N-of-1 trials: An opportunity to tailor treatment in individual patients

British Journal of General Practice

Volumn 55, Issue 512, 2005, Pages 171-172

  Madhok, Vishnu ^a   Fahey, Tom ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; DEXAMPHETAMINE; DRUG; IBUPROFEN; METHYLPHENIDATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; QUININE; THEOPHYLLINE;

ATTENTION DEFICIT DISORDER; AWARENESS; BIOEQUIVALENCE; CAREGIVER; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL PRACTICE; CLINICAL STUDY; CLINICAL TRIAL; CONSULTATION; COST EFFECTIVENESS ANALYSIS; DRUG PREFERENCE; DRUG USE; EDITORIAL; GENOME ANALYSIS; HEALTH CARE DELIVERY; HEALTH MAINTENANCE ORGANIZATION; HUMAN; INTERMETHOD COMPARISON; LEG CRAMP; LONG TERM CARE; MEDICAL DECISION MAKING; NIGHT; OSTEOARTHRITIS; PATIENT COMPLIANCE; PATIENT PARTICIPATION; PERCEPTION; PRIMARY MEDICAL CARE; RISK BENEFIT ANALYSIS; SELF REPORT; SIDE EFFECT; STANDARD; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 14944345311     PISSN: 09601643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (12)

1. Guyatt GH, Sackett D, Taylor DW, et al. Determining optimal therapy - randomised trials in individual patients. N Engl J Med 1986; 314: 889-892.
2. Villanueva EV, Wasiak J. N-of-1 trials for making therapy decisions (Protocol) In: The Cochrane Library, Issue 4, 2004.
3. Guyatt GH, Keller JL, Jaeschke R, et al. The n of-1 randomised controlled trial: clinical usefulness. Our three-year experience. Ann Intern Med 1990; 112: 293-299.
4. Larson EB, Ellsworth, Oas. J. Randomised clinical trials in single patients during a 2 year period. JAMA 1993; 270: 2709-2712.
5. Mahon J, Andreas L, Donner A, Wood T. Randomised study of n-of-1 trials versus clinical practice. BMJ 1996; 312: 1069-1074.
6. Guyatt G, Sackett D, Adachi J, et al. A clinician's guide for conducting randomised trials in individual patients. CAMJ 1988; 139: 497-503.
7. Woodfield R, Goodyear-Smith F, Arrol B. N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg. Br J Gen Pract 2005; 55: 181-185.
8. Nikles CJ, Clavarino AM, Del Mar CB. Using n-of-1 trials as a clinical tool to improve prescribing. Br J Gen Pract 2005; 55: 175-180.
9. Wolf CR, Smith G, Smith RL. Science, medicine, and the future: pharmacogenetics. BMJ 2000; 320: 987-990.
10. Rothwell PM, Mehta Z, Howard SC, et al. From subgroups to individuals: general principles and the example of carotid endarterectomy. Lancet 2005; 365: 256-265.
11. Elwyn G, Edwards A, Kinnersley P. Shared decision-making in primary care: the neglected second half of the consultation. Br J Gen Pract 1999; 49: 477-482.
12. Guyatt GH, Haynes RB, Jaeschke RZ, et al. User's guides to the medical literature XXV. Evidence-based medicine: principles for applying the user's guides to patient care. JAMA 2000; 284: 1290-1296.