Use of the progesterone receptor antagonist RU 486 to identify novel progesterone receptor-regulated pathways in implantation

Seminars in Reproductive Medicine

Volumn 23, Issue 1, 2005, Pages 38-45

  Bagchi, Indrani C ^a   Li, Quanxi ^a   Cheon, Yong Pil ^a   Mantena, Srinivasa Raju ^a   Kannan, Athilakshmi ^a   Bagchi, Milan K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Antiprogestin RU 486; Implantation; Progesterone; Receptor

Indexed keywords

AMPHIREGULIN; ANTIGESTAGEN; CALCITONIN; CELL ADHESION MOLECULE; CYTOSKELETON PROTEIN; FOLLISTATIN; GROWTH FACTOR; LEUKOCYTE ENZYME; LIPOXYGENASE; MESSENGER RNA; PEPTIDE HORMONE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROENKEPHALIN; PROTEINASE INHIBITOR; SOMATOMEDIN BINDING PROTEIN 3; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CLUSTER ANALYSIS; DECIDUALIZATION; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; NIDATION; NONHUMAN; PREGNANCY; RECEPTOR BINDING; REVIEW; UPREGULATION; UTERUS;

ANIMALS; DECIDUA; EMBRYO IMPLANTATION; FEMALE; GENE EXPRESSION REGULATION; HORMONE ANTAGONISTS; MIFEPRISTONE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGESTERONE; RECEPTORS, PROGESTERONE; UP-REGULATION; UTERUS;

EID: 14744301710     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-864032     Document Type: Review

References (57)

