Influence of ratios of drug to lipid on the characteristics of solid lipid nanoparticles containing mifepristone

Journal of China Pharmaceutical University

Volumn 36, Issue 1, 2005, Pages 22-26

  Hou, Dong Zhi ^a   Xie, Chang Sheng ^a   Zhu, Chang Hong ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Differential scanning calorimetry; Entrapment efficiency; Laser diffractometry; Ratio of drug to lipid; Solid lipid nanoparticles

Indexed keywords

ABORTIVE AGENT; DRUG CARRIER; MIFEPRISTONE; SOLID LIPID NANOPARTICLE;

ARTICLE; CALCULATION; COLLOID; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; HIGH TEMPERATURE PROCEDURES; LASER DIFFRACTION; MEASUREMENT; MELTING POINT; PARTICLE SIZE; PHYSICAL CHEMISTRY; THERMAL ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL;

EID: 14844348837     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Bunjes H, Drechsler M, Koch MHJ. Incorporation of the model drug ubidecarenone into solid lipid nanopaticles. Pharm Res, 2001, 18 (3):287-293.
2. Müller RH, Karsten M, Sven G. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state or the art. Eur J Pharm Biopharm,2000,50(6):161-177.
3. De Vringer. Topical preparation containing a suspension of solid lipid particles. US Patent, 1999, NO.5904932.
4. Westesen K. Particles with modified physicochemical properties, their preparation and uses. US Patent,2000, NO 6197349.
5. Müller RH, Ruge SA. Solid lipid nanoparticles (SLN) for controlled drug delivery. Amsterdam, Harwood academic publishers, 1998. 219-234.
6. Gulati M, Grover M, Singh S. Lipophilic drug derivatives in liposomes. Int J Pharm, 1998, 165(6):129-168.
7. Lander R, Manger W, Scouloudis M. Gaulin homogenization: a mechanistic study. Biotechnol Prog,2000,16(2):80-85.
8. Sjostrom B, Bergenstani B. Preparation of submicron drug particles in lecithin-stabilized o/w emulsions 1 model studies of the precipitation of cholesterylacetate. Int J Pharm,1992,88 5):53-62.
9. Siekmann B, Westesen K. Investigation on solid lipid nanoparticles prepared by precipitation in o/w emulsion. Eur J Pharm Biopharm, 1996,43(2):104-109.
10. Domb AI. Lipospheres for controlled delivery of substances. US Patent 1993, NO. 188837.
11. Sarkar NN. Mifepristone: bioavailability, pharmacokinetics and use-effectiveness. Eur J Obstet Gynecol Reprod Biol, 2002, 101(3): 113-120.
12. Cortesi R, Esposito E, Luca G. Production of lipospheres as carriers for bioactive compounds. Biomaterials, 2002, 23 (7): 2 283-2 294.
13. Westesen K, Siekmann B, Koch MHJ. Investigation on the physical state of lipid nanoparticles by synchroton radiation X-ray diffraction. Int J Pharm, 1993,93(4):189-199.
14. Hou DZ, Xie CS, Huang KJ.The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials, 2003, 24 (4): 1 781-1 786.
15. Yang SC, Zhu JB, Lu Y. Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm Res, 1999,59(2): 299-307.
16. Norden TP, Siekmann B. Physicochemical characterization of a drug-containing phospholipid-stabilised o/w emulsion for intravenous administration. Eur J Pharm Sci,2002,13(4):393-401.
17. Igartua M, Saulnier P, Pech B. Development and characterization of solid lipid nanoparticles loaded with magnetite. Int J Pharm, 2002,233(6):149-157.
18. Cortesi R, Esposito E, Luca G. Production of lipospheres as carriers for bioactive compounds. Biomaterials, 2002, 23 (10): 2 283-2 294.
19. Freitas C, Müller RH. Correlation between long-term stability of solid lipid nanoarticles(SLN)and crystallinity of the lipid phase. Eur J Pharm Biopharm, 1997,47(2):125-132.
20. Müller RH, Dobrucki R, Radomska A. Solid lipid nanoparticles as a new formulation with retinal, Acta Polonica Pharmaceutica-Drug Res, 1999,56(9): 117-120.
21. Siekmann B, Westesen K. Thermoanalysis of the recrystallization process of melt-homogenized glycerid nanoparticles. Colloids Surf B, 1994, 36(2):159-175.
22. Weatesen K, Bunjes H, Koch MHJ. Physicochemical characterization of lipid nanoparticles, and evaluation of their drug loading capacity and sustained release potential. J Control Rel, 1997,48(3):223-236.