Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1528-1539

  Imhof, Diana ^a   Wieligmann, Karin ^b   Hampel, Kornelia ^a   Nothmann, Doreen ^a   Zoda, Mohammad S ^a   Schmidt Arras, Dirk ^a   Zacharias, Martin ^c   Böhmer, Frank D ^a   Reissmann, Siegmund ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; ASPARTIC ACID; CARBOXYLIC ACID DERIVATIVE; CYCLOPEPTIDE; GLUTAMIC ACID; GLYCINE; LYSINE; PHENYLALANINE; PHOSPHOPEPTIDE; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 1 INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; TYROSINE KINASE ROS; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME INHIBITION; EVALUATION; MOLECULAR MODEL; PROTEIN DOMAIN;

DRUG DESIGN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PHOSPHOPEPTIDES; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 14944364523     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049151t     Document Type: Article

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