Drug loading and elution from a phosphorylcholine polymer-coated coronary stent does not affect long-term stability of the coating in vivo

Bio-Medical Materials and Engineering

Volumn 14, Issue 4, 2004, Pages 355-370

  Lewis, Andrew L ^a   Willis, Sean L ^a   Small, Sharon A ^a   Hunt, Stuart R ^a   O'Byrne, Vincent ^a   Stratford, Peter W ^a  

^a BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

Coronary stent; Drug delivery; in vivo stability; Phosphorylcholine

Indexed keywords

ATOMIC FORCE MICROSCOPY; CELL IMMOBILIZATION; MEDICAL IMAGING; MICROSCOPIC EXAMINATION; ORGANIC COMPOUNDS; PHARMACOKINETICS; POLYMERS; SCANNING ELECTRON MICROSCOPY; TISSUE;

CORONARY STENT; DRUG LOADING; DRUG RELASES; PHOSPHORYLCHOLINE (PC);

DRUG PRODUCTS;

BATIMASTAT; CARBON 14; PHOSPHORYLCHOLINE; POLYMER; BIOMATERIAL; DRUG DERIVATIVE; PHENYLALANINE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ATOMIC FORCE MICROSCOPY; CELL MIGRATION; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY; CORONARY STENT; DRUG DISTRIBUTION; DRUG ELUTING STENT; DRUG RELEASE; DRUG STABILITY; ENDOTHELIUM CELL; EXPLANT; FILM COATING; ILIAC BONE; IMPLANTATION; INFRARED SPECTROSCOPY; MEDICAL ASSESSMENT; NONHUMAN; PRIORITY JOURNAL; RABBIT; REFLECTOMETRY; SAMPLE; SCANNING ELECTRON MICROSCOPY; SWINE; THICKNESS; ANIMAL; ARTICLE; BLOOD VESSEL PROSTHESIS; CHEMISTRY; COMPARATIVE STUDY; CORONARY BLOOD VESSEL; CYTOLOGY; DRUG EFFECT; DRUG IMPLANT; EVALUATION; IMPLANT; MATERIALS TESTING; METABOLISM; STENT;

ORYCTOLAGUS CUNICULUS; SUIDAE;

ANIMALS; BLOOD VESSEL PROSTHESIS; COATED MATERIALS, BIOCOMPATIBLE; CORONARY VESSELS; DRUG IMPLANTS; DRUG STABILITY; IMPLANTS, EXPERIMENTAL; MATERIALS TESTING; PHENYLALANINE; PHOSPHORYLCHOLINE; STENTS; SWINE; THIOPHENES;

