Familial Parkinson's disease: Clinical and genetic analysis of four Basque families

Annals of Neurology

Volumn 57, Issue 3, 2005, Pages 365-372

  Paisàn Ruìz, Coro ^a,b   Sàenz, Amets ^b   Lòpez De Munain, Adolfo ^b   Martì, Itxaso ^b   Martìnez Gil, Angel ^c   Martì Massò, Josè F ^b   Pèrez Tur, Jordi ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b HOSPITAL DONOSTIA   (Spain)

^c Hospital Ntra   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 FLUORODOPA F 18; AMANTADINE; ANTIPARKINSON AGENT; BROMOCRIPTINE; CABERGOLINE; GENOMIC DNA; LEVODOPA; PRAMIPEXOLE; SELEGILINE; TRIHEXYPHENIDYL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FAMILIAL DISEASE; FAMILY STUDY; GENETIC LINKAGE; HUMAN; NEUROLOGIC DISEASE; ONSET AGE; PALLIDOTOMY; PARKINSON DISEASE; PEDIGREE ANALYSIS; POLYMERASE CHAIN REACTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SPAIN;

AGED; AGED, 80 AND OVER; BRAIN; FAMILY HEALTH; FEMALE; HAPLOTYPES; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; MOLECULAR BIOLOGY; ODDS RATIO; PARKINSON DISEASE; PEDIGREE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN-SERINE-THREONINE KINASES; SPAIN;

EID: 14844325314     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20391     Document Type: Article

References (21)

1. Polymeropoulos MH, Higgins JJ, Golbe LI, et al. Mapping of a gene for Parkinson's disease to chromosome 4q21-q23. Science 1996;274:1197-1199.
2. Dekker MC, Bonifati V, van Duijn CM. Parkinson's disease: piecing together a genetic jigsaw. Brain 2003;126:1722-1733.
3. Gwinn-Hardy K. Genetics of parkinsonism. Mov Disord 2002; 17:645-656.
4. Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004;304:1158-1160.
5. Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinsons disease. Nature 1998;395:451-452 (Letter).
6. Funayama M, Hasegawa K, Kowa H, et al. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol 2002;51:296-301.
7. Hasegawa K, Kowa H. Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy. Eur Neurol 1997;38(suppl 1):39-43.
8. Zimprich A, Muller-Myhsok B, Farrer M, et al. The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. Am J Hum Genet 2004;74:11-19.
9. Zimprich A, Muller-Myhsok B, Farrer M, et al. Erratum: the PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. Am J Hum Genet 2004;75:534.
10. Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol 1999;56:33-39.
11. Boehnke M. Estimating the power of a proposed linkage study: a practical computer simulation approach. Am J Hum Genet 1986;39:513-527.
12. Ploughman LM, Boehnke M. Estimating the power of a proposed linkage study for a complex genetic trait. Am J Hum Genet 1989;44:543-551.
13. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984;81:3443-3446.
14. Lathrop GM, Lalouel JM. Easy calculations of LOD scores and genetic risks on small computers. Am J Hum Genet 1984;36: 460-465.
15. Cottingham RW Jr, Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993;53: 252-263.
16. Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr. Avoiding recomputation in linkage analysis. Hum Hered 1994;44: 225-237.
17. O'Connell JR, Weeks DE. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nat Genet 1995;11:402-408.
18. Weeks DE, Sobel E, O'Connell JR, Lange K. Computer programs for multilocus haplotyping of general pedigrees. Am J Hum Genet 1995;56:1506-1507.
19. Sobel E, Lange K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 1996;58:1323-1337.
20. Wszolek ZK, Pfeiffer RF, Tsuboi Y, et al. Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology 2004;62:1619-1622.
21. Scott WK, Grubber JM, Conneally PM, et al. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. Am J Hum Genet 2000;66:922-932.