Insect sting allergy and venom immunotherapy: A model and a mystery

Journal of Allergy and Clinical Immunology

Volumn 115, Issue 3, 2005, Pages 439-447

  Golden, David B K ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Anaphylaxis; Hymenoptera; Immunotherapy; Insect sting; Venom immunotherapy

Indexed keywords

ALLERGEN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; HYMENOPTERA VENOM; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOMODULATING AGENT; INSECT VENOM;

AGE DISTRIBUTION; DIAGNOSTIC TEST; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; DRUG SENSITIZATION; EDEMA; HIGH RISK PATIENT; HUMAN; HYMENOPTERA; IMMUNOTHERAPY; INSECT ALLERGY; MASTOCYTOSIS; PREDICTION; PRIORITY JOURNAL; RADIOALLERGOSORBENT TEST; RELAPSE; REVIEW; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SIDE EFFECT; SKIN MANIFESTATION; SKIN SENSITIVITY; SKIN TEST; TREATMENT FAILURE;

EID: 14844285804     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.01.005     Document Type: Review

References (79)

1. L.M. Lichtenstein Insect allergy: the state of the art J Allergy Clin Immunol 64 1979 5 12
2. D.B.K. Golden Patterns of anaphylaxis: acute and late phase features of allergic reactions G. Bock J. Goode Anaphylaxis. Novartis Foundation Symposium 257 2004 John Wiley and Sons Chichester (United Kingdom) 101 115
3. J.E. Moffitt, D.B.K. Golden, R.E. Reisman, R. Lee, and R. NIcklas Stinging insect hypersensitivity: a practice parameter update J Allergy Clin Immunol 114 2004 869 886
4. J.H. Barnard Studies of 400 Hymenoptera sting deaths in the United States J Allergy Clin Immunol 52 1973 259 264
5. H.J. Schwartz, C. Sutheimer, B. Gauerke, J.A. Zora, and J.W. Yunginger Venom-specific IgE antibodies in postmortem sera from victims of sudden unexpected death J Allergy Clin Immunol 73 1984 189
6. D.R. Hoffman Fatal reactions to Hymenoptera stings Asthma Allergy Proc 24 2003 1 5
7. R. Benson, and H. Semenov Allergy in its relation to bee sting J Allergy Clin Immunol 1 1930 105 111
8. M.H. Loveless, and W.R. Fackler Wasp venom allergy and immunity Ann Allergy 14 1956 347 366
9. Insect Allergy Committee, American Academy of Allergy Insect sting allergy, cooperative study JAMA 193 1965 115 120
10. H. Brown, and H.S. Bernton Allergy to the Hymenoptera: V. Clinical study of 400 patients Arch Intern Med 125 1970 665 669
11. D.B.K. Golden, J. Langlois, and M.D. Valentine Treatment failures with whole body extract therapy of insect sting allergy JAMA 246 1981 2460 2463
12. L.M. Lichtenstein, M.D. Valentine, and A.K. Sobotka A case for venom treatment in anaphylactic sensitivity to Hymenoptera sting N Engl J Med 290 1974 1223 1227
13. A. Sobotka, M. Valentine, A. Benton, and L. Lichtenstein Allergy to insect stings: I. Diagnosis of IgE-mediated Hymenoptera sensitivity by venom-induced histamine release J Allergy Clin Immunol 53 1974 110 117
14. A.K. Sobotka, N.F.J. Adkinson, M.D. Valentine, and L.M. Lichtenstein Allergy to insect stings, IV: diagnosis by radioallergosorbent tests (RAST) J Immunol 121 1978 2477 2484
15. K.J. Hunt, M.D. Valentine, A.K. Sobotka, and L.M. Lichtenstein Diagnosis of allergy to stinging insects by skin testing with Hymenoptera venoms Ann Intern Med 85 1976 56 59
16. K.J. Hunt, M.D. Valentine, A.K. Sobotka, A.W. Benton, F.J. Amodio, and L.M. Lichtenstein A controlled trial of immunotherapy in insect hypersensitivity N Engl J Med 299 1978 157 161
17. P. Smith, A. Kagey-Sobotka, E.R. Bleecker, R. Traystman, A.P. Kaplan, and H. Gralnick Physiologic manifestations of human anaphylaxis J Clin Invest 66 1980 1072 1080
18. T.M. Freeman, R. Hyghlander, A. Ortiz, and M.E. Martin Imported fire ant immunotherapy: effectiveness of whole body extracts J Allergy Clin Immunol 90 1992 210 215
