. Transdermal estrogen therapy. Postgrad. Med. 101:1997;115-134
6. Karjalainen A., Heikkinen J., Savolainen M.J., et al. Mechanisms regulating LDL metabolism in subjects on peroral and transdermal estrogen replacement therapy. Arterioscler. Thromb. Vasc. Biol. 20:2000;1101-1106
7. Maranhão R.C., Cesar T.B., Pedroso-Mariani S., et al. Metabolic behavior in rats of nonprotein microemulsion resembling low-density lipoprotein. Lipids. 28:1993;691-696
8. Maranhão R.C., Garicochea B., Silva E.L., et al. Plasma kinetics and biodistribution of a lipid emuldion resembling low density lipoprotein in patients with acute leukemia. Cancer Res. 54:1994;4660-4666
9. Maranhão R.C., Roland I.A., Toffoletto O., et al. Plasma kinetic behavior in hyperlipidemic subjects of a lipidic microemulsion that binds to low density lipoprotein receptors. Lipids. 32:1997;627-633
10. Hungria V.T., Latrilha M.C., Rodrigues D.G., et al. Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease. Cancer Chemother. Pharmacol. 53:2004;51-60
11. Ho Y.K., Smith G.L., Brown M.S., Goldstein J.L. Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood. 52:1978;1099-1114
12. Pinto L.B., Wajngarten M., Silva E.L., et al. Plasma kinetics of a cholesterol-rich emulsion in young, middle-aged, and elderly subjects. Lipids. 36(12):2001;1307-1311
13. Ericksson S., Ericksson M., Vitols S., et al. Influence of age on the metabolism of plasma LDL in healthy males. J. Clin. Invest. 87:1991;591-596
14. Santos R.D., Hueb W., Oliveira A.A., et al. Plasma kinetics of a cholesterol-rich emulsion in subjects with or without coronary artery disease. J. Lipid Res. 44(3):2003;464-469
15. Hirata R.D., Hirata M.H., Mesquita C.H., et al. Effects of apolipoprotein B-100 on the metabolism of a lipid microemulsion model in rats. Biochim. Biophys. Acta. 1437(1):1999;53-62
16. The Expert Panel. Summary of the second report of the National Cholesterol Educational Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel II). JAMA 1993;269:3015-23.
17. Friedwald W.T., Levy R.I., Fredrickison D.S. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without the use of preparative ultracentrifuge. Clin. Chem. 18:1972;499-502
18. Ginsburg G.S., Small D.M., Atkinson D. Microemulsions of phospholipids and cholesterol esters: protein-free models of LDL. J. Biol. Chem. 25:1987;8216-8227
19. Matthews C.M.E. The theory of tracer experiments with I-labeled plasma proteins. Phys. Med. Biol. 2:1957;36-42
20. Maranhao R.C., Feres M.C., Martins M.T., et al. Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease. Atherosclerosis. 126(1):1996;15-25
21. Vinagre CGC, Morikawa AT, Alves, et al. Influence of exercise training on LDL metabolism and LDL oxidative process. Atherosclerosis 2002;(Suppl. 3):231.
22. Witztum J.L., Steinberg D. Role of oxidised LDL in atherogenesis. J. Clin. Invest. 8:1991;1785-1792
23. Chisolm G.M., Steinberg D. The oxidative modification hypothesis of atherogenesis: an overview. Free Radic. Biol. Med. 28:2000;1815-1826
24. Kushwaha R.S. Female sex steroid hormones and lipoprotein metabolism. Curr. Opin. Lipidol. 3:1992;167-172
25. Nanjee MN, Kortinik DR, Thomas J, et al. NE. Hormonal determinants of apolipoprotein B,E receptor expression in human liver. Positive association of receptor expression with plasma estrone concentration in middle-aged/eldery women. Biochim Biophys Acta 1990;1046:151-58.
26. De Lignieres B., Basdevant A., Thomas G., et al. Biological effects of estradiol 17 beta in postmenopausal women: oral versus percutaneous administration. J. Clin. Endocrinol. Metab. 62:1986;536-541
27. Goldstein JL, Hobbs H, Brown MS, et al. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease, vol. II. New York: McGraw-Hill; 1995. p. 1281.
28. Godsland I.F. Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertil. Steril. 75:2001;898-915