Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

Biological Chemistry

Volumn 386, Issue 1, 2005, Pages 41-52

  Akoachere, Monique ^a   Iozef, Rimma ^a   Rahlfs, Stefan ^a   Deponte, Marcel ^a   Mannervik, Bengt ^b   Creighton, Donald J ^c   Schirmer, Heiner ^d   Becker, Katja ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF MARYLAND   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Drug development; Enzyme inhibition; Glutathione derivatives; Methylglyoxal; Molecular modeling

Indexed keywords

(N HYDROXY N BROMOPHENYLCARBAMOYL)GLUTATHIONE; (N HYDROXY N CHLOROPHENYLCARBAMOYL)GLUTATHIONE; (N HYDROXY N PHENYLCARBAMOYL)GLUTATHIONE; ANTIMALARIAL AGENT; ENZYME INHIBITOR; GLUTATHIONE DERIVATIVE; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTOYLGLUTATHIONE LYASE; PARA BROMOBENZYLGLUTATHIONE; PRODRUG; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; APICOPLAST; ARTICLE; BINDING SITE; CHROMOSOME 12; CHROMOSOME 4; CHROMOSOME 6; CHROMOSOME ANALYSIS; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE OVEREXPRESSION; HOST CELL; HUMAN; METAL BINDING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; SEQUENCE TAGGED SITE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; GENE EXPRESSION REGULATION; GLUTATHIONE; HUMANS; KINETICS; LACTOYLGLUTATHIONE LYASE; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; THIOLESTER HYDROLASES;

PLASMODIUM FALCIPARUM;

EID: 14944354773     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2005.006     Document Type: Article

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