19. Y.S. Cho, Y.M. Lee, and C.K. Lee Prevalence of Pachycondyla chinensis venom allergy in an ant infested area in Korea J Allergy Clin Immunol 110 2002 54 57
20. S.G. Brown, R.W. Franks, B.A. Baldo, and R.J. Heddle Prevalence, severity and natural history of jack jumper ant venom allergy in Tasmania J Allergy Clin Immunol 111 2003 187 192
21. J.M. Tracy, J.G. Demain, and J.M. Quinn The natural history of exposure to the imported fire ant J Allergy Clin Immunol 95 1995 824 828
22. D.R. Hoffman Hymenoptera venoms: composition, standardization, stability M.I. Levine R.F. Lockey Monograph on insect allergy 4th ed. 2004 American Academy of Allergy Asthma and Immunology Milwaukee (WI) 37 53
23. T.P. King, S.Y. Jim, R.I. Monsalve, A. Kagey-Sobotka, and L.M. Lichtenstein Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s J Immunol 166 2001 6057 6065
24. U.R. Muller Recombinant Hymenoptera venom allergens Allergy 57 2002 570 576
25. D.B.K. Golden, D.G. Marsh, A. Kagey-Sobotka, B.I. Addison, L. Freidhoff, and M. Szklo Epidemiology of insect venom sensitivity JAMA 262 1989 240 244
26. D.B.K. Golden, D.G. Marsh, L.R. Freidhoff, K.A. Kwiterovich, B. Addison, and A. Kagey-Sobotka Natural history of Hymenoptera venom sensitivity in adults J Allergy Clin Immunol 100 1997 760 766
27. J. Day, D. Buckeridge, and A. Welsh Risk assessment in determining systemic reactivity to honeybee stings in sting-threatened individuals J Allergy Clin Immunol 93 1994 691 705
28. R.E. Reisman Natural history of insect sting allergy: relationship of severity of symptoms of initial sting anaphylaxis to re-sting reactions J Allergy Clin Immunol 90 1992 335 339
29. P.G. vanderLinden, C.E. Hack, A. Struyvenberg, and J.K. vanderZwan Insect-sting challenge in 324 subjects with a previous anaphylactic reaction: current criteria for insect-venom hypersensitivity do not predict the occurrence and the severity of anaphylaxis J Allergy Clin Immunol 94 1994 151 159
30. K.C. Schuberth, L.M. Lichtenstein, A. Kagey-Sobotka, M. Szklo, K.A. Kwiterovich, and M.D. Valentine An epidemiologic study of insect allergy in children. I. Characteristics of the disease J Pediatr 100 1982 546 551
31. M.D. Valentine, K.C. Schuberth, A. Kagey-Sobotka, D.F. Graft, K.A. Kwiterovich, and M. Szklo The value of immunotherapy with venom in children with allergy to insect stings N Engl J Med 323 1990 1601 1603
32. D.B.K. Golden, A. Kagey-Sobotka, P.S. Norman, R.G. Hamilton, and L.M. Lichtenstein Outcomes of allergy to insect stings in children with and without venom immunotherapy N Engl J Med 351 2004 668 674
33. D.B.K. Golden, A. Kagey-Sobotka, P.S. Norman, and L.M. Lichtenstein Sting Challenge Trial I: spectrum of a population with insect sting allergy [abstract] J Allergy Clin Immunol 101 suppl 1998 S159
34. U. Muller, A. Helbling, and E. Berchtold Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety J Allergy Clin Immunol 89 1992 529 535
35. P.M. Mauriello, S.H. Barde, J.W. Georgitis, and R.E. Reisman Natural history of large local reactions from stinging insects J Allergy Clin Immunol 74 1984 494 498
36. D.F. Graft, K.C. Schuberth, A. Kagey-Sobotka, K.A. Kwiterovich, Y. Niv, and L.M. Lichtenstein A Prospective study of the natural history of large local reactions following Hymenoptera stings in children J Pediatr 104 1984 664 668
37. H.J. Schwartz, R.F. Lockey, A.L. Sheffer, J. Parrino, W.W. Busse, and J.W. Yunginger A multicenter study on skin test reactivity of human volunteers to venom as compared with whole body Hymenoptera antigens J Allergy Clin Immunol 67 1981 81 85
38. W. Hemmer, M. Frocke, K. Kolarich, I.B.H. Wilson, F. Altmann, and S. Wohrl Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging insect allergy J Allergy Clin Immunol 108 2001 1045 1052