EID: 14744305522     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. J.A. Bittl, Advances in coronary angioplasty, N. Eng. J. Med. 335 (1996), 1290-1302.
2. P.W. Serruys, F. Unger, B.A. van Hout et al., The ARTS study (Arterial Revascularization Therapies Study), Semin. Interven. Cardiol. 4 (1999), 209-219.
3. Drug eluting stents, in: Handbook of Coronary Stents, P.W. Serruys, B.J. Rensing, eds, Martin Dunitz, London, 2002, pp. 285-366.
4. J.E. Sousa, M.A. Costa, A.G. Sousa et al., Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries, Circulation 107 (2003), 381-383.
5. E. Grube, S. Silber, K.E. Hauptmann, R. Mueller, L. Buellesfeld, U. Gerckens and M.E. Russell, TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions, Circulation 107 (2003), 38-42.
6. R. Waksman, Late thrombosis after radiation, Circulation 100 (1999), 780-782.
7. S. Silber, C. Brockhoff, R. Doerr, A. Mügge, I. Krischke, P. van Rottkay, T. Meinertz, The German IST-registry: need of one year of clopidogrel to avoid late stent thrombosis, J. Am. Coll. Cardiol. 37 (2001), 82A.
8. E. Grube, L. Bullesfeld, Initial experience with paclitaxel-coated stents, J. Interv. Cardiol. 15 (2002), 471-475.
9. T. Peng, P. Gibula, K. Yao and M.F.A. Goosen, Role of polymers in improving results from stenting in coronary arteries, Biomaterials 17 (1996), 685-694.
10. O.F. Bertrand, R. Sipehia, R. Mongrain et al., Biocompatibility aspects of new stent technology, JACC 32 (1998), 562-571.
11. J.E. Sousa, M.A. Costa, A. Abizaid et al., Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study, Circulation 103 (2001), 801-809.
12. A.L. Lewis, L.A. Tolhurst and P.W. Stratford, Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation, Biomaterials 23 (2002), 1697-1706.
13. A.L. Lewis, J.D. Furze, S. Small, J.D. Robertson, B.J. Higgins, A.S. Taylor and D.R. Ricci, Long-term stability of a coronary stent coating post-implantation J. Biomed. Mater. Res. Appl. Biomat. 63 (2002), 699-705.
14. J. Armstrong, J. Gunn, N. Arnold, N. Malik, K.H. Chan, T. Vick, P. Stratford, D.C. Cumberland and C.M. Holt, Angiopeptin-eluting stents: observations in human vessels and pig coronary arteries, J. Invasive Cardiol. 14 (2002), 230-238.
15. I. De Scheerder, Chapter 2, Anti-inflammatory approach to restenosis, in: The Restenosis Matrix. Restenosis: Multiple Strategies for Stent Drug Delivery, M.T. Rothman, ed., Remedica, London, 2001, pp. 1, 12-31.
16. X. Lui, Y. Huang, I. De Scheerder, S. Li, E. Verbeken, L. Wang, Local methylprednisolone delivery using a BiodivYsio phosphorylcholine coated drug delivery stent reduces inflammation and neointimal hyperplasia in a porcine coronary stent model, Circulation 106(Suppl.) (2002), II357.
17. G. New, J.W. Moses, G.S. Roubin, M.B. Leon, A. Colombo, S.S. Iyer, F.O. Tio, R. Mehran and N. Kipshidze, Estrogen-eluting, phosphorylcholine-coated stent implantation is associated with reduced neointimal formation but no delay in vascular repair in a porcine coronary model, Catheter Cardiovasc. Interv. 57 (2002), 266-271.
18. A.L. Lewis, A.C.M. Collias, T.A. Vick, R.R. Palmer, R. Bushby, S.L. Willis, A.S. Taylor, P.W. Stratford, G. Leclerc, M. Laflamme and M. Bouchard, Local delivery of batimastat from a PC-coated stent reduces neointimal hyperplasia in a porcine coronary model, Abstract from the 7th Europ Symposium on Controlled Drug Delivery, 3-5 April, Noordwijk aan Zee, Netherlands, 2002, p. 140.
19. R.S. Schwartz, S.E. Burke, S. Chen, N.A. Chronos, K. Cromack, K.A. Robinson and P. Tarcha, Marked neointimal inhibition from a drug eluting stent: Effects of local ABT-578 in the porcine coronary model, Circulation 106(Suppl.) (2002), II448-II449.
20. I. Descheerder, Study of Anti-restenosis with BiodiviYsio Dexamethasone-eluting Stent, presented at the TCT, Washington, USA, 2002.
21. J.E. Sousa, A. Abizaid, A.S. Abizaid, G. New et al., Estradiol-eluting BiodivYsio stent to prevent restenosis: A pilot feasibility and safety study, Am. J. Cardiol. 90(Suppl.) (2002), 6A, 6H.
22. B. Chevalier and I. De Scheerder, First in man safety study of batimastat stent: Effect on restenosis, Circulation 106(Suppl.) (2002), II520.
23. D.C. Cumberland and U. Sigwart, The BiodivYsio AS, OC and SV stent range with PC Technology, in: Handbook of Coronary Stents, P.W. Serruys and B.J. Rensing, eds, Martin Dunitz, London, 2002, pp. 29-38.
24. A.L Lewis and P.W. Stratford, PC-coated stents, J. Long-Term Effects Med Implants 12 (2002), 231-250.
25. A.L. Lewis, Z.L. Cumming, H. Goreish, L.C. Kirkwood, L.A. Tolhurst and P.W. Stratford, Crosslinkable coatings from phosphorylcholine-based polymers, Biomaterials 22 (2001), 99-111.
26. D.M. Whelan, W.J. van der Giessen, S.C. Krabbendam, E.A. van Vliet, O.D. Verdouw, P.W. Serruys and H.M.M van Beusekom, Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries, Heart 83 (2000), 338-345.
27. A.L. Lewis, T.A. Vick, A.M.C. Collias, L.G. Hughes, R.R. Palmer, S.W. Leppard, J.D. Furze, A.S. Taylor and P.W. Stratford, Phosphorylcholine-based polymers for stent drug delivery, J. Mater. Sci.: Mater. Med, 12 (2001), 865-870.
28. A.L. Lewis and T.A. Vick, Site-specific drug delivery from coronary stents, Drug Del. Systems Sci. 1 (2001), 65-71.
29. J. Berwick, M. Davies, S. Allen, C. Roberts, P. Williams S. Tendler, A. Lewis and V. O'Byrne, Assessment of dexamethasone uptake by a cross-linkable biomimetic hydrogel, abstract #89, CRS Winter Symposia & 11th International Symposium on Recent Advances in Drug Delivery Systems, March 3-6, 2003, Salt Lake City, Utah.