Pharmacokinetics of intravenous insulin delivery in humans with type 1 diabetes

Diabetes Technology and Therapeutics

Volumn 7, Issue 1, 2005, Pages 83-93

  Hipszer, Brian ^a,b   Joseph, Jeffrey ^b   Kam, Moshe ^a  

^a Drexel University   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; BLOOD GLUCOSE MONITORING; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; ENERGY INTAKE; EXERCISE TEST; FEMALE; HUMANS; INSULIN; INSULIN INFUSION SYSTEMS; KINETICS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL;

EID: 14844346390     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2005.7.83     Document Type: Conference Paper

References (14)

1. Hirsch IB, Paauw DS, Brunzell J: Inpatient management of adults with diabetes. Diabetes Care 1995;18:870-178.
2. Malmberg KA: Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 1997;314:1512-1515.
3. Furnary AP, Zerr KJ, Grunkemeier GL, Starr A: Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999;67:352-360.
4. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critical ill patients. N Engl J Med 2001;345:1359-1367.
5. Frost DP, Srivastava MC, Jones RH, Nabarro JD, Sonksen PH: The kinetics of insulin metabolism in diabetes mellitus. Postgrad Med J 1973;49(Suppl 7):949-954.
6. Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R: A model of the kinetics of insulin in man. J Clin Invest 1974;53:1481-1492.
7. Tranberg KG, Dencker H: Modeling of plasma disappearance of unlabeled insulin in man. Am J Physiol 1978;235:E577-E585.
8. Home PD, Massi-Benedetti M, Shepherd GA, Hanning I, Alberti KG, Owens DR: A comparison of the activity and disposal of semi-synthetic human insulin and porcine insulin in normal man by the glucose clamp technique. Diabetologia 1982;22:41-45.
9. Kobayashi T, Sawano S, Itoh T, Kosaka K, Hirayama H, Kasuya Y: The pharmacokinetics of insulin after continuous subcutaneous infusion or bolus subcutaneous injection in diabetic patients. Diabetes 1983;32:331-336.
10. Fugleberg S, Kolendorf K, Thorsteinsson B, Bliddal H, Lund B, Bojsen F: The relationship between plasma concentration and plasma disappearance rate of immunoreactive insulin in normal subjects. Diabetologia 1982;22:437-140.
11. Thorsteinsson B, Fugleberg S, Binder C: Kinetics of human and porcine insulins in normal and type I diabetic subjects. Eur J Clin Pharmacol 1987;33:173-178.
12. World Health Organization: WHO Technical Report Series, No. 894: Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation. Geneva: World Health Organization, 2000.
13. Marquardt DW: An algorithm for least-squares estimation of nonlinear parameters. J Soc Ind Appl Math 1963;11:431-441.
14. Thorsteinsson B: Kinetic models for insulin disappearance from plasma in man. Dan Med Bull 1990;37:143-153.