Acute exposure to molinate alters neuroendocrine control of ovulation in the rat

Toxicological Sciences

Volumn 84, Issue 1, 2005, Pages 38-48

  Stoker, Tammy E ^a   Perreault, Sally D ^a   Bremser, Katrine ^a   Marshall, Renee S ^b   Murr, Ashley ^a   Cooper, Ralph L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Estrous cyclicity; Gonadotropin releasing hormone; Luteinizing hormone surge; Molinate; Ovulation; Prolactin

Indexed keywords

ESTRADIOL BENZOATE; GONADORELIN; LUTEINIZING HORMONE; MOLINATE; PROLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; HORMONE DETERMINATION; HORMONE RELEASE; HYPOPHYSIS FUNCTION; HYPOTHALAMUS; IMPLANT; NEUROENDOCRINE DISEASE; NONHUMAN; OOCYTE; OVARIECTOMY; OVIDUCT; OVULATION; PROESTRUS; RAT;

ANIMALS; AZEPINES; BRAIN; CHOLINESTERASES; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG IMPLANTS; ESTROGENS; ESTROUS CYCLE; FEMALE; GONADOTROPIN-RELEASING HORMONE; HERBICIDES; HYPOTHALAMUS; LUTEINIZING HORMONE; NEUROSECRETORY SYSTEMS; NOREPINEPHRINE; OVARIECTOMY; OVULATION; PITUITARY GLAND; PREGNANCY; PROLACTIN; RATS; RATS, LONG-EVANS; THIOCARBAMATES; TIME FACTORS;

EID: 14844310224     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi064     Document Type: Article

References (42)