39. D.B.K. Golden, A. Kagey-Sobotka, R.G. Hamilton, P.S. Norman, and L.M. Lichtenstein Insect allergy with negative venom skin tests J Allergy Clin Immunol 107 2001 897 901
40. M. Fricker, L. Helbling, L. Schwartz, and U. Muller Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients J Allergy Clin Immunol 100 1997 11 15
41. B.R. Paull, T.H. Coghlan, and S.B. Vinson Fire ant venom hypersensitivity. I. Comparison of fire ant venom and whole body extract in the diagnosis of fire ant allergy J Allergy Clin Immunol 71 1983 448 453
42. J. Day A comparison of venom concentrations of 0.1 mcg/ml and 1.0 mcg/ml as indicator of sensitivity to honeybee stings [abstract] J Allergy Clin Immunol 77 1986 142
43. D.B.K. Golden, A. Kagey-Sobotka, and R.G. Hamilton Dialyzed venom improves sensitivity of skin tests in yellow jacket allergic patients [abstract] J Allergy Clin Immunol 107 suppl 2001 S222
44. R.E. Reisman Intentional diagnostic insect sting challenges: a medical and ethical issue [letter] J Allergy Clin Immunol 91 1993 1100
45. H.H. Franken, A.E.J. Dubois, H.J. Minkema, S. vanderHeide, and J.G.R. deMonchy Lack of reproducibility of a single negative sting challenge response in the assessment of anaphylactic risk in patients with suspected yellow jacket hypersensitivity J Allergy Clin Immunol 93 1994 431 436
46. J. Sainte-Laudy, A. Sabbah, and M. Drouet Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release Clin Exp Allergy 30 2000 1166 1171
47. B. Eberlein-Konig, J. Rakoski, H. Behrendt, and J. Ring Use of CD63 expression as marker of in vitro basophil activation in identifying insect venom allergy J Investig Allergol Clin Immunol 14 2004 10 16
48. R.G. Hamilton Diagnostic methods for insect sting allergy Curr Opin Allergy Clin Immunol 4 2004 297 306
49. J.N.G. Oude-Elberink, J.G.R. deMonchy, S. vanderHeide, G.H. Guyatt, and A.E.J. Dubois Venom immunotherapy improves health-related quality of life in yellow jacket allergic patients J Allergy Clin Immunol 110 2002 174 182
50. R.H. Hamilton, J.A. Wisenauer, D.B.K. Golden, M.D. Valentine, and N.F. Adkinson Selection of Hymenoptera venoms for immunotherapy based on patients' IgE antibody cross-reactivity J Allergy Clin Immunol 92 1993 651 659
51. J. Oude-Elberink, J. deMonchy, J. Kors, J. vanDoormaal, and A. Dubois Fatal anaphylaxis after a yellow jacket sting despite venom immunotherapy in two patients with mastocytosis J Allergy Clin Immunol 99 1997 153 154
52. D.B.K. Golden, A. Kagey-Sobotka, M.D. Valentine, and L.M. Lichtenstein Dose dependence of Hymenoptera venom immunotherapy J Allergy Clin Immunol 67 1981 370 374
53. J.W. Yunginger, M.E. Dahlberg, R.T. Jones, J.L. Parker, and T.L. Carey Diagnostic and therapeutic importance of individual honeybee venom allergens [abstract] J Allergy Clin Immunol 69 1982 139
54. F. Rueff, A. Wenderoth, and B. Przybilla Patients still reacting to a sting challenge while receiving conventional Hymenoptera venom immunotherapy are protected by increased venom doses J Allergy Clin Immunol 108 2001 1027 1032
55. D.B.K. Golden, M.D. Valentine, A. Kagey-Sobotka, and L.M. Lichtenstein Regimens of Hymenoptera venom immunotherapy Ann Intern Med 92 1980 620 624
56. J.A. Bernstein, S.L. Kagan, D.I. Bernstein, and I.L. Bernstein Rapid venom immunotherapy is safe for routine use in the treatment of patients with Hymenoptera anaphylaxis Ann Allergy 73 1994 423 428
57. J. Birnbaum, D. Charpin, and D. Vervloet Rapid Hymenoptera venom immunotherapy: comparative safety of three protocols Clin Exp Allergy 23 1993 226 230
58. J.W. Yunginger, B.R. Paull, R.T. Jones, and P.J. Santrach Rush venom immunotherapy program for honeybee sting sensitivity J Allergy Clin Immunol 63 1979 340 347
59. C.A. Akdis, T. Blesken, and M. Akdis Role of interleukin 10 in specific immunotherapy J Clin Invest 102 1998 98 106
