Recombinant factor VIIa: How safe is the stuff?;Le facteur VIIa recombinant: Jusqu'où le truc est-il sûr?

Canadian Journal of Anesthesia

Volumn 52, Issue 1, 2005, Pages 8-11

  Roberts, Harold R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

BLEEDING DISORDER; BLOOD CLOTTING FACTOR 7 DEFICIENCY; CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG MECHANISM; DRUG MONITORING; DRUG SAFETY; EDITORIAL; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEMOPHILIA; HEMOSTASIS; HUMAN; LUNG EMBOLISM; LUNG HEMORRHAGE; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROTHROMBIN TIME; STROKE; THROMBOCYTE ACTIVATION; THROMBOEMBOLISM; THROMBOGENICITY; THROMBOSIS;

EID: 14944370949     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03018573     Document Type: Editorial

References (7)

1. Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood 2004 August 24 [Epub, ahead of print].
2. Aledort LM. Adverse reactions related to rVIIa? (Letter). Am J Hematol 2001; 67: 213.
3. Pavese P, Bonadona A, Beaubien J, et al. FVIIa corrects the coagulopathy of fulminant hepatic failure but may be associated with thrombosis: a report of four cases. Can J Anesth 2005; 52: 26-9.
4. Abshire T, Kenet G. Recombinant factor VIIa: a review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors. J Thromb Haemost 2004; 2: 899-909.
5. Levi M. Recombinant factor VIIa: a general hemostatic agent? Not yet. J Thromb Haemost 2004; 2: 1695-7.
6. Roberts HR. Recombinant factor VIIa: a general hemostatic agent? Yes. J Thromb Haemost 2004; 2: 1691-4.
7. Gabriel DA, Carr M, Roberts HR. Monitoring coagulation and the clinical effects of recombinant factor VIIa. Semin Hematol 2004; 41(Suppl 1): 20-4.