Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion

Critical Care Medicine

Volumn 33, Issue 3, 2005, Pages 645-653

  Bracht, Hendrik ^a   Takala, Jukka ^a   Tenhunen, Jyrki J ^b   Brander, Lukas ^a   Knuesel, Rafael ^a   Merasto Minkkinen, Minna ^b   Jakob, Stephan M ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Blood flow; Cardiac tamponade; Hepatic arterial buffer response; Ischemia; Low flow; Oxygen kinetics

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTICLE; CONTROLLED STUDY; EXTRACORPOREAL OXYGENATION; FEMALE; HEART TAMPONADE; ISCHEMIA; LIVER BLOOD FLOW; MALE; MEDICAL ASSESSMENT; MESENTERY BLOOD VESSEL; MESENTERY ISCHEMIA; MUSCLE PERFUSION; NONHUMAN; OXYGEN CONSUMPTION; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SPECIES COMPARISON; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC VEIN; SWINE; TISSUE OXYGENATION;

ANIMALS; AORTA, ABDOMINAL; CARDIAC TAMPONADE; FEMALE; HEPATIC ARTERY; ISCHEMIA; LIVER; MALE; OXYGEN; OXYGEN CONSUMPTION; RANDOM ALLOCATION; REGIONAL BLOOD FLOW; SPLANCHNIC CIRCULATION; STATISTICS, NONPARAMETRIC; SWINE;

EID: 14944348759     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000156445.59009.49     Document Type: Article

References (36)