1. Bielmeier, S. R., Best, D. S., and Narotsky, M. G. (2004), Serum hormone characterization and exogenous hormone rescue of bromodichloromethane-induced pregnancy loss in the F344 rat. Toxicol. Sci. 77, 101-108. Epub 2003 Dec 02.
2. Butcher, R. L. (1976). Pre-ovulatory and post-ovulatory overripeness. Int. J. Gynaecol. Obstet. 14, 105-110.
3. Butcher, R. L., Blue, J. D., and Fugo, N. W. (1969a). Overripeness and the mammalian ova: III. Fetal development at midgestation and at term. Fertil. Steril. 20, 223-231.
4. Butcher, R. L., Blue, J. D., and Fugo, N. W. (1969b). Overripeness and the mammalian ova. 3. Fetal development at midgestation and at term. Fertil. Steril. 20, 223-231.
5. Butcher, R. L., and Fugo, N. W. (1967). Overripeness and the mammalian ova. II. Delayed ovulation and chromosome anomalies. Fertil. Steril. 18, 297-302.
6. Cochran, R. C., Formoli, T. A., Pfeifer, K. F., and Aldous, C. N. (1997), Characterization of risks associated with the use of molinate. Regul. Toxicol. Pharmacol. 25, 146-57.
7. Cooper, R. L., Barrett, M. A., Goldman, J. M., Rehnberg, G. L., McElroy, W. K., and Stoker, T. E. (1994). Pregnancy alterations following xenobiotic-induced delays in ovulation in the female rat. Fundam. Appl. Toxicol. 22, 474-480.
8. Cooper, R. L., Conn, P. M., and Walker, R. F. (1980) Characterization of the LH surge in middle-aged female rats. Biol. Reprod. 23, 611-615.
9. Cooper, R. L., Goldman, J. M., and Rehnberg, G. L. (1986). Neuroendocrine control of reproductive function in the aging female rodent. J. Am. Geriatr. Soc. 34, 735-751.
10. Cooper, R. L., Goldman, J. M., and Stoker, T. E. (1999). Neuroendocrine and reproductive effects of contemporary-use pesticides. Toxicol. Ind. Health 15, 26-36.
11. Cooper, R. L., Stoker, T. E., Goldman, J. M., and Parrish, M. B. (1996). Effect of atrazine on ovarian function in the rat. Reprod. Toxicol. 10, 257-264.
12. Cooper, R. L., Stoker, T. E., Tyrey, L, Goldman, J. M., and McElroy, W. K. (2000). Atrazine disrupts hypothalamic control of pituitary-ovarian function. Toxicol. Sci. 53, 297-307.
13. Costa, L. G., Olibet, G., and Murphy, S. D. (1988) Alpha 2-adrenoceptors as a target for formamidine pesticides: In vitro and in vivo studies in mice. Toxicol. Appl. Pharmacol. 93, 319-328.
14. Eldridge, J. C., Tennant, M. K., Wetzel, L. T., Breckenridge, C. B., and Stevens, J. T. (1994). Factors affecting mammary tumor incidence in chlorotriazine-treated female rats: hormonal properties, dosage, and animal strain. Environ. Health Perspect. 102 Suppl. 11), 29-36.
15. Ellis, M. K., Richardson, A. G., Foster, J. R., Smith, F. M., Widdowson, P. S., Farnworth, M. J., Moore, R. B., Pitts, M. R., and Wickramaratne, G. A. (1998) Molinate: Elucidation of the processes underlying the reproductive effects in the male rat. Toxicol. Appl. Pharmacol. 151(Suppl 1), 22-32.
16. Everett,J. W. (1989). Neurobiology of Reproduction in the Female Rat. Springer-Verlag, New York.
17. Gilles, P.A., and Richter, A.G. (Ciba-Geigy Environmental Health Center) (1989). Two generation reproduction study in female rats with R-4572. ICI Americas Report # T-13218, CDFA Vol. 228-070, #087658.
18. Goldman, J. M., and Cooper, R. L. (1993) Assessment of toxicant-induced alterations in the luteinizing hormone control of ovulation in the rat. In Methods in Toxicology, Vol. III, Part B: Female Reproductive Toxicology (R. E. Chapin and J. Heindel, Eds.), pp. 79-91. Academic Press, Orlando, FL.
19. Goldman, J. M., Cooper, R. L., Edwards, T. L., Rehnberg, G. L., McElroy, W. K., and Hein, J. F. (1991). Suppression of the luteinizing hormone surge by chlordimeform in ovariectomized, steroid-primed female rats. Pharmacol. Toxicol. 68, 131-136.
20. Goldman, J. M., Cooper, R. L., Rehnberg, G. L., Hein, J. F., McElroy, W. K., and Gray, L. E., Jr. (1986). Effects of low subchronic doses of methoxychlor on the rat hypothalamic-pituitary reproductive axis. Toxicol. Appl. Pharmacol. 86, 474-483.
21. Goldman, J. M., Stoker, T. E., Cooper, R. L., McElroy, and W. K., Hein, J. F. (1994). Blockade of ovulation in the rat by the fungicide sodium N-methyldithio-carbamate: Relationship between effects on the luteinizing hormone surge andalterations in hypothalamic catecholamines. Neurotoxicol. Teratol. 16, 257-268.