1. Psychoyos A. Endocrine control of egg implantation. In: Greep RO, Astwood EG, eds. Handbook of Physiology. Washington, DC: American Physiological Society; 1973:187-215
2. Yoshinaga K. Uterine receptivity for blastocyst implantation. Ann N Y Acad Sci 1988;541:424-431
3. Parr MB, Parr EL. The implantation reaction. In: Wynn RM, Jollie WP, eds. Biology of the Uterus. New York: Plenum Press; 1989:233-277
4. Weitlauf HM. Biology of implantation. In: Knobil E, Neill JD, eds. The Physiology of Reproduction, New York: Raven Press; 1994:391-440
5. Carson DD, Bagchi I, Dey SK, et al. Embryo implantation (review). Dev Biol 2000;223:217-237
6. Paria BC, Huet-Hudson YM, Dey SK. Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus. Proc Natl Acad Sci USA 1993;90:10159-10162
7. Psychoyos A. Uterine receptivity for nidation. Ann N Y Acad Sci 1986;476:36-42
8. Psychoyos A. Hormonal control of uterine receptivity for nidation. J Reprod Fertil Suppl 1976;25:17-28
9. Yoshinaga K. Inhibition of implantation by advancement of uterine sensitivity and refractoriness in blastocyst-endometrium relationships. In: Leroy F, Finn CA, Psychoyos A, Hubinot PO, eds. Progress in Reproductive Biology 7. Basel: Karger; 1980:189-199
10. Finn CA. The implantation reaction. In: Wynn RM, ed. Biology of the Uterus. New York: Plenum Press; 1977:246-308
11. DeFeo VJ. Decidualization. In: Wynn RM, ed. Cellular biology of the uterus. Amsterdam: North Holland; 1967:191-290
12. Cross JC, Werb Z, Fisher SJ. Implantation and the placenta: key pieces of the developmental puzzle. Science 1994;266:1508-1518
13. Irwin JC, Giudice L. Decidua. In: Knobil E, Neill JD, eds. Encyclopedia of Reproduction. Academic Press; 1999:823-835
14. Gu Y, Gibori G. Deciduoma. In: Knobil E, Neill JD, eds. Encyclopedia of Reproduction. San Diego, CA: Academic Press; 1999:836-842
15. Kirby DRS. The invasiveness of the trophoblast. In: Park W, ed. The early Conceptus, Normal and Abnormal. University of St. Andrew Press; 1965:68-74
16. Tsai M-J, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994;63:451-486
17. Lydon JP, DeMayo FJ, Funk CR, et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 1995;9:2266-2278
18. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988;240:889-895
19. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: overview the second decade. Cell 1995;83:835-839
20. Lessey BA. Two pathways of progesterone action in the human endometrium: implications for implantation and contraception. Steroids 2003;68:809-815
21. Okulicz WC, Ace CI, Torres MS. Gene expression in the rhesus monkey endometrium: differential display and laser capture microdissection. Front Biosci 2003;8:d551-d558
22. Spencer TE, Bazer FW. Biology of progesterone action during pregnancy recognition and maintenance of pregnancy. Front Biosci 2002;7:d1879-d1898
23. Rider V. Progesterone and the control of uterine cell proliferation and differentiation. Front Biosci 2002;7:d1545-d1555
24. Baulieu EE. Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor. Science 1989;245:1351-1357
25. Baulieu EE. On the mechanism of action of RU 486. Ann NY Acad Sci 1991;626:545-560
26. Ding YQ, Zhu LZ, Bagchi MK, Bagchi IC. Progesterone stimulates calcitonin gene expression in the uterus during implantation. Endocrinology 1994;135:2265-2274
27. Cheon YP, Li Q, DeMayo FJ, Bagchi IC, Bagchi MK. A Genomic Approach to Identify Novel Progesterone Receptor Regulated Pathways in the Uterus during Implantation. Mol Endocrinol 2002;16:2853-2871
28. Das SK, Chakraborty I, Paria BC, Wang XN, Plowman G, Dey SK. Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol 1995;9:691-705
29. Ma L, Benson GV, Lim H, Dey SK, Maas RL. Abdominal B(AbdB) Hoxa genes: regulation in adults uterus by estrogen and progesterone and repression in Mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev Biol 1998;197:141-154
30. Muffly KE, Jin DF, Okulicz WC, Kilpatrick DL. Gonadal steroids regulate proenkephalin gene expression in a tissue-specific manner within the female reproductive system. Mol Endocrinol 1988;2:979-985
31. Paria BC, Das N, Das SK, Zhao X, Dileepan KN, Dey SK. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Endocrinology 1998;139:3958-3966
32. Martin L, Finn CA. Hormonal regulation of cell division in epithelial and connective tissues of mouse uterus. J Endocrinol 1968;41:363-371
33. Ducy P, Zhang R, Geoffroy V, Ridall AL, Kaesenty G. Osf2/ Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997;89:747-754
34. Enomoto H, Enomoto-Iwamoto M, Iwamoto M, et al. Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 2000;275:8695-8702
35. Luetteke NC, Qiu TH, Fenton SE, et al. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 1999;126:2739-2750
36. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999;20:189-206
37. Babic AM, Chen CC, Lau LF. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alpha v beta 3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 1999;19:2958-2966
38. Zhu L-J, Bove KC, Polihronis M, Bagchi MK, Bagchi IC. Calcitonin is a progesterone-regulated marker which forecasts the receptive state of endometrium during implantation. Endocrinology 1998;139:3923-3934
39. Rosen H, Itin A, Schiff R, Keshet E. Local regulation within the female reproductive system and upon embryonic implantation: identification of cells expressing proenkephalin A. Mol Endocrinol 1990;4:146-154
40. Manara L, Bianchetti A. The central and peripheral influences of opiods on gastrointestinal propulsion. Annu Rev Pharmacol Toxicol 1985;25:249-273
41. Henderson G, North RA. Depression by morphine of excitatory junction potentials in the vas deferens of the mouse. Br J Pharmacol 1976;57:341-346
42. Zhu LZ, Bagchi MK, Bagchi IC. Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation. Endocrinology 1998;139:330-339
43. Li Q, Wang J, Armant DR, Bagchi MK, Bagchi IC. Calcitonin Down-Regulates E-cadherin Expression in Uterine Epithelium during Implantation. J Biol Chem 2002;277:46447-46455
44. Li Q, Cheon YP, Kannan A, Shanker S, Bagchi IC, Bagchi MK. A novel pathway involving progesterone receptor, 12/15-lipoxygenease-derived eicosanoids, and peroxisome proliferator-activated receptor gamma? regulates implantation in mice. J Biol Chem 2004;2794:11570-11581
45. Mills JS, Needham M, Parker MG. A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas. EMBO J 1987;6:3711-3717
46. Chen LY, Lin YH, Lai ML, Chen YH. Developmental profile of a caltrin-like protease inhibitor, p12, in mouse seminal vesicle and characterization of its binding sites on sperm surface. Biol Reprod 1998;59:1498-1505
47. Delaria K, Fiorentino L, Wallace L, Tamburini P, Brownell E, Muller D. Inhibition of Cathepsin L-like Cysteine Proteases by Cytotoxic T-lymphocyte Antigen-2β. J Biol Chem 1994;269:25172-25177
48. Cheon YP, Demayo FJ, Bagchi MK, Bagchi IC. Induction of cytotoxic T-lymphocyte antigen-2 beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. J Biol Chem 2004;279:10357-10365
49. Cheon YP, Xu X, Bagchi MK, Bagchi IC. Immune-Responsive Gene 1 (Irg1) is a novel target of progesterone receptor and plays a critical role during implantation in the mouse. Endocrinology 2003;144:5623-5630
50. Chen B, Zhang D, Pollard JW. Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway. Mol Endocrinol 2003;17:2340-2354
51. Farnsworth RL, Talamantes F. Calcyclin in the mouse deciduas: expression and effects on placental lactogen secretion. Biol Reprod 1998;59:546-552
52. Meyer ME, Pornon A, Ji J, Bocquel MT, Chambon P, Gronemeyer H. Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J 1990;9:3923-3932
53. Sartorius CA, Tung L, Takimoto GS, Horwitz KB. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 1993;268:9262-9266
54. Beck CA, Weigel NA, Moyer ML, Nordeen SK, Edwards DP. The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways. Proc Natl Acad Sci USA 1993;90:4441-4445
55. Surveyor GA, Gendler SJ, Pemberton L, et al. Expression and steroid hormonal control of Mud in the mouse uterus. Endocrinology 1995;136:3639-3647
56. Teng CT, Pentiost BT, Chen YM, Newbold RR, Eddy EM, McLachlan JA. Lactoferrin gene expression in the mouse uterus and mammary gland. Endocrinology 1989;124:992-999
57. McMaster MT, Teng CT, Dey SK, Andrews GK. Lactoferrin in the mouse uterus: analysis of the preimplantation period and regulation by ovarian steroids. Mol Endocrinol 1992;6:101-111