Targets for antiageing drugs

Expert Opinion on Therapeutic Targets

Volumn 9, Issue 1, 2005, Pages 77-82

  Bergamini, Ettore ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Ageing; Antiagenic therapy; Antioxidants; Atherosclerosis; Autophagy; Cancer; Hypercholesterolaemia; Neurodegenerative disease; Proteasome

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; COPPER; DNA; DOLICHOL; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON CHELATING AGENT; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; PROTEASOME INHIBITOR; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; VITAMIN D; VITAMIN K GROUP; ZINC;

ANIMAL FOOD; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; AUTOPHAGY; CALORIC RESTRICTION; CANCER; CELL AGING; CELL MEMBRANE; CELL ORGANELLE; CELL REGENERATION; CELL RENEWAL; CELL STIMULATION; CELL SURVIVAL; DISEASE ASSOCIATION; DNA REPAIR; DRUG TARGETING; EXERCISE; HUMAN; LONGEVITY; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PREMATURE AGING; PROTEIN DEGRADATION; REVIEW;

AGING; ANIMALS; ANTIOXIDANTS; DRUG DELIVERY SYSTEMS; HUMANS; OXIDATIVE STRESS;

EID: 14744299290     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.9.1.77     Document Type: Review

References (55)

1. HOLLIDAY R: The close relationship between biological aging and age-associated pathologies in humans. J. Gerontol. Biol. Sci. (2004) 59A:543-546.
2. HAYFLICK L: The not-so-close relationship between biological aging and age-associated pathologies in humans. J. Gerontol. Biol. Sci. (2004) 59A:547-550.
3. MASORO EJ: Challenge of biological aging. Springer Publication Co. (1999).
4. WEINDRUCH R, SOHAL RJ: Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. (1997) 337:986-994.
5. SHOCK NW: The science of gerontology. In: Proceeding of Seminars 1959-1961. Jeffers EC, Durham NC (Eds), Council on Gerontology, Duke University Press (1962).
6. SHOMALI ME: The use of anti-aging hormones. Melatonin, growth hormone, testosterone, dehydroepiandrosterone: consumer enthusiasm for unproven therapies. Md. Med. J. (1997) 46:181-186.
7. BERGAMINI E, CAVALLINI G, DONATI A, GORI Z: The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int. J. Biochem. Cell Biol. (2004) 36 2392-2404.
8. PARENTINI I, CAVALLINI G, DONATI A, GORI Z, BERGAMINI E: The accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. J. Gerontol. Biol. Sci. (2004). In press.
9. VAN REMMEN H, IKENO Y, HAMILTON M et al.: Life-long reduction in MnSOD activity results in an increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics (2003) 16:29-37.
10. BERGAMINI E, BIZZARRI R, CAVALLINI G et al.: Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes? J. Alzheimer Dis. (2004) 6:129-135.
11. TAMBURINI I, QUARTACCI M, IZZO R, BERGAMINI E: Effects of caloric restriction on age-related changes in the phospholipid fatty acid composition of various rat tissues. Aging (2004). In press.
12. YOUDIM KA, DEANS SG: Beneficial effects of thyme oil on age-related changes in phospholipid C20 and C22 polyunsaturated fatty acid composition of various rat tissues. Biochim. Biophys. Acta (1999) 1438:140-146.
13. HASNIS E, REZNICK AZ: Antioxidants and healthy aging. Isr. Med. Ass. J. (2003) 5:368-370.
14. MEYDANI M: Nutrition interventions in aging and age-associated diseases. Ann. N Y Acad. Sci. (2001) 928 226-235.
15. YU BP, KANG CM, HAN JS, KIM DS: Can antioxidant supplementation slow the aging process? Biofactors (1998) 7:93-101.
16. WARD JA: Should antioxidant vitamins be routinely recommended for older people? Drugs Aging (1998) 12:169-175.
17. BERGAMINI E, CAVALLINI G, DONATI A, GORI G: The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed. Pharmacother. (2003) 57:203-208.
18. RAVIKUMAR B, VACHER C, BERGER Z et al.: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington's disease. Nat. Genet. (2004) 36:585-595.
19. INGRAM DK, ANSON RM, DE CABO R et al.: Development of calorie restriction mimeticsas a prolongevitystrategy. Ann. N Y Acad. Sci. (2004) 1019:412-423.
20. KARP G: In: Cell and Molecular Biology (3rd End). John Wiley & Sons, NY (2002):572-575.
21. MILLER RA: Gerontology as oncology. Research on aging as the key to the understanding of cancer. Cancer (1991) 68(11 Suppl.):2496-2501.
22. SOHAL RS, AGARWAL S, CANDAS M et al.: Effect of age and calorie restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech. Ageing Dev. (1994) 76:215-224.
23. TSAO JL, DUDLEY S, KWOK B et al.: Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis (2002) 23:1807-1810.
