Studies on the stereoselectivity in transdermal permeation and metabolism of ketoprofen prodrugs

Journal of China Pharmaceutical University

Volumn 36, Issue 1, 2005, Pages 18-21

  Zhu, Quan Gang ^a   Hu, Jin Hong ^a   Xi, Wei ^a   Liu, Shao Ming ^a   Sun, Hua Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Ketoprofen; Prodrug; Stereoselectivity; Transdermal

Indexed keywords

GLYCOPHORIN A; KETOPROFEN; PRODRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION; DRUG METABOLISM; DRUG PENETRATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MATHEMATICAL COMPUTING; NONHUMAN; RACEMIC MIXTURE; RAT; SKIN PERMEABILITY; STEADY STATE; STEREOCHEMISTRY;

EID: 14844338586     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Tegeder I, Lotsch J, Schippers MK, et al. Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen. Pharm Res, 2001, 18(7):980-986.
2. Chinese source. (Sun HJ), (Hu JH), (Zhu QG). (Acad J Second Med Coll PLA), 1999,20(6):371-373.
3. Rautio J, Taipale H, Gynther J, et al. In vitro evaluation of acyloxyalkyl esters as demal prodrugs of ketoprofen and naproxen. J Pharm Sci, 1998,87(12): 1622-1628.
4. Bonina FP, Puglia C, Barbuzzi T, et al. In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac. Eur J Pharm Sci,2001,14 2): 123-134.
5. (Yang YJ), (Hou MQ). Chinese source. (Chin J Pharm Anal) 2001, 21(2):97-100.
6. (Zeng LG), (Gong SX), (Xia ZN). Chinese source. (Chin J Pharm Anal), 2002,22(1):74-75.
7. Kommuru TR, Khan MA, Reddy IK. Racemate and enantiomers of ketoprofen: phase diagram, thermodynamic studies, skin permeability, and use of chiral permeation enhancers. J Pharm Sci, 1998, 87 (7):833-840.
8. (Hu JH), (Zhu QG), (Shen Q). Chinese source. (Acta Pharm Sin), 2003,38(10):783-786.