60. J. Bousquet, J. Knani, and G. Velasquez Evolution of sensitivity to Hymenoptera venom in 200 allergic patients followed for up to 3 years J Allergy Clin Immunol 84 1989 944 950
61. S.M. McHugh, J. Deighton, A.G. Stewart, and P. Ewan Bee venom immunotherapy induces a shift in cytokine responses from a TH2 to a TH1 dominant pattern: comparison of rush and conventional immunotherapy Clin Exp Allergy 25 1995 828 838
62. R.F. Lockey, P.C. Turkeltaub, E.S. Olive, J.M. Hubbard, I.A. Baird-Warren, and S.C. Bukantz The Hymenoptera venom study III: safety of venom immunotherapy J Allergy Clin Immunol 86 1990 775 780
63. A. Goldberg, and R. Confino-Cohen Maintenance venom immunotherapy administered at 3-month intervals is both safe and efficacious J Allergy Clin Immunol 107 2001 902 906
64. D.F. Graft, D.B.K. Golden, R.E. Reisman, M.D. Valentine, and J.W. Yunginger The discontinuation of Hymenoptera venom immunotherapy. Report from the Committee on Insects of the American Academy of Allergy Asthma and Immunology J Allergy Clin Immunol 101 1998 573 575
65. R.E. Reisman, and R. Lantner Further observations of stopping venom immunotherapy: comparison of patients stopped because of a fall in serum venom-specific IgE to insignificant levels with patients stopped prematurely by self-choice J Allergy Clin Immunol 83 1989 1049 1054
66. U. Muller, E. Berchtold, and A. Helbling Honeybee venom allergy: results of a sting challenge 1 year after stopping venom immunotherapy in 86 patients J Allergy Clin Immunol 87 1991 702 709
67. R. Urbanek, J. Forster, and W. Kuhn Discontinuation of bee venom immunotherapy in children and adolescents J Pediatr 107 1985 367 371
68. H.K. vanHalteren, P.W.G. vanderLinden, J.A. Burgers, and A.K.M. Bartelink Discontinuation of yellow jacket venom immunotherapy: follow-up of 75 patients by means of deliberate sting challenge J Allergy Clin Immunol 100 1997 767 770
69. D.B.K. Golden, K.A. Kwiterovich, B.A. Addison, A. Kagey-Sobotka, and L.M. Lichtenstein Discontinuing venom immunotherapy: extended observations J Allergy Clin Immunol 101 1998 298 305
70. D.B.K. Golden, A. Kagey-Sobotka, and L.M. Lichtenstein Survey of patients after discontinuing venom immunotherapy J Allergy Clin Immunol 105 2000 385 390
71. E. Lerch, and U. Muller Long-term protection after stopping venom immunotherapy J Allergy Clin Immunol 101 1998 606 612
72. R.E. Reisman Duration of venom immunotherapy: Relationship to the severity of symptoms of initial insect sting anaphylaxis J Allergy Clin Immunol 92 1993 831 836
73. M.U. Keating, A. Kagey-Sobotka, R.G. Hamilton, and J.W. Yunginger Clinical and immunologic follow-up of patients who stop venom immunotherapy J Allergy Clin Immunol 88 1991 339 348
74. M.H. Lessof, A.K. Sobotka, and L.M. Lichtenstein Effects of passive antibody in bee venom anaphylaxis Johns Hopkins Med J 142 1978 1 7
75. U.R. Muller, T. Morris, M. Bischof, H. Friedli, and F. Skarvil Combined active and passive immunotherapy in honeybee-sting allergy J Allergy Clin Immunol 78 1986 115 122
76. D.B.K. Golden, I.D. Lawrence, A. Kagey-Sobotka, M.D. Valentine, and L.M. Lichtenstein Clinical correlation of the venom-specific IgG antibody level during maintenance venom immunotherapy J Allergy Clin Immunol 90 1992 386 393
77. M. Jutel, W.J. Pichler, D. Skrbic, A. Urwyler, C. Dahinden, and U.R. Muller Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-g secretion in specific allergen stimulated T cell cultures J Immunol 154 1995 4187 4194
78. S. Konno, D.B.K. Golden, J. Schroeder, T.P. King, R.G. Hamilton, and P.S. Creticos Osteopontin: a potential biomarker for successful allergen immunotherapy [abstract] J Allergy Clin Immunol 113 suppl 2004 S215
79. P.A. Wachholz, and S.R. Durham Mechanisms of immunotherapy: IgG revisited Curr Opin Allergy Clin Immunol 4 2004 313 318