24. GEDIK CM, GRANT G, MORRICE PC et al.: Effects of age and dietary restriction on oxidative NA damage, antioxidant protection and DNA repair in rats. Eur. J. Nutr. (2004) Epub ahead of print.
25. CAMPANINI C, PETRONINI PG, ALFIERI R, BORGHETTI AF: Decreased expression of heat shock protein 70 A and protein in WI-38 human fibroblasts aging in vitro. Ann. N Y Acad. Sci. (1992) 663 442-443.
26. KELLER G, DIMAUGA E, CHEN Q ET AL.: Autophagy, proteasomes, lipofuscin and oxidative stress in the aging brain. Int. J. Biochem. Cell Biol. (2004) 36:2376-2391.
27. KWAK MK, WAKABAYASHI N, GREENLAW JL, YAMAMOTO M, KENSLER TW: Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell. Biol. (2003) 23 8786-8794.
28. ADAMS J, KAUFMANN M: Development of the proteasome inhibitor Velcade (Bortezomib) Cancer Invest. (2004) 22:304-311.
29. MCNAUGHT KS, PERL DP, BROWNELL AL, OLANOW CW: Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann. Neurol. (2004) 56:149-162.
30. CUERVO AM, DICE JF: Age-related decline in chaperone mediated autophagy. J. Biol. Chem. (2000) 275:31505-31513.
31. WANG CW, KLIONSKY DJ: The molecular mechanism of autophagy. Mol. Med. (2003) 9:65-76.
32. KANAZAWA T, TANEIKE I, AKAISHI R et al.: Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. J. Biol. Chem. (2004) 279:8452-8459.
33. SALMINEN A, VIHKO V: Autophagic response to strenuous exercise in mouse skeletal muscle fibers. Virchows Arch. B Cell. Biol. Ind. Mol. Pathol. (1984) 45:97-106.
34. SALAS M, TUCHWEBER B, KOUROUNAKIS P: Liver ultrastructure during acute stress. Pathol. Res. Pract. (1980) 167:217-233.
35. BERGAMINI E, DEL ROSO A, FIERABRACCI V et al.: A new method for the investigation of endocrine-regulated autophagy and protein degradation in rat liver. Exp. Mol. Pathol. (1993) 59:13-22.
36. DONATI A, CAVALLINI G, CARRESI C et al.: Antiaging effects of antilipolytic drugs. Exp. Gerontol. (2004) 39 1061-1067.
37. BLUEHER M, KAHN BB, KAHN CR: Extended longevity in mice lacking the insulin receptor in the adipose tissue. Science (2003) 299:572-574.
38. COUZIN J: Research on aging: gene links calorie deprivation and long life in rodents. Science (2004) 304:1731.
39. WEISBURGER JH: Antimutagens, anticarcinogens, and effective worldwide cancer prevention. J. Environ. Pathol. Toxicol. Oncol. (1999) 18:85-93.
40. DAVIDSON LA, NGUYEN DV, HOKANSON RM et al.: Chemopreventive n -3 Polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res. (2004) 64:6797-6803.
41. MARGOLIS S: The Johns Hopkins Medical Guide after 50. Rebus, NY (2002).
42. HURSTING SD, LAVIGNE JA, BERRIGAN D, PERKINS SN, BARRETT JC: Calorie restriction, aging, and cancer prevention: mechanisms of action andapplicability to humans. Ann. Rev. Med. (2003) 54:131-152.
43. GRUNE T, JUNG T, MERKER K, DAVIES KJ: Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int. J. Biochem. Cell Biol. (2004) 36:2519-2530.
44. ANDERSEN JK: Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. (2004) 10(Suppl.):S18-S25.
45. MITCHISON HM, LIM MJ, COOPER JD: Selectivity and types of cell death in the neuronal ceroid lipofuscinoses Brain. Pathol. (2004) 14:86-96.
46. HUANG X, MOIR RD, TANZI RE, BUSH AI, ROGERS JT: Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann. N Y Acad. Sci. (2004) 1012:153-163.
47. STEVENS A, LOWE J: Pathology (2nd Edn). Mosby, NY (2000).
48. PALLOTTINI V, MARINO M, CAVALLINI G, BERGAMINI E, TRENTALANCE A: Age-related changes of isoprenoid biosynthesis in rat liver and brain. Biogerontology (2003) 4:371-378.
49. PALLOTTINI V, PASCOLINI A, CAVALLINI G et al.: ROS influence on HMGCoA reductase: a study of the key enzyme of cholesterologenesis. Proceedings SIF Congress. Pisa, October (2004).
50. THOLSTRUP T, HELLGREN LI, PETERSEN M et al.: A solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in men. J. Nutr. (2004) 134 1051-1057.
51. BAVEELAR FJ, BEYNEN AC: Severity of atherosclerosis in parrots in relation to intake of alpha-linolenic acid. Avian Dis. (2003) 47:566-577.
52. HIRAFUJI M, MACHIDA T, HAMAUE N, MINAMI M: Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J. Pharmacol. Sci. (2003) 92 308-316.
53. KROMHOUT D, BOSSCHIETER EB, DE LEZENNE COULANDER C: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N. Engl. J. Med. (1985) 312 1205-1209.
54. MUNTEANU A, ZINGG JM, AZZI A: Anti-atherosclerotic effects of vitamin E - myth or reality? J. Cell Mol. Biol. (2004) 8 59-76.
55. NAPOLI C, WILLIAMS-IGNARRO S, DE NIGRIS F et al.: Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA (2004) 101:8797-8802.