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Volumn 127, Issue 10, 2005, Pages 3256-3257

Synthesis of the potent immunostimulatory adjuvant QS-21A

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; QS 21A; UNCLASSIFIED DRUG;

EID: 14944364716     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0422007     Document Type: Article
Times cited : (80)

References (23)
  • 5
    • 0035961455 scopus 로고    scopus 로고
    • See, inter alia: (a) Evans, T. G. et al. Vaccine 2001, 19, 2080. (b) Gilewski, T. et al. Proc. Natl. Acad. Sci., U.S.A. 2001, 98, 3270. (c) Krug, L. M.; Ragupathi, G.; Hood, C.; Kris, M. G.; Miller, V. A.; Allen, J. R.; Keding, S. J.; Danishefsky, S. J.; Gomez, J.; Tyson, L.; Pizzo, B.; Baez, V.; Livingston P. O. Clin. Cancer Res. 2004, 10, 6094, and references therein.
    • (2001) Vaccine , vol.19 , pp. 2080
    • Evans, T.G.1
  • 6
    • 0035853030 scopus 로고    scopus 로고
    • See, inter alia: (a) Evans, T. G. et al. Vaccine 2001, 19, 2080. (b) Gilewski, T. et al. Proc. Natl. Acad. Sci., U.S.A. 2001, 98, 3270. (c) Krug, L. M.; Ragupathi, G.; Hood, C.; Kris, M. G.; Miller, V. A.; Allen, J. R.; Keding, S. J.; Danishefsky, S. J.; Gomez, J.; Tyson, L.; Pizzo, B.; Baez, V.; Livingston P. O. Clin. Cancer Res. 2004, 10, 6094, and references therein.
    • (2001) Proc. Natl. Acad. Sci., U.S.A. , vol.98 , pp. 3270
    • Gilewski, T.1
  • 8
    • 14944365136 scopus 로고    scopus 로고
    • note
    • The absolute configurations of the individual monosaccharide constituents within 1 have heretofore only been assumed based on natural abundance.
  • 9
    • 0035859361 scopus 로고    scopus 로고
    • Previous synthetic efforts: (a) Kim, Y.-J.; Gin, D. Y. Org. Lett. 2001, 3, 1801. (b) Zhu, X.; Yu, B.; Hui, Y.; Schmidt, R. R. Eur. J. Org. Chem. 2004, 965.
    • (2001) Org. Lett. , vol.3 , pp. 1801
    • Kim, Y.-J.1    Gin, D.Y.2
  • 17
    • 14944353975 scopus 로고    scopus 로고
    • note
    • See Supporting Information for the preparation of 10, 11 and 13.
  • 23
    • 14944362824 scopus 로고    scopus 로고
    • note
    • 1HNMR, and MS data of synthetic 1 were identical to those of natural 1, obtained by RP-HPLC of Quil A (Accurate Chemical & Scientific Corp.), a Quillaja extract known to contain traces of 1.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.