1. Schlichting E, Lyberg T: Monitoring of tissue oxygenation in shock: An experimental study in pigs. Crit Care Med 1995; 23:1703-1710
2. Dantzker DR: The gastrointestinal tract. The canary of the body? JAMA 1993; 270:1247-1248
3. Carrico CJ, Meakins JL, Marshall JC, et al: Multiple-organ-failure syndrome. Arch Surg 1986; 121:196-208
4. Dahn MS, Lange P, Lobdell K, et al: Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 1987; 101:69-80
5. Edouard AR, Degremont AC, Duranteau J, et al: Heterogeneous regional vascular responses to simulated transient hypovolemia in man. Intensive Care Med 1994; 20:414-420
6. Bulkley GB, Oshima A, Bailey RW, et al: Control of gastric vascular resistance in cardiogenic shock. Surgery 1985; 98:213-223
7. Mythen MG, Webb AR: Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 1995; 130:423-429
8. Thoren A, Jakob SM, Pradl R, et al: Jejunal and gastric mucosal perfusion versus splanchnic blood flow and metabolism: An observational study on postcardiac surgical patients. Crit Care Med 2000; 28:3649-3654
9. Jakob SM, Tenhunen JJ, Laitinen S, et al: Effects of systemic arterial hypoperfusion on splanchnic hemodynamics and hepatic arterial buffer response in pigs. Am J Physiol Gastrointest Liver Physiol 2001; 280:G819-G827
10. Lautt WW: Mechanism and role of intrinsic regulation of hepatic arterial blood flow: Hepatic arterial buffer response. Am J Physiol 1985; 249:G549-G556
11. Riddez L, Hahn RG, Brismar B, et al: Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers. Crit Care Med 1997; 25:635-640
12. Jakob SM, Tenhunen JJ, Heino A, et al: Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs. Shock 2002; 18:142-147
13. Rowell LB, Blackmon JR, Kenny MA, et al: Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans. Am J Physiol 1984; 247:H251-H258
14. Knuesel R, Jakob SM, Brander L, et al: Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction. Intensive Care Med 2003; 29:2255-2265
15. Jakob SM, Merasto-Minkkinen M, Tenhunen JJ, et al: Prevention of systemic hyperlactatemia during splanchnic ischemia. Shock 2000; 14:123-127
16. Ayuse T, Brienza N, O'Donnell CP, et al: Pressure-flow analysis of portal vein and hepatic artery interactions in porcine liver. Am J Physiol 1994; 267:H1233-H1242
17. Mathie RT, Blumgart LH: The hepatic haemodynamic response to acute portal venous blood flow reductions in the dog. Pflugers Arch 1983; 399:223-227
18. Koizumi M, Matsumoto N, Ueda K: Influences of cardiopulmonary bypass and fentanyl anesthesia on hepatic circulation and oxygen metabolism in beagles. Anesth Analg 1998; 86:1177-1182
19. Beloucif S, Brienza N, Andreoni K, et al: Distinct behavior of portal venous and arterial vascular waterfalls in porcine liver. J Crit Care 1995; 10:104-114
20. Brienza N, Ayuse T, O'Donnell CP, et al: Regional control of venous return: Liver blood flow. Am J Respir Crit Care Med 1995; 152:511-518
21. Lautt WW, McQuaker JE: Maintenance of hepatic arterial blood flow during hemorrhage is mediated by adenosine. Can J Physiol Pharmacol 1989; 67:1023-1028
22. Martinez-Pellus AE, Merino P, Bru M, et al: Can selective digestive decontamination avoid the endotoxemia and cytokine activation promoted by cardiopulmonary bypass? Crit Care Med 1993; 21:1684-1691
23. Oudemans-van Straaten HM, Jansen PG, te VH, Beenakkers IC, et al: Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia. Intensive Care Med 1996; 22:294-300
24. Neuhof C, Wendling J, Dapper F, et al: Endotoxemia and cytokine generation in cardiac surgery in relation to flow mode and duration of cardiopulmonary bypass. Shock 2001; 16(Suppl 1):39-43
25. Bulkley GB, Kvietys PR, Perry MA, et al: Effects of cardiac tamponade on colonic hemodynamics and oxygen uptake. Am J Physiol 1983; 244:G604-G612
26. Zhang H, Smail N, Cabrai A, et al: Hepatosplanchnic blood flow and oxygen extraction capabilities during experimental tamponade: effects of endotoxin. J Surg Res 1999; 81:129-138
27. Saetre T, Gundersen Y, Smiseth OA, et al: Hepatic oxygen metabolism in porcine endotoxemia: The effect of nitric oxide synthase inhibition. Am J Physiol 1998; 275: G1377-G1385
28. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369-1377
29. Dapper F, Neppl H, Wozniak G, et al: Influence of 4 different membrane oxygenators on inflammation-like processes during extracorporeal circulation with pulsatile and non-pulsatile flow. Eur J Cardiothorac Surg 1992; 6:18-24
30. Boeken U, Feindt P, Schulte HD, et al: Elastase release following myocardial ischemia during extracorporeal circulation (ECC) - Marker of ongoing systemic inflammation? Thorac Cardiovasc Surg 2002; 50:136-140
31. Hampton WW, Townsend MC, Schirmer WJ, et al: Effective hepatic blood flow during cardiopulmonary bypass. Arch Surg 1989; 124:458-459
32. Mathie RT: Hepatic blood flow during cardiopulmonary bypass. Crit Care Med 1993; 21:S72-S76
33. Haisjackl M, Birnbaum J, Redlin M, et al: Splanchnic oxygen transport and lactate metabolism during normothermic cardiopulmonary bypass in humans. Anesth Analg 1998; 86:22-27
34. Gardeback M, Settergren G, Brodin LA, et al: Splanchnic blood flow and oxygen uptake during cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2002; 16:308-315
35. Okano N, Hiraoka H, Owada R, et al: Hepatosplanchnic oxygenation is better preserved during mild hypothermic than during normothermic cardiopulmonary bypass. Can J Anaesth 2001; 48:1011-1014
36. Okano N, Miyoshi S, Owada R, et al: Impairment of hepatosplanchnic oxygenation and increase of serum hyaluronate during normothermic and mild hypothermic cardiopulmonary bypass. Anesth Analg 2002; 95:278-286