22. Greenwood, F. C, Hunter, W. M., and Glover, J. S. (1963). The preparation of I-131-labelled human growth hormone of high specific radioactivity. Biochem. J. 89, 114-23.
23. Haavisto, A. M., Pettersson, K., Bergendahl, M., Perheentupa, A., Roser, J. F., and Huhtaniemi, I. (1993). A supersensitive immunofluorometric assay for rat luteinizing hormone. Endocrinology 132, 1687-1691.
24. Harms, P.G., and Ojeda, S.R. (1974). A rapid and simple procedure for chronic cannulation of the rat jugular vein. J. Appl. Physiol. 36, 391-392.
25. Horner, J. M. (1994). Molinate: Acute Neurotoxicity Study in Rats. Unpublished study conducted by Zeneca, submitted to DPA in Study No. CTL/P/4180. DPR Vol. 228-147, No. 129725.
26. Johnson, C. D., and Russell, R. L. (1975). A rapid, simple radiometric assay for cholinesterase suitable for multiple determinations. Anal. Biochem. 64, 229-238.
27. Kalra, S. P., and Kalra, P. S. (1983). Neural regulation of luteinizing hormone secretion in the rat. Endocrinol. Rev. 4, 311-351.
28. Kaur, G., and Kaur, G. (2001). Role of cholinergic and GABAergic neurotransmission in the opioids-mediated GnRH release mechanism of EBP-primed OVX rats. Mol. Cell Biochem. 219, 13-19.
29. Langdale, C., Stoker, T. E., and Cooper, R. L. (2004). Maternal atrazine (ATR) alters hypothalamic dopamine (HYP-DA) and serum prolactin (sPRL) in male pups. Toxicologist Abstracts 566, p. 1-S.
30. Lippman, W., and Lloyd, K. (1971). Effects of tetramethylthiuram disulfide and structurally-related on the dopamine-beta-hydroxylase activity in the rat and hamster. Arch. Int. Pharmacodyn. Ther. 189, 348-357.
31. Peluso, J. J., and Butcher, R. L. (1974). The effect of follicular aging on the ultrastructure of the rat oocyte. Fertil. Steril. 25, 494-502.
32. Perreault, S. D., and Mattson, B. A. (1993). Recovery and morphological evaluation of oocytes, zygotes and preimplantation embryos. In Female Reproductive Toxicology (J. J. Heindel, and R. E. Chapin, Eds, (Methods in Toxicology, vol. 3B), pp. 110-127. Academic Press, San Diego.
33. Scarbrough, K., and Wise, P.M. (1990). Age-related changes in pulsatile luteinizing hormone release precede the transition to estrous acyclicity and depend upon estrous cycle history. Endocrinol., 126, 884-890.
34. Spilman, C., and Harper, M. (1975). Effects of prostaglandins on oviductal motility and egg transport. Gynecol. Invest. 6, 186-205.
35. Stoker, T. E., Cooper, R. L., Goldman, J. M., and Andrews, J. E. (1996) Characterization of pregnancy outcome following thiram-induced ovulatory delay in the female rat. Neurotoxicol. Teratol. 18, 1-6.
36. Stoker, T. E., Goldman, J. M., and Cooper, R. L. (1993). The dithiocarbamate fungicide thiram disrupts the hormonal control of ovulation in the rat. Reprod. Toxicol. 7, 211-218.
37. Stoker, T. E., Goldman, J. M., and Cooper, R. L. (2001). Delayed ovulation and pregnancy outcome: Effect of environmental toxicants on the neuroendocrine control of the ovary. Environ. Toxicol. Pharmacol. 9, 117-129.
38. Stoker, T. E., Jeffay, S. C., Zucker, R., Cooper, R. L. and Perreault, S. D. (2003). Abnormal fertilization is responsible for reduced fecundity following Thiram-induced ovulatory delay in the rat. Biol. Reprod. 68, 2142-2149.
39. Van der Schoot, P. (1976). Changing pro-oestrous surges of luteinizing hormone in ageing 5-day cyclic rats. J. Endocrinol. 69, 287-288.
40. Walker, R. F., Cooper, R. L. and Timiris, P. S. (1980). Constant estrus: Role of rostral hypothalamic monoamines in development of reproductive dysfunction in aging rats. Endocrinology 107, 249-255.
41. Wijayagunawardane, M. P. B. (2001). In vitro regulation of local secretion and contraction of the bovine oviduct: Stimulation by luteinizing hormone, endothelin-1 and prostaglandins, and inhibition by oxytocin. J. Endocrinol. 168, 117-130.
42. Wilkes, M. F., Woollen, B. H., Marsh, J. R., Batten, P. L., and Chester, G. (1993). Biological monitoring for pesticide exposure - The role of human volunteer studies. Int. Arch. Occup. Environ. Health 65(1 Suppl), S189-S192.