Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro

Acta Tropica

Volumn 93, Issue 3, 2005, Pages 221-231

  Mariga, S T ^a   Gil, J P ^a   Wernsdorfer, W H ^b   Bjorkman A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Amodiaquine; Desethylamodiaquine; Drug interactions; In vitro; Plasmodium falciparum

Indexed keywords

AMODIAQUINE; ARTEMISININ; ATOVAQUONE; DEETHYLAMODIAQUINE; QUININE;

DISEASE CONTROL; MALARIA; METABOLISM; QUININE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SENSITIVITY; NONHUMAN; PLASMODIUM FALCIPARUM; QUANTITATIVE ANALYSIS;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

EID: 14844334573     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2005.01.007     Document Type: Article

References (32)

1. M. Adjuik, P. Agnamey, A. Babiker, S. Borrmann, P. Brasseur, M. Cisse, F. Cobelens, S. Diallo, J.F. Faucher, P. Garner, S. Gikunda, P.G. Kremsner, S. Krishna, B. Lell, M. Loolpapit, P.B. Matsiegui, M.A. Missinou, J. Mwanza, F. Ntoumi, P. Olliaro, P. Osimbo, P. Rezbach, E. Some, and W.R. Taylor Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial Lancet 359 2002 1365 1372
2. H. Alin, A. Björkman, and W.H. Wernsdorfer Synergism of benflumetol and artemether in Plasmodium falciparum Am. J. Trop. Med. Hyg. 61 1999 439 445
3. A. Björkman Quinine-resistant malaria in Africa Trans. R. Soc. Trop. Med. Hyg. 85 1991 138 139
4. P.B. Bloland A contrarian view of malaria therapy policy in Africa Am. J. Trop. Med. Hyg. 68 2003 125 126
5. P. Brasseur, R. Guiguemde, S. Diallo, V. Guiyedi, M. Kombila, P. Ringwald, and P.L. Olliaro Amodiaquine remains effective for treating uncomplicated malaria in west and central Africa Trans. R. Soc. Trop. Med. Hyg. 93 1999 645 650
6. C.J. Canfield, M. Pudney, and W.E. Gutteridge Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro Exp. Parasitol. 80 1995 373 381
7. P.L. Chiodini, C.P. Conlon, D.B. Hutchinson, J.A. Farquhar, A.P. Hall, T.E. Peto, H. Birley, and D.A. Warrell Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria J. Antimicrob. Chemother. 36 1995 1073 1078
8. F.C. Churchill, L.C. Patchen, C.C. Campbell, I.K. Schwartz, P. Nguyen-Dinh, and C.M. Dickinson Amodiaquine as a pro-drug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans Life Sci. 36 1985 53 62
9. W.W. Daniel A Foundation for Analysis in the Health Sciences fifth ed. 1991 John Wiley & Sons Inc New York, N.Y.
10. O. Famin, and H. Ginsburg Differential effects of 4-aminoquinoline- containing antimalarial drugs on hemoglobin digestion in Plasmodium falciparum-infected erythrocytes Biochem. Pharmacol. 63 2002 393 398
11. T. Gordi, D.X. Huong, T.N. Hai, N.T. Nieu, and M. Ashton Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens Antimicrob. Agents Chemother. 46 2002 1026 1031
12. S. Gupta, M.M. Thapar, S.T. Mariga, W.H. Wernsdorfer, and A. Bjorkman Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine Exp. Parasitol. 100 2002 28 35
13. S. Gupta, M.M. Thapar, W.H. Wernsdorfer, and A. Bjorkman In vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum Antimicrob. Agents Chemother. 46 2002 1510 1515
14. J.J. Kessl, B.B. Lange, T. Merbitz-Zahradnik, K. Zwicker, P. Hill, B. Meunier, H. Palsdottir, C. Hunte, S. Meshnick, and B.L. Trumpower Molecular basis for atovaquone binding to the cytochrome bc1 complex J. Biol. Chem. 278 2003 31312 31318
15. F. Laurent, S. Saivin, P. Chretien, J.F. Magnaval, F. Peyron, A. Sqalli, A.E. Tufenkji, Y. Coulais, H. Baba, and G. Campistron Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers Arzneimittelforschung 43 1993 612 616
16. J.T. Litchfield, and F. Wilcoxon A simplified method of evaluating dose-effect experiments J. Pharmacol. Exp. Ther. 96 1949 99 113
17. S. Looareesuwan, C. Viravan, H.K. Webster, D.E. Kyle, D.B. Hutchinson, and C.J. Canfield Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand Am. J. Trop. Med. Hyg. 54 1996 62 66
18. S.R. Meshnick Artemisinin: mechanisms of action, resistance and toxicity Int. J. Parasitol. 32 2002 1655 1660
19. M. Ndounga, and L.K. Basco Rapid clearance of Plasmodium falciparum hyperparasitaemia after oral amodiaquine treatment in patients with uncomplicated malaria Acta Trop. 88 2003 27 32
20. P. Nguyen-Dinh, and W. Trager Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test Am. J. Trop. Med. Hyg. 29 1980 339 342
21. H. Noedl, W.H. Wernsdorfer, S. Krudsood, P. Wilairatana, P. Viriyavejakul, H. Kollaritsch, G. Wiedermann, and S. Looareesuwan In vivo-in vitro model for the assessment of clinically relevant antimalarial cross-resistance Am. J. Trop. Med. Hyg. 65 2001 696 699
22. H. Noedl, W.H. Wernsdorfer, R.S. Miller, and C. Wongsrichanalai Histidine-rich protein II: a novel approach to malaria drug sensitivity testing Antimicrob. Agents Chemother. 46 2002 1658 1664
23. S.A. Omar, I.S. Adagu, D.W. Gump, N.P. Ndaru, and D.C. Warhurst Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area Ann. Trop. Med. Parasitol. 95 2001 661 669
24. E. Pussard, F. Verdier, F. Faurisson, J.M. Scherrmann, J. Le Bras, and M.C. Blayo Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria Eur. J. Clin. Pharmacol. 33 1987 409 414
25. A.B. Sidhu, D. Verdier-Pinard, and D.A. Fidock Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations Science 298 2002 210 213
26. E. Stahel, P. Druilhe, and M. Gentilini Antagonism of chloroquine with other antimalarials Trans. R. Soc. Trop. Med. Hyg. 82 1988 221
27. W.H. Wernsdorfer, G. Wernsdorfer, S. Prajakwong, B. Woitsch, and H. Kollaritsch Activity correlation between artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum from Thailand Mitt. Oesterr. Ges. Tropenmed. Parasitol. 22 2000 87 93
28. N.J. White Antimalarial drug resistance J. Clin. Invest. 113 2004 1084 1092
29. P.A. Winstanley, G. Edwards, M.L.E. Orme, and A.M. Breckenridge The disposition of amodiaquine in man after oral administratrion Br. J. Clin. Pharmacol. 23 1987 1 7
30. P.A. Winstanley, O. Simooya, J.M. Kofi-Ekue, O. Walker, L.A. Salako, G. Edwards, M.L. Orme, and A.M. Breckenridge The disposition of amodiaquine in Zambians and Nigerians with malaria Br. J. Clin. Pharmacol. 29 1990 695 701
31. P.A. Winstanley Coping with malaria in the face of resistance Int. J. Infect. Dis. 6 2002 246 252
32. C. Wongsrichanalai, A.L. Pickard, W.H. Wernsdorfer, and S.R. Meshnick Epidemiology of drug-resistant malaria Lancet Infect. Dis. 4 2002 209 218