Effects of flavonoids extrated from Astragalus complanatus on liver fibrosis induced by CCl4 and serum levels of IFN-γ and TGF-β1 in rats

Chinese Pharmaceutical Journal

Volumn 39, Issue 12, 2004, Pages 910-912

  Liu, Chun Yu ^a   Gu, Zhen Lun ^a   Zhang, Ke Ping ^a   Chou, Wen Hsien ^b   Kwork, Chi Yi ^b  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b Health Care Ltd   (Hong Kong)

Author keywords

Astragalus complanatus; Flavonoids; IFN ; Liver fibrosis; TGF 1

Indexed keywords

CONCENTRATION (PROCESS); LIVING SYSTEMS STUDIES; SEED; TISSUE;

ASTRAGALUS COMPLANATUS; LIVER FIBROSIS; SERUM;

BIOLOGICAL ORGANS;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ASTRAGALUS COMPLANATUS EXTRACT; BILIRUBIN; CARBON TETRACHLORIDE; COLCHICINE; FLAVONOID; GAMMA INTERFERON; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS COMPLANATUS; ASTRAGALUS PLANT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; HISTOPATHOLOGY; LIVER FIBROSIS; MICROSCOPY; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME;

FLAVONOIDS; ORGANELLES; PLANT TISSUES; SEEDS;

EID: 14744303231     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Friedman SL. Closing in on the signals of hepatic fibrosis [J]. Gatroenterology, 1997, 112: 1406.
2. Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells[J]. liver, 1998, 18:2.
3. Castilla A, Prieto J, Fausto N. Transforming growth factors beta 1 and alpha in ehronic licer diease. Effects of interferon alpha therapy[J]. N Engl J Med, 1991, 324: 933.
4. Gressner AM, Bachem MG. Molecular of liver fibrogenesis - a homage to the role of activated fat-storage cells[J]. Digestion, 1995, 56: 335.
5. Muriel P, Castro V. Dose-response studies of interferon-alpha 2b on liver fibrosis and cholestasis induced by biliary obstruction in rats[J]. Pharmacology, 1997, 54(